Chronic Obstructive Pulmonary Disease (COPD) is a chronic illness that requires regular treatment to relieve symptoms and reduce the frequency of relapses and the severity of exacerbations. Treatment options for COPD are pharmacological and non-pharmacological therapies, and patients can prefer the type of treatment. The inhaler is one of the options for pharmacological therapy, where there are several types of inhalers, including metered dose inhalers (MDI), soft mist inhalers (SMI) and dry powder inhalers (DPI). To date, there is no synthesis on the patient's preference of treatment for COPD. The review aimed to synthesize available evidence on patients' preferences for COPD treatment. Three databases, which include PubMed, Ebsco, and Scopus, were searched using terms related to "Patient Preference", "Preference Treatment", "Chronic Obstruction Pulmonary Disease", and "Chronic Airway Obstruction Disease". From the three databases, 2,757 articles were obtained and screened from a title with EndNote to remove duplication. The author and the team discuss the abstract and the full text to decide whether it meets the inclusion criteria. A total of 10 articles were included. We found patients prefer dry powder inhalers, spray inhalers, and relaxation by imagining a beautiful place as an option. The results of the literature review show that there are several preferences for COPD therapy; DPI inhalers are preferred because they are easy to use and have a low error rate.