Patient outcomes in schizophrenia II: the impact of cognition

Hofer, Alex; Baumgartner, Susanne E.; Bodner, Thomas; Edlinger, Monika; Hummer, Martina; Kemmler, Georg; Rettenbacher, Maria A.; Fleischhacker, W. Wolfgang

doi:10.1016/j.eurpsy.2005.02.006

Cited by 123 publications

(81 citation statements)

References 32 publications

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“…These results are not inconsistent with previous research that has found that more objective outcome measures such as employment status may be more valid measures of functional outcome than self-report measures (15). This may explain why in the current study employment status but not scores on the SFS were significantly associated with ARCS scores in the schizophrenia group.…”

Section: Discussioncontrasting

confidence: 66%

“…This may explain why in the current study employment status but not scores on the SFS were significantly associated with ARCS scores in the schizophrenia group. In addition, Hofer et al (15) proposed that the nature of work settings may make them particularly intolerant of impaired cognitive functioning. On the ARCS and functioning in schizophrenia other hand, an individual's subjective satisfaction with life may be relatively independent of cognitive functioning.…”

Section: Discussionmentioning

confidence: 99%

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Application of the Audio Recorded Cognitive Screen and its relation to functioning in schizophrenia

Gelder

Loughland

Carr

et al. 2015

Acta Neuropsychiatr.

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Gelder BM, Loughland CM, Carr VJ, Schofield PW. Application of the Audio Recorded Cognitive Screen and its relation to functioning in schizophrenia.Objective: This study investigated the ability of the Audio Recorded Cognitive Screen (ARCS) to detect cognitive deficit in individuals with schizophrenia, relative to the Mini Mental State Examination (MMSE) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and explored the associations between the ARCS and functional outcomes. We hypothesised that the ARCS would be able to better discriminate between individuals with schizophrenia and healthy controls than the MMSE, and that ARCS performance would be correlated with measures of social and vocational functioning. Methods: The participants were 19 community-dwelling individuals with schizophrenia or schizoaffective disorder and 19 healthy controls recruited from the Australian Schizophrenia Research Bank (ASRB). Participants completed the ARCS, MMSE, and self-report measures of social and vocational functioning. Clinical and diagnostic data stored by the ASRB were also utilised. Results: The schizophrenia group performed worse than the control group on the ARCS, with memory, t(36) = 2.49, p = 0.02, 95% CI [ − 1.84, −18.79] and fluency, t(36) = 2.40, p = 0.02, 95% CI [ − 1.87, −22.24] domains being the main discriminating measures. The RBANS also discriminated between the two groups, and ARCS and RBANS total scores were moderately to strongly correlated. There was no difference between the two groups on the MMSE after controlling for demographic variables. ARCS performance was associated with employment status [χ 2 (1) = 7.16, p = 0.007]. Conclusion: The ARCS may be sensitive to the cognitive deficits in outpatients with schizophrenia and an indicator of functional outcomes in this population. Significant outcomes• The Audio Recorded Cognitive Screen (ARCS) may be able to detect the cognitive deficits associated with schizophrenia. The memory and fluency domains are the main areas of discrimination.

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Section: Discussioncontrasting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Application of the Audio Recorded Cognitive Screen and its relation to functioning in schizophrenia

Gelder

Loughland

Carr

et al. 2015

Acta Neuropsychiatr.

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“…It is also possible that those with better insight may appreciate the impact of their mental illness on their QOL, leading to symptoms of depression. Previous research also indicates that the relationship between cognitive functioning and QOL may not be straightforward: Hofer et al (2005a) found no association, but Brekke and colleagues (2001) found that executive functioning moderated the relationship between psychosocial functioning and subjective QOL, such that patients with executive dysfunction showed a positive relationship between functioning and QOL, whereas intact patients showed a negative relationship between functioning and QOL. Furthermore, Bowie et al (in press) have found that schizophrenia patients with better cognitive abilities had more severe depressive symptoms and also overestimated their level of disability.…”

Section: Discussionmentioning

confidence: 99%

Subjective and objective quality of life in schizophrenia

Narvaez¹,

Twamley²,

McKibbin³

et al. 2008

Schizophrenia Research

227

139

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Objective-Quality of life (QOL) is considered an important outcome in the treatment of schizophrenia, but the determinants of QOL are poorly understood in this population. Furthermore, previous studies have relied on combined measures of subjective QOL (usually defined as life satisfaction) and objective QOL (usually defined as participation in activities and relationships). We examined separately the clinical, functional, and cognitive predictors of subjective and objective QOL in outpatients with schizophrenia. We hypothesized that better subjective QOL would be associated with less severe negative and depressive symptoms, better objective QOL, and greater everyday functioning capacity, and that better objective QOL would be associated with less severe negative and depressive symptoms, better cognitive performance, and greater functional capacity.Method-Participants included 88 outpatients with schizophrenia or schizoaffective disorder who completed a comprehensive series of assessments, including measures of positive, negative, and depressive symptoms; performance-based functional skills; a neuropsychological battery; and an interview measure of subjective and objective QOL.Results-In the context of multiple predictor variables, more severe depressive symptoms and better neuropsychological functioning were independent predictors of worse subjective QOL. More severe negative symptoms predicted worse objective QOL. Functional capacity variables were not associated with subjective or objective QOL.Conclusion-Treatments to improve QOL in schizophrenia should focus on negative symptoms and depressive symptoms.

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“…Working memory performance has recently been associated with functional outcome in a number of schizophrenia studies (Greenwood, Landau, & Wykes, 2005;Hofer et al, 2005;Revheim et al, 2006). This association has been strongest for patients with a preponderance of negative symptoms, and indeed negative symptoms have been found to correlate with performance deficits on measures of a variety of higher cognitive functions, including working memory (Donohoe et al, 2006a;Donohoe, Corvin, & Robertson, 2006;Donohoe & Robertson, 2003).…”

Section: Discussionmentioning

confidence: 99%

Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: A preliminary study

et al. 2007

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Susceptibility genes for schizophrenia have been hypothesised to mediate liability for the disorder at least partly by influencing cognitive performance. We investigated the association between genotype and cognitive performance for a Dysbindin risk haplotype which is associated with schizophrenia in our sample. Fifty-two patients with schizophrenia or schizoaffective disorder (24 risk haplotypes carriers versus 28 non-risk haplotype carriers) were assessed in areas of cognition showing evidence of familial deficits in schizophrenia. Verbal and spatial memory, working memory, and attentional control was assessed using selected measures from the Weschler memory scale (WMS), Cambridge automated test battery (CANTAB), continuous performance test (CPT), and a simple go/no-go task. Pre-morbid IQ was also assessed using the Weschler Test of Adult Reading (WTAR). Patients carrying the Dysbindin risk haplotype showed significantly lower spatial working memory performance than patients who were non-risk carriers, with genotype explaining 12% of variance in performance. Our study suggests that the increased risk for schizophrenia associated with dysbindin may be partly mediated by its influence on pre-frontal function.

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Patient outcomes in schizophrenia II: the impact of cognition

Abstract: These findings suggest that cognitive functioning is a key determinant of work functioning/independent living for stable outpatients with schizophrenia.

Cited by 123 publications

References 32 publications

Application of the Audio Recorded Cognitive Screen and its relation to functioning in schizophrenia

Application of the Audio Recorded Cognitive Screen and its relation to functioning in schizophrenia

Subjective and objective quality of life in schizophrenia

Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: A preliminary study

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