Patient Perceptions of and Preferences Between Characteristics of Injectable Diabetes Treatments

Boye, Kristina S.; Jordan, James O.; Malik, Raleigh E.; Currie, Brooke M.; Matza, Louis S.

doi:10.1007/s13300-021-01097-9

Cited by 12 publications

(19 citation statements)

References 57 publications

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“…39 Results of a survey of 504 people with type 2 diabetes in the United States or the United Kingdom identified confidence in administering the correct dose (59.5% of participants), ease of selecting the correct dose (53.2% of participants), overall ease of use (47.4% of participants), and frequency of injections (44.2% of participants) as the most important features that would determine their choice of an injection device (selected from 17 attributes). 43 These results confirmed previous reports indicating that receiving the correct insulin dose is the primary concern of individuals using insulin pen injectors 46,47 and that the likelihood of people using a device increases with their perception of its ease of use. 45,48,49…”

Section: Factors Affecting the Performance Of Insulin Pen Injector Te...supporting

confidence: 89%

Factors Affecting Performance of Insulin Pen Injector Technology: A Narrative Review

Sparre

Hammershøy

Steensgaard

et al. 2022

J Diabetes Sci Technol

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Background: Insulin treatment is an essential hormone replacement therapy for the survival of people with type 1 diabetes and is often used for treatment in type 2 diabetes, particularly as the disease progresses. Advances in insulin therapy have been made since its discovery, including production of human insulin and development of insulin analogs with improved efficacy and safety profiles. The different types of available insulin formulations allow health care professionals to personalize treatment to an individual’s needs. Generally, insulin requires parenteral administration via subcutaneous injection owing to very low oral bioavailability. Methods: This article reviews the human, technological, economical, and regulatory factors affecting the performance of insulin pens and the relationship between them. Opportunities and challenges that insulin pen injections may encounter in the future are also considered. Results: Insulin delivery devices, together with other factors, influence dose accuracy, convenience, and quality of life, contributing to easier medication administration with high efficacy and safety. For patients, ease of use, fast and accurate drug delivery, and painless injection are the most valuable features of an insulin injection device. For manufacturers, technological feasibility and economic viability also need to be considered when developing injection devices. Conclusion: Insulin pen injectors are generally preferred over vial and syringe, although access may be limited in some health care systems. Insulin pen injectors can adapt to different insulin regimens and formulations and have the potential to acquire dosing data in real time.

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Section: Factors Affecting the Performance Of Insulin Pen Injector Te...supporting

confidence: 89%

Factors Affecting Performance of Insulin Pen Injector Technology: A Narrative Review

Sparre

Hammershøy

Steensgaard

et al. 2022

J Diabetes Sci Technol

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“…The first insulin injections were made with large and heavy glass or metal syringes and reusable needles (4,7,(24)(25)(26). Syringe was the only possible way of delivering insulin in clinical practice for the next several decades (4,7,27).…”

Section: First-generation Insulin Pensmentioning

confidence: 99%

“…American and European guidelines underline the necessity of undertaking patient preference when selecting diabetes treatment especially when treatment is accoutered with pain due to injection ( 24 ). That is why recently a study assessing the patient perspective of injectable treatment among patients with type 2 diabetes (T2DM) has been performed and showed that there are some features of the injection device that patients choose more often which may help in future improvement of insulin pens ( 25 ). Development of insulin pens is parallel to the development of newer insulin formulation where insulin pen must adapt to changes to dosing and timing requirements like it is in case of modern ultra-long-acting insulin analogue icodec, administered once weekly, which is under development ( 26 ).…”

Section: Introductionmentioning

confidence: 99%

The Review of Insulin Pens—Past, Present, and Look to the Future

et al. 2022

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Currently, there are about 150–200 million diabetic patients treated with insulin globally. The year 2021 is special because the 100th anniversary of the insulin discovery is being celebrated. It is a good occasion to sum up the insulin pen technology invention and improvement which are nowadays the leading mode of an insulin delivery. Even though so many years have passed, insulin is still administered subcutaneously, that is why devices to deliver it are of great importance. Insulin pens have evolved only through the last decades (the reusable, durable pens, and the disposable, prefilled pens) and modern smart insulin pens have been developed in the last few years, and both types of the devices compared to traditional syringes and vials are more convenient, discrete in use, have better dosing accuracy, and improve adherence. In this review, we will focus on the history of insulin pens and their improvement over the previous decades.

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“…End users of all educational levels should be represented, and their involvement should continue throughout the development process, including the testing of early prototypes and new products with providers. Once products have reached the market, post-marketing surveillance and other types of user data, such as patients’ perceptions and preferences, 2 offer insights from their real-world use that can be used by developers to improve the next product versions or generations.…”

Section: Human-centered Design To Serve People Living With Diabetes: ...mentioning

confidence: 99%

Development of an Insulin Pen is a Patient-Centric Multidisciplinary Undertaking: A Commentary

Sparre

Hansen

Wernersson

et al. 2021

J Diabetes Sci Technol

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The goal of human-centered insulin pen design is to relieve the treatment burden of a chronic condition and help affected individuals to feel free of disease. The patient as well as their entire ecosystem should be considered. At Novo Nordisk A/S, we believe that embedding human-centered design at the heart of our development processes is best achieved with multidisciplinary experts in-house to work alongside product development teams and, importantly, the end user. Novo Nordisk introduced the first commercially available insulin pen in 1985 and has continued to develop reusable/durable and prefilled insulin pens to meet different patient needs, through to the latest NovoPen 6 and NovoPen Echo Plus with SMART technology. Human-centered design is essential for delivering meaningful and practical solutions for individuals with diabetes.

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Patient Perceptions of and Preferences Between Characteristics of Injectable Diabetes Treatments

Cited by 12 publications

References 57 publications

Factors Affecting Performance of Insulin Pen Injector Technology: A Narrative Review

Factors Affecting Performance of Insulin Pen Injector Technology: A Narrative Review

The Review of Insulin Pens—Past, Present, and Look to the Future

Development of an Insulin Pen is a Patient-Centric Multidisciplinary Undertaking: A Commentary

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