Patient-Reported Quality of Life 3 Months after Breast Reconstruction

Avino, Adelaida; Gheoca-Mutu, Daniela Elena; Raducu, Laura; Nedelea, S.; Jecan, Cristian Radu; Lascar, Ioan

doi:10.21614/chirurgia.116.2.232

Cited by 3 publications

(1 citation statement)

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“…Además de las expectativas de la paciente. (6) La calidad de vida y los buenos resultados estéticos tras el tratamiento del cáncer de mama son fundamentales. La cirugía reconstructiva está diseñada para mejorar la calidad de vida al proporcionar mejoras físicas y psicológicas y medidas de mitigación para ayudar a las mujeres a superar las barreras anatómicas, socioeconómicas y emocionales y restaurar sus vidas a la normalidad.…”

Section: Introductionunclassified

Methods in breast reconstruction for patients with a history of breast cancer after total or partial mastectomy care

Crespo

Zeas

Cueva

2023

Salud, Ciencia y Tecnología

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Breast cancer is an oncologic process in which healthy cells of the mammary gland degenerate and transform into tumor cells, proliferating and multiplying until the tumor is formed. It is known that breast cancer is one of the main causes of death in women. Therefore, mastectomy is one of the most used medical interventions to prevent, fight or stop breast cancer totally or partially. Due to this, the aim of this work was to determine the method or methods used for breast reconstruction for patients with a history of breast cancer after a total or partial mastectomy, and also to know a little about possible complications if any, to know which would be the most assertive to apply to the patient, for which information was collected in databases, and using a method similar to PRISMA a necessary number of articles that met the criteria for the preparation of the work were chosen, and search terms were used in pages such as MESH/DECS. Among the main methods found to achieve breast reconstruction was the immediate reconstruction that can even be applied at the time of mastectomy, however, the technique to be used will depend on the patient’s case, as soft tissue flaps can be used, as well as autologous tissues that are cataloged with better results even than radiotherapy.

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Section: Introductionunclassified

Methods in breast reconstruction for patients with a history of breast cancer after total or partial mastectomy care

Crespo

Zeas

Cueva

2023

Salud, Ciencia y Tecnología

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The Satisfaction and Quality of Life of Patients After Breast Reconstruction

Alghamdi,

Alhefdhi,

Fayi

et al. 2024

Ann Plast Surg

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Background Breast reconstruction following mastectomy can be performed through various surgical techniques that prioritize the patient's safety and quality of life. Plastic surgeons are trained to choose the most appropriate surgical approach based on the individual patient's needs and medical history. The safety of the patient is always the primary concern, followed by considerations such as aesthetic outcomes and long-term health implications. Objectives The aim of this study was to assess and document patients' satisfaction and quality of life after breast reconstruction across Saudi Arabia. Methods This is a cross-sectional multicenter study among female patients who underwent mastectomy with or without breast reconstruction between 2015 and 2022. Two hundred eighty patients participated in this study through a call-based Arabic version of the BREAST-Q questionnaire to analyze the quality of their lives and satisfaction. Results Our results showed that patients who underwent delayed reconstruction had lower satisfaction than those who underwent immediate reconstruction. The average BREAST-Q score was lower in patients who used tissue expanders than those with implant-based reconstruction, autologous reconstruction, or combined approaches. Patients who underwent simple mastectomy had lower satisfaction (M = 66.1) than those who had a skin-sparing mastectomy (M = 71.1) and/or nipple-sparing mastectomy (M = 72.6). Conclusions This retrospective multicenter study observed a significant association between the time of the reconstructive surgery and patient's satisfaction; patients who underwent immediate reconstruction had higher satisfaction rate. Lower satisfaction rate was associated with tissue expander breast reconstruction. There is a significant association between satisfaction rate and smoking history.

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Immune subtype identification and multi-layer perceptron classifier construction for breast cancer

et al. 2022

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IntroductionBreast cancer is a heterogeneous tumor. Tumor microenvironment (TME) has an important effect on the proliferation, metastasis, treatment, and prognosis of breast cancer.MethodsIn this study, we calculated the relative proportion of tumor infiltrating immune cells (TIICs) in the breast cancer TME, and used the consensus clustering algorithm to cluster the breast cancer subtypes. We also developed a multi-layer perceptron (MLP) classifier based on a deep learning framework to detect breast cancer subtypes, which 70% of the breast cancer research cohort was used for the model training and 30% for validation.ResultsBy performing the K-means clustering algorithm, the research cohort was clustered into two subtypes. The Kaplan-Meier survival estimate analysis showed significant differences in the overall survival (OS) between the two identified subtypes. Estimating the difference in the relative proportion of TIICs showed that the two subtypes had significant differences in multiple immune cells, such as CD8, CD4, and regulatory T cells. Further, the expression level of immune checkpoint molecules (PDL1, CTLA4, LAG3, TIGIT, CD27, IDO1, ICOS) and tumor mutational burden (TMB) also showed significant differences between the two subtypes, indicating the clinical value of the two subtypes. Finally, we identified a 38-gene signature and developed a multilayer perceptron (MLP) classifier that combined multi-gene signature to identify breast cancer subtypes. The results showed that the classifier had an accuracy rate of 93.56% and can be robustly used for the breast cancer subtype diagnosis.ConclusionIdentification of breast cancer subtypes based on the immune signature in the tumor microenvironment can assist clinicians to effectively and accurately assess the progression of breast cancer and formulate different treatment strategies for different subtypes.

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Patient-Reported Quality of Life 3 Months after Breast Reconstruction

Cited by 3 publications

References 0 publications

Methods in breast reconstruction for patients with a history of breast cancer after total or partial mastectomy care

Methods in breast reconstruction for patients with a history of breast cancer after total or partial mastectomy care

The Satisfaction and Quality of Life of Patients After Breast Reconstruction

Immune subtype identification and multi-layer perceptron classifier construction for breast cancer

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