BackgroundUnderstanding the influence of contextual factors (CFs) on interventions for mechanical neck pain (MNP) is essential for evidence‐based practice in physical therapy. However, the specific effects and synergies of combining different CFs remain unclear.ObjectiveThe primary purpose of this study will be to determine if a CFs‐Enriched Standard Care (SC) approach is an effective treatment for MNP in terms of reducing pain and improving function.MethodsThis will be an assessor‐blinded, 2‐group (1:1) randomised clinical trial (RCT) aiming to enrol 94 participants with neck pain persisting for more than 4 weeks. Both groups will undergo 4 weeks of SC twice weekly, following established clinical practice guidelines. In the intervention group, CFs will be enhanced, encompassing the physical, psychological, and social elements inherent in the clinical encounter, based on existing evidence. The primary outcomes will encompass changes in pain and disability after 4 weeks of treatment, with a follow‐up reassessment at week 12 post‐treatment. Secondary outcomes will include changes in Active Range of Motion, Global Rating of Change, and Satisfaction with treatment. The change between groups after treatment and at the 12‐week follow‐up will be reported for all outcomes, considering the difference from scores recorded at baseline.ResultsWe hypothesise that a 4‐week CFs‐Enriched SC approach will be superior to SC alone in terms of patient‐reported disability and pain, with measurements conducted using the Northwick Park Neck Pain Questionnaire and the Numeric Pain Rating Scale, respectively.ConclusionThis RCT rigorously assesses the effect of purposeful manipulation of CFs during MNP treatment. By elucidating the role of these factors, our findings have the potential to significantly refine clinical practice in managing MNP, thereby enhancing patient care, and advancing the fields of physical therapy and rehabilitation.