Patient knowledge and pulmonary medication adherence in adult patients with cystic fibrosis

Lin, Ann Hsu-An; Kendrick, Jennifer; Wilcox, Pearce; Quon, Bradley S.

doi:10.2147/ppa.s129088

Cited by 17 publications

(12 citation statements)

References 32 publications

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“…Knowledge about treatment has regularly been identified as a theme in qualitative studies (Sawicki et al ., ). However, consistent with studies showing no relationship between knowledge and adherence (Lin, Kendrick, Wilcox, & Quon, ; Modi & Quittner, ), this study shows that most participants report that they have good levels of knowledge. This is consistent with a systematic review that showed that knowledge is necessary but not sufficient to promote medication adherence (Kahwati et al ., ).…”

Section: Discussionsupporting

confidence: 90%

Adherence to medication in adults with Cystic Fibrosis: An investigation using objective adherence data and the Theoretical Domains Framework

Arden

Drabble

O’Cathain

et al. 2019

British J Health Psychol

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Objectives Adherence to nebulizer treatment in adults with Cystic Fibrosis ( CF ) is poor, and interventions are needed. This research aimed to identify the factors affecting nebulizer adherence using the Theoretical Domains Framework (TDF) and to compare these for participants with different levels of adherence. Design Data‐prompted interviews using the TDF. Methods Eighteen semi‐structured interviews were conducted with adults with CF during which objectively measured adherence data were discussed. Framework analysis was used to code the data into TDF domains, and inductive qualitative content analysis was used to code different beliefs and experiences. Aspects of the TDF that differed between participants with different adherence levels were explored. Results Factors influencing adherence to treatment included all 14 domains of the TDF , 10 of which appeared to vary by adherence level: Skills; Memory and decision‐making; and Behavioural regulation; Environmental context and resources; Social influences; Beliefs about consequences; Beliefs about capability; Reinforcement; Social role and identify; Intentions; Optimism; and Emotions. Conclusions This study is the first to use objectively measured adherence data in a data‐prompted interview using the TDF framework to systematically assess the full range of factors potentially influencing adherence. The results highlighted that interventions need to consider issues of capability, opportunity, and motivation. Interventions that challenge dysfunctional beliefs about adherence and which support the development of routines or habits and problem‐solving may be particularly useful for adults with CF . Statement of contribution What is already known? Adherence to medication in adults with cystic fibrosis is poor. Previous research has identified a range of contributing factors in relation to subjective reports of adherence. There is a wide discrepancy between self‐reported adherence and objectively measured adherence. What this study adds A data‐prompted interview using objectively measured adherence data enabled the systematic assessment of potential factors that could be targeted in an intervention to increase adherence. There were some differences in the factors that were identified by high and low adherers. There is not one‐size fits all intervention for adherence to medication in cystic fibrosis.

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Section: Discussionsupporting

confidence: 90%

Adherence to medication in adults with Cystic Fibrosis: An investigation using objective adherence data and the Theoretical Domains Framework

Arden

Drabble

O’Cathain

et al. 2019

British J Health Psychol

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“…The results showed that the differences of medication literacy in hypertensive patients with different levels of education were mainly manifested in the two dimensions of knowledge and skill literacy, which was similar to Newman et al [22]. However, Lin et al [23] found that knowledge related to disease was irrelevant to medication adherence. In the study, the knowledge and skill literacy of patients with education of high school or technical secondary school was significantly higher than that of patients with junior middle school or below.…”

Section: Education Level Influencing On Level Of Medication Literacy supporting

confidence: 71%

The status of medication literacy and associated factors of hypertensive patients in China: a cross-sectional study

Luo

Shen

et al. 2019

Intern Emerg Med

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The adverse consequence of low medication literacy is a major problem that threatens patients' health. The number of people with hypertension is increasing in China. We described the current situation of medication literacy of patients with hypertension in China and its related influencing factor. We conducted a cross-sectional study, which contains 590 hypertensive patients. Stratified sampling was adopted according to the hospital level in China. To determine the factors related to medication literacy, multiple linear regression analysis was used to determine associations between medication literacy of hypertensive patients and other factors. Among 590 respondents, results showed that they have poor medication literacy. Multiple linear regression analysis showed that level of education, annual income, occupation status, and type of medical insurance were significantly associated with medication literacy level of hypertensive patients. In addition, our study also demonstrates that we can identify the medication literacy level of hypertensive patients using the Chinese version Medication Literacy Scale for Hypertensive Patients. High medication literacy is an important factor for hypertensive patients to improve medication adherence, so as to better control blood pressure. We should pay attention to the improvement of medication literacy and take corresponding measures.

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“…Good tolerability of dornase alfa therapy, minimum treatment burden and time requirement play more important roles in medication adherence 44,45 . TOPIC 6.…”

Section: Statementmentioning

confidence: 99%

Use of dornase alfa in cystic fibrosis: an Audit of Italian specialists

Volpi

Carnovale

Colombo

et al. 2021

Preprint

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Background: The goal of mucoactive therapies in cystic fibrosis (CF) is to enhance sputum clearance and to reduce a progressive decline in lung function over the patient’s lifetime. We aimed to investigate the level of consensus among specialists from Italian CF Centers on appropriateness of therapeutic use of dornase alfa (rhDNase) for CF patients. Method: A consensus on appropriate prescribing in CF mucoactive agents was appraised by an online Delphi method, based on a panel of 27 pulmonologists, coordinated by a Scientific Committee of six experts in medical care of patients with CF. Results: Full or very high consensus was reached on several issues related to therapeutic use of dornase alfa for CF patients in clinical practice. Conclusions: Modified Delphi method was used to define the most appropriate use of dornase alfa in routine CF to improve lung function and long-term outcomes in patients, in agreement with international guidelines on CF management.

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Patient knowledge and pulmonary medication adherence in adult patients with cystic fibrosis

Cited by 17 publications

References 32 publications

Adherence to medication in adults with Cystic Fibrosis: An investigation using objective adherence data and the Theoretical Domains Framework

Adherence to medication in adults with Cystic Fibrosis: An investigation using objective adherence data and the Theoretical Domains Framework

The status of medication literacy and associated factors of hypertensive patients in China: a cross-sectional study

Use of dornase alfa in cystic fibrosis: an Audit of Italian specialists

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