Patient‐reported outcomes as assessment tools and predictors of long‐term prognosis: a 7‐year follow‐up study of patients with rheumatoid arthritis

Kojima, Masayo; Kojima, Toshihisa; Suzuki, Sadao; Takahashi, N.; Funahashi, Koji; Asai, Shuji; Yoshioka, Yutaka; Terabe, Kenya; Asai, Nobuyuki; Takemoto, Takahiro; Ishiguro, Naoki

doi:10.1111/1756-185x.12789

Cited by 20 publications

(19 citation statements)

References 38 publications

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“…Thus, evaluating the disease from patients’ perspectives by using patient-reported outcomes [PROs] to assess pain, functional capacity, and fatigue etc . are essential in investigating the burden of RA [11, 12]. The impact of RA on patients and society is acknowledged in Japan [13] and there is growing awareness of HRQoL for RA patients.…”

Section: Introductionmentioning

confidence: 99%

“…Monitoring PROs in routine medical care could guide treatment choices for health care professionals when there is a discrepancy between patient and physicians’ assessment [12-17, 18]. Despite the increasing importance of patients’ HRQoL, currently there is no specific Japan guidance on how to measure HRQoL or what aspect of HRQoL to measure in the routine clinical setting.…”

Section: Introductionmentioning

confidence: 99%

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The Use of patient Reported Outcome Measures for Rheumatoid Arthritis in Japan: A Systematic Literature Review

Tang¹,

Kim

Crawford

et al. 2017

TORJ

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Background:Patient-reported outcomes (PRO) obtained through routine medical care may identify patients’ day-to-day burden and help tackle the disease from the patients’ perspective. However, there is a paucity of information regarding the availability of PRO data and PRO tools for rheumatoid arthritis (RA) in Japan.Objective: We reviewed the literature on PRO data availability and to identify PRO measures implemented in Japan for RA patients. Method: We conducted a systematic literature review using ICHUSHI and the PubMed databases on PRO measures for RA published from January 2011 to August 2015 in Japan.Results:After removing duplicates, 2423 manuscripts were found. From these, 100 manuscripts were included for review and analysis. We found 29 PRO tools that were used to assess various domains of health such as general well-being, pain, functionality, and fatigue. More than 90% of the studies utilized PRO tools for research purpose. Only one study reported PRO tool implementation in the routine medical care.Conclusion:The importance of PROs is recognized in Japan. PRO tools varied significantly and were mostly used for research purposes, while reports on the use of PRO measures in routine medical care were limited. Despite the awareness of PROs in the research community, unmet needs remain among RA patients in Japan. Further work is needed to investigate ways in which PROs can better reflect these unmet needs and be utilized in routine medical care.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Use of patient Reported Outcome Measures for Rheumatoid Arthritis in Japan: A Systematic Literature Review

Tang¹,

Kim

Crawford

et al. 2017

TORJ

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“…In combination, MTX with biological disease-modifying antirheumatic drugs (bDMARDs), has contributed to an increased amount of patients who have achieved clinical remission. As a result of this increase in the rate of clinical remission, the number of patients achieving structural and functional remission has also increased (2)(3)(4)(5). Complete remission in a patient is defined as the achievement of clinical, functional, and structural remission (6).…”

Section: Introductionmentioning

confidence: 99%

A study on characteristics of rheumatoid arthritis patients achieving remission in depression with 6 months of bDMARDs treatment

et al. 2018

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Objective: To investigate the relationship between baseline factors and depression remission after a 6-month biological disease-modifying antirheumatic drugs (bDMARDs) treatment in rheumatoid arthritis (RA) patients. Methods: The study was conducted in 152 RA patients treated with bDMARDs. The following patient's characteristics were studied: gender, age, disease duration, baseline prednisolone dosage, and serum matrix metalloproteinase3 (MMP3) levels. For assessment, we used the simple disease activity index (SDAI) for RA disease activity, Health Assessment Questionnaire Disability Index (HAQ-DI) for activities of daily living (ADL), Short Form-36 for nonspecific health-related quality of life (QOL), and Hamilton Depression Rating Scale (HAM-D) scores for the depression status. Depressed remission was clarified using HAM-D ≤7 after 6 months of treatment. The patients were divided into two groups according to the presence or absence of depression, and a retrospective study was conducted. Results: Based on binominal logistic analyses, RA patients' with depression remission (n=124) compared to those without depression remission (n=28) had a younger age (p=0.0045, odd ratio: 0.94, 95% confidence interval [CI]:0.8-0.98), female sex (p=0.021, odd ratio:0.21, 95% CI:0.054-0.79), and lower HAM-D scores (p=0.0073, odd ratio:0.85, 95% CI:0.76-0.96) Conclusion: It was proposed that RA patients who are females, younger in age, and have lower depressed scores at baseline can achieve a depression remission status with the bDMARDs treatment.

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“…In the field of rheumatoid arthritis (RA), the validity and effectiveness of PRO data in addition to the standard clinical practice for the intensive care of the patients is well documented [7,8]. A recent systematic review from Johns Hopkins University assesses the frequency and the analyzed domains of PRO used in recent RA studies by collecting and summarizing data from 250 articles [9].…”

Section: Introductionmentioning

confidence: 99%

Pixel or Paper? Validation of a Mobile Technology for Collecting Patient-Reported Outcomes in Rheumatoid Arthritis

Epis¹,

Casu²,

Belloli³

et al. 2016

JMIR Res Protoc

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BackgroundIn the management of chronic disease, new models for telemonitoring of patients combined with the choice of electronic patient-reported outcomes (ePRO) are being encouraged, with a clear improvement of both patients’ and parents’ quality of life. An Italian study demonstrated that ePRO were welcome in patients with rheumatoid arthritis (RA), with excellent matching data.ObjectiveThe aim of this study is to evaluate the level of agreement between electronic and paper-and-pencil questionnaire responses.MethodsThis is an observational prospective study. Patients were randomly assigned to first complete the questionnaire by paper and pencil and then by tablet or in the opposite order. The questionnaire consisted of 3 independent self-assessment visual rating scales (Visual Analog Scale, Global Health score, Patient Global Assessment of Disease Activity) commonly used in different adult patients, including those with rheumatic diseases.ResultsA total of 185 consecutive RA patients were admitted to hospital and were enrolled and completed the questionnaire both on paper and on electronic versions. For all the evaluated items, the intrarater degree of agreement between 2 approaches was found to be excellent (intraclass correlation coefficient>0.75, P<.001).ConclusionsAn electronic questionnaire is uploaded in a dedicated Web-based tool that could implement a telemonitoring system aimed at improving the follow-up of RA patients. High intrarater reliability between paper and electronic methods of data collection encourage the use of a new digital app with consequent benefit for the overall health care system.

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Patient‐reported outcomes as assessment tools and predictors of long‐term prognosis: a 7‐year follow‐up study of patients with rheumatoid arthritis

Abstract: Remission criteria including PROMs are stringent but important to achieve sustained remission. Early intensive treatment and efforts to improve patients' health perceptions may result in better prognosis for RA.

Cited by 20 publications

References 38 publications

The Use of patient Reported Outcome Measures for Rheumatoid Arthritis in Japan: A Systematic Literature Review

The Use of patient Reported Outcome Measures for Rheumatoid Arthritis in Japan: A Systematic Literature Review

A study on characteristics of rheumatoid arthritis patients achieving remission in depression with 6 months of bDMARDs treatment

Pixel or Paper? Validation of a Mobile Technology for Collecting Patient-Reported Outcomes in Rheumatoid Arthritis

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