Patient-identified burden and unmet needs in patients with cluster headache: An evidence-based qualitative literature review

Freeman, Emily; Adair, Michael; Beeler, Dori; Casper, Rozanne; Herman, Melissa P; Reeves, David; Reinsch, Stefan

doi:10.1177/25158163221096866

Cited by 2 publications

(1 citation statement)

References 72 publications

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“…Interestingly, neuromodulation studies of medically refractory CH failed to improve the quality of life, although the attack frequencies reduced. In a recent review by Freeman et al (23), significantly reduced quality of life was identified in a qualitative analysis of 11 studies conducted in the UK, Sweden, France, Korea, Germany, Denmark, Italy, Spain and Brazil. A significant impact on quality of life was also reported in Asian patients with CH, as reported in Korea (24) and China (25).…”

Section: Quality Of Lifementioning

confidence: 99%

Epidemiology, burden and clinical spectrum of cluster headache: a global update

Kim,

Choi,

Youn

et al. 2023

Cephalalgia

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Background This narrative review aims to broaden our understanding of the epidemiology, burden and clinical spectrum of cluster headache based on updated findings with a global perspective. Methods We conducted a literature search on the following topics: (a) epidemiology; (b) burden: quality of life, disability, economic burden, job-related burden and suicidality; and (c) clinical spectrum: male predominance and its changes, age, pre-cluster and pre-attack symptoms, aura, post-drome, attack characteristics (location, severity, duration and associated symptoms), bout characteristics (attack frequency, bout duration and bout frequency), circadian and seasonal rhythmicity and disease course. Results New large-scale population-based reports have suggested a lower prevalence than previous estimations. The impact of cluster headache creates a significant burden in terms of the quality of life, disability, economic and job-related burdens and suicidality. Several studies have reported decreasing male-to-female ratios and a wide age range at disease onset. The non-headache phases of cluster headache, including pre-cluster, pre-attack and postictal symptoms, have recently been revisited. The latest data regarding attack characteristics, bout characteristics, and circadian and seasonal rhythmicity from different countries have shown variability among bouts, attacks, individuals and ethnicities. Studies on the disease course of cluster headache have shown typical characteristics of attacks or bouts that decrease with time. Conclusions Cluster headache may be more than a “trigeminal autonomic headache” because it involves complex central nervous system phenomena. The spectrum of attacks and bouts is wider than previously recognised. Cluster headache is a dynamic disorder that evolves or regresses over time.

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Section: Quality Of Lifementioning

confidence: 99%