Patient‐reported outcomes with calcipotriol/betamethasone aerosol foam in patients with plaque psoriasis in Greece. Results from the CELSUS study

Abstract

further emphasized the importance of elimination diets for GC. 7 A cinnamon-and benzoate-free diet with allergen avoidance for 3 months and 2 years improved lip oedema and orofacial oedema, respectively. Given a growing body of evidence suggesting a link between food allergens and GC, clinicians are increasingly open to incorporating dietary modifications in their clinical practice. 8-10 However, there remain practical challenges associated with elimination diet compliance, in part, due to the difficulties in recognizing which foods contain allergens such as benzoate. 8 While we recognize the practical challenges that come with dietary avoidance of allergens, we express optimism that cinnamon-and benzoate-free diets can be particularly efficacious as adjunct therapy. We agree with Kreuter et al. about the difficulty of treating granulomatous cheilitis, but we believe diet modification and allergen avoidance can enhance response to therapy.

Calcipotriol/betamethasone aerosol foam (Enstilum) for the topical treatment of psoriasis vulgaris in routine practice in Korea: A prospective, noninterventional, multicenter study of treatment outcomes and patient satisfaction

“…Real-world evidence is becoming increasingly important, and observational studies of patients treated with Cal/BD foam in routine practice have been conducted in several Western countries (Germany, the US, Italy, Spain, and Greece). [10][11][12][13][14] However, there are limited data on outcomes in Asian patients treated with Cal/BD foam.…”

Sub‐population analysis of patients with plaque psoriasis treated with calcipotriol/betamethasone aerosol foam; effectiveness and patient satisfaction, according to baseline disease severity and prior psoriasis treatment experience, in a Greek population

“…[22][23][24] Effectiveness and treatment satisfaction with Cal/BD aerosol foam were also observed in the whole population of the CELSUS study. 17,18 In this post-hoc analysis, when patients were stratified by previous treatment experience and disease severity, Cal/BD aerosol foam was found to be effective and was associated with high levels of patient satisfaction. This is supported by the study of Gerdes et al…”

“…Following the initial publication of the primary results of the study, 17,18 the present post-hoc analysis sought to further investigate the baseline characteristics and the changes of clinical and patientreported outcomes by the baseline severity of psoriasis and by treatment experience for patients who were treated with Cal/BD aerosol foam in the real world setting. The results included patients' baseline demographics and clinical characteristics, history of prior treatments for psoriasis and satisfaction with these, and reasons for choosing Cal/BD aerosol foam.…”

“…Effectiveness results were associated with a clinically significant reduction in itch, improved quality of life, and patient satisfaction with the treatment. 17,18 Here, we present results of a post-hoc analysis of the CELSUS study, aiming primarily to provide additional real-world data on Cal/BD aerosol foam in psoriasis by assessing the effectiveness and treatment satisfaction in population subgroups stratified according to treatment experience and severity of psoriasis at baseline.…”

“…The real‐world CELSUS study of Cal/BD aerosol foam to treat psoriasis in Greece demonstrated substantial effectiveness, based on the proportion of patients achieving treatment success at the end of week 4 (physician's global assessment [PGA] scores of 0 [clear] or 1 [almost clear]) and the reduction of the mean psoriasis‐affected BSA from baseline to week 4 (coprimary objectives). Effectiveness results were associated with a clinically significant reduction in itch, improved quality of life, and patient satisfaction with the treatment 17,18 …”