Most
breast implants currently used in both reconstructive and
cosmetic surgery have a silicone outer shell, which, despite much
progress, remains susceptible to mechanical failure, infection, and
foreign body response. This study shows that the durability and biocompatibility
of breast implant-grade silicone can be enhanced by incorporating
carbon nanomaterials of sp2 and sp3 hybridization
into the polymer matrix and onto its surface. Plasma treatment of
the implant surface can be used to modify platelet adhesion and activation
to prevent thrombosis, postoperative infection, and inflammation disorders.
The addition of 0.8% graphene flakes resulted in an increase in mechanical
strength by 64% and rupture strength by around 77% when compared to
pure silicone, whereas when nanodiamond (ND) was used as the additive,
the mechanical strength was increased by 19.4% and rupture strength
by 37.5%. Composites with a partially embedded surface layer of either
graphene or ND showed superior antimicrobial activity and biocompatibility
compared to pure silicone. All composite materials were able to sustain
the attachment and growth of human dermal fibroblast, with the preferred
growth noted on ND-coated surfaces when compared to graphene-coated
surfaces. Exposure of these materials to hydrogen plasma for 5, 10,
and 20 s led to substantially reduced platelet attachment on the surfaces.
Hydrogen-treated pure silicone showed a decrease in platelet attachment
for samples treated for 5–20 s, whereas silicone composite
showed an almost threefold decrease in platelet attachment for the
same plasma treatment times. The absence of platelet activation on
the surface of composite materials suggests a significant improvement
in hemocompatibility of the material.