Patient–physician communication concerning participation in cancer chemotherapy trials

Sørensen, Jens Benn; Rossel, Peter; Holm, Søren

doi:10.1038/sj.bjc.6601524

Cited by 22 publications

(17 citation statements)

References 23 publications

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“…Finally, physicians should recognize that there may be differences between patients' and physicians' perception of the communication process and expectations of treatment benefit [53,72]. As a result, clinicians should clarify any differences in patient/provider trial expectations and be aware of patient satisfaction with the communication process.…”

Section: Ensuring That Clinicians Communicate Effectively With Their mentioning

confidence: 97%

Recommendations for Enhancing Clinical Trials Education: a Review of the Literature

et al. 2010

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This study aims to apply the evidence-based practice (EBP) process to determine the factors that influence patients' understanding of, participation in, and satisfaction with clinical trials, the informed consent process, and treatment decisions and to make recommendations for improving clinical trials education. Beginning with evidence retrieval, the authors identified key search terms and searched MEDLINE--Ovid, MEDLINE--PubMed, and the Cumulative Index to Nursing and Allied Health Literature to identify articles published between July 2001 and July 2006 that highlighted clinical trials education. The articles were reviewed for clinical trials patient education information, clinician methods of communicating clinical trial information to patients, and patient satisfaction with the clinical trials process, including the informed consent process. As a result, practice changes were recommended for the patient/family, staff/community, and institution. From the literature review, 81 articles were identified. Recurring themes included decision-making, patient education, staff education, and pediatrics. Most articles focused on methods and strategies aimed at improving education at the patient/family, staff/community, and institutional levels. The issues surrounding clinical trial education are complex due to multiple variables interfering with poor patient understanding of, participation in, and satisfaction with clinical trial treatment decisions. On the basis of our findings, we recommend that clinicians involved in educating patients, families, staff, and communities about clinical trials have an awareness of and understanding for very complex issues.

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Section: Ensuring That Clinicians Communicate Effectively With Their mentioning

confidence: 97%

Recommendations for Enhancing Clinical Trials Education: a Review of the Literature

et al. 2010

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“…This suggests that assuming that physicians would make the most 'realistic' or 'rational' choice, patients and caregivers seemed also make 'realistic' decisions with appropriate information. Although physicians often underestimated patients' ability to make decisions regarding trial participation, studies report that most patients entering Phase I trials feel that they were adequately informed about the purpose of the study, understood risks-benefits and had confidence making informed decisions (22).…”

Section: Discussionmentioning

confidence: 99%

“…Research suggests that people, including physicians, fail to construct their personal beliefs in accordance with probability theory (18). Given that most patients enrolled in trials understand the purposes correctly, the uncertainty of clinical outcomes, low likelihood of historical benefits (12,22), and expression of high expectations were interpreted as therapeutic optimism rather than therapeutic misconception or misestimation (5,12,23,24). Patients and physicians facing inevitable death might know that the chance of having benefits is low but still maintain hope that their own chance of getting therapeutic benefits is high (24,25).…”

Section: Discussionmentioning

confidence: 99%

Attitudes toward participating in Phase I clinical trials: an investigation with patient–family–physician triads

Shin

Cho

Kim

et al. 2016

Japanese Journal of Clinical Oncology

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Objective: Phase I oncology trials have raised concerns that patients' 'unrealistic' optimism could compromise the validity of informed consent, and that patients often participate in trials to conform to physicians' or family members' recommendations. We aimed to determine whether patients or families-given the same information of risk-benefit profile-are more likely to participate in Phase I trials than their physicians and whether people in family or physician situations are more likely to recommend trial participation to patients than they would want for themselves as patients. Methods: We conducted a hypothetical vignette study with a patient-caregiver-oncologist. Three groups-725 patient-caregiver pairs recruited by 134 oncologists-were asked to assume three different roles as patients, caregivers and physicians and provided a scenario of a hypothetical patient with treatment-resistant cancer. They were asked questions regarding their intention to participate in or to recommend a Phase I clinical trial. Results: Acceptance rates of the trial were as follows: (a) in the patients' role: patients (54.1), caregivers (62.3) and physicians (63.4%); (b) in the caregivers' role: 55.6, 64.7 and 70.9%; (c) in the physicians' role: 66.1, 70.8 and 76.1%. Patients or caregivers were not more positive to the trial than physicians. All three groups showed more positive attitudes toward the clinical trial when they assumed the role of caregiver or physician than that of patient. Conclusions: Patients and caregivers seem to make as reasonable decisions as physicians; patients seem to take family members' or physicians' recommendation as their legitimate roles rather than as undue pressure.

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“…[66] However, there is little evidence that clinicians can solicit, or reliably predict their patient’s preferred level of participation. [67–69] Not only is their wide variability in patients’ decision participation preferences, but physicians tend to define patient decision participation more as agreement rather than engagement . [70–72] In sum, this work has shown, that patients expect understandable information provided in an open and supportive way.…”

Section: Introductionmentioning

confidence: 99%

Modeling patient-centered communication: Oncologist relational communication and patient communication involvement in breast cancer adjuvant therapy decision-making

Step

Rose

Albert

et al. 2009

Patient Education and Counseling

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Objective-Relational communication refers to those messages communicators naturally express that carry meaning about the type and quality of relationship they share. It is expected that patients of oncologists who express positive relational communication will be more communicatively involved in their office visits, and regret their decision for adjuvant therapy following surgery less. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Methods-One Conflict of interestThe authors state no actual or potential conflict of interest, including financial, personal or organizational, within three years of beginning the submitted work, that could inappropriately influence, or be perceived to influence, their work. NIH Public Access

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Patient–physician communication concerning participation in cancer chemotherapy trials

Cited by 22 publications

References 23 publications

Recommendations for Enhancing Clinical Trials Education: a Review of the Literature

Recommendations for Enhancing Clinical Trials Education: a Review of the Literature

Attitudes toward participating in Phase I clinical trials: an investigation with patient–family–physician triads

Modeling patient-centered communication: Oncologist relational communication and patient communication involvement in breast cancer adjuvant therapy decision-making

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