Patient-Reported Outcomes Following Total Thyroidectomy for Graves' Disease

Gunn, Alexander; Frisco, Nicholas A.; Thomas, Samantha M.; Stang, Michael T.; Scheri, Randall P.; Kazaure, Hadiza S.

doi:10.1089/thy.2021.0285

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…Traditionally, surgical outcomes were considered the most important when gauging the success of surgery; however, the paradigm has evolved to recognize the significance of patient-reported outcomes as metrics of surgical success 54 . Measurement of patient-reported outcomes is important for surgeons to appreciate the subjective implications of surgery on a patient’s quality of life 55 , such as basic activities of daily living like showering. Interestingly, it is well reported that patients should be able to shower safely 24 h after neck surgery (and that showering does not increase wound infections) 56 , 57 , yet this study highlights apprehension among patients regarding showering, particularly after stapled closures.…”

Section: Discussionmentioning

confidence: 99%

Optimal primary wound closure methods after thyroid and parathyroid surgery: network meta-analysis of randomized clinical trials

et al. 2023

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Background At present, there is no consensus on optimal neck wound closure methods after thyroid and parathyroid surgery. The aim of this study was to perform a systematic review and network meta-analysis of RCTs evaluating the optimal neck closure method after thyroid and parathyroid surgery. Methods A frequentist random-effects network meta-analysis was performed for RCTs comparing at least two closure methods according to PRISMA-network meta-analysis guidelines. Analysis was performed using R packages and Shiny. Results Eighteen RCTs evaluating six closure methods (that is adhesive (28.5 per cent, 404 patients), absorbable subcuticular suture (18.1 per cent, 257 patients), non-absorbable subcuticular suture (16.8 per cent, 238 patients), staples (26.3 per cent, 372 patients), steristrips (8.1 per cent, 115 patients), and conventional suture (2.1 per cent, 30 patients)) in 1416 patients were included. At network meta-analysis, there was no difference in complication, infection, dehiscence, or haematoma rates irrespective of closure method used. Staples reduced closure duration versus absorbable subcuticular suture (mean difference (MD) 8.50, 95 per cent c.i. 6.90 to 10.10) and non-absorbable subcuticular suture (MD 0.30, 95 per cent c.i. 0.23 to 0.37), whereas adhesives (MD −1.05, 95 per cent c.i. −1.31 to −0.79) reduced closure time relative to staples. Cosmesis was improved after non-absorbable subcuticular suture (odds ratio (OR) 3.41, 95 per cent c.i. 1.66 to 7.00) relative to staples. Staples reduced patient satisfaction (OR 0.04, 95 per cent c.i. 0.00 to 0.33) and ability to shower (OR 0.04, 95 per cent c.i. 0.00 to 0.33) relative to adhesives. Conclusion Despite staples decreasing closure times, this advantage is offset by reduced patient satisfaction, ability to shower, and cosmesis compared with patients with wounds closed using adhesives, absorbable subcuticular suture, and non-absorbable subcuticular suture. Therefore, these closure methods are favourable for closing neck wounds due to more acceptable patient-reported outcomes, without compromising the safety of the procedure.

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Section: Discussionmentioning

confidence: 99%

Optimal primary wound closure methods after thyroid and parathyroid surgery: network meta-analysis of randomized clinical trials

et al. 2023

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“…Graves' disease (GD) is a chronic autoimmune thyroid disease associated with multiple body systems [ 1 ]. It is the most common cause of hyperthyroidism, accounting for ~80% of all cases of hyperthyroidism and affecting approximately 1% of the general population [ 2 , 3 ]. People can be affected at any age, and females have a higher morbidity rate [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of lncRNA Expression Profile and the Potential Role of ENST00000604491 in Graves’ Disease

Liu

Zou

et al. 2022

Journal of Immunology Research

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Background. Graves’ disease (GD) is one of the most common autoimmune diseases worldwide and develops in 20 to 50 cases per 100,000 persons annually. Long noncoding RNAs (lncRNAs) are widely expressed in multiple human diseases and have pivotal functions in gene regulation. This study is aimed at determining the lncRNA profile in peripheral blood mononuclear cells (PBMCs) from GD patients and investigating the role of ENST00000604491 in GD. Methods. A total of 31 GD patients and 32 normal controls were enrolled in the study. Next-generation sequencing was performed to identify the dysregulated lncRNAs in the PBMCs from the 5 GD patients and 5 normal controls, and 26 GD patients and 27 controls were used to verify the selected lncRNAs. The relative expression of verified lncRNAs, forkhead box P1 (FOXP1), and IKAROS family zinc finger 3 (IKZF3) from these samples was detected by quantitative real-time PCR. The potential biomarker value was assessed by using receiver operating characteristic (ROC) curve analysis. Results. A total of 37,683 dysregulated expressed lncRNAs were indicated, of which 5 lncRNAs were significantly upregulated and 83 lncRNAs were remarkably downregulated in the GD patients compared with healthy subjects. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses showed that abnormally expressed lncRNAs were mainly enriched in immune system-related signalling pathways. Among the selected lncRNAs, the relative expression of ENST00000604491 was significantly downregulated and negatively correlated with the serum levels of thyroid-stimulating hormone receptor antibodies (TRAb) in GD patients. Further studies confirmed that decreased FOXP1 expression was inversely correlated with serum TRAb levels in GD patients. Moreover, there was a notably positive correlation between ENST00000604491 expression and FOXP1 transcript levels in GD. The area under the ROC curve of ENST00000604491 was up to 0.74 (95% confidence interval: 0.60-0.87, p < 0.01 ), and the sensitivity and specificity were 53.85% and 88.89%, respectively. Conclusion. The present study identifies ENST00000604491 as a significantly attenuated lncRNA in GD patients, which may contribute to the pathogenesis of GD by regulating FOXP1 and represent a potential biomarker for GD.

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“…About 80% of all cases of hyperthyroidism are due to Graves' disease [4]. The prevalence of thyrotoxicosis in Russia in 2001 was 18.4 cases per 100,000 people [1].…”

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confidence: 99%

Clinical Significance of Antibodies to Thyrotropic Hormone Receptor as a Biomarker of Graves Disease Activity

Tsurkan¹,

Lushchik²,

Makeeva³

2022

EJNH

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Objective: to study the clinical significance of antibodies to thyroid-stimulating hormone receptors as a biomarker of Graves' disease activity in patients in the Voronezh region. A retrospective study of 76 patients with Graves' disease treated at Voronezh Regional Clinical Hospital #1 from 2018 to 2021 was carried out. Qualitative and quantitative indicators were assessed: anamnestic data, features of the clinical picture, the results of laboratory and instrumental research methods at the first visit, in 6 and 12 months after antithyroid therapy. During the study, 3 groups were formed: group 1 -patients with Graves' disease -35 people, group 2 -patients with Graves' disease in combination with previously untreated endocrine ophthalmopathy -41 people, group 3 -control group of 15 people without thyroid disease. Our study found that male gender, smoking, free triiodothyronine levels, the severity of thyrotoxicosis and the presence of endocrine ophthalmopathy had a positive correlation with high levels of antibodies to thyroid-stimulating hormone receptors. Measurement of the level of antibodies to thyroid-stimulating hormone receptors in the blood in patients with Graves' disease helps to assess the course of Graves' disease complicated by endocrine ophthalmopathy and allows to determine the risk of activity and severity of endocrine ophthalmopathy. Determining the level of antibodies to thyroid-stimulating hormone receptors is recommended not only for rapid diagnosis, differential diagnosis, but also for monitoring the adequacy of treatment of patients with Graves' disease.

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Patient-Reported Outcomes Following Total Thyroidectomy for Graves' Disease

Cited by 5 publications

References 27 publications

Optimal primary wound closure methods after thyroid and parathyroid surgery: network meta-analysis of randomized clinical trials

Optimal primary wound closure methods after thyroid and parathyroid surgery: network meta-analysis of randomized clinical trials

Comprehensive Analysis of lncRNA Expression Profile and the Potential Role of ENST00000604491 in Graves’ Disease

Clinical Significance of Antibodies to Thyrotropic Hormone Receptor as a Biomarker of Graves Disease Activity

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