Patient's perspectives of living with a precancerous condition: Monoclonal gammopathy of undetermined significance (MGUS)

Murphy, Blain; McShane, Charlene M.; Santin, Olinda; Treanor, Charlene; Byrne, Bronagh; Donnelly, Michael; Anderson, Lesley A.

doi:10.1016/j.ejon.2021.101901

Cited by 10 publications

(9 citation statements)

References 41 publications

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“…[ 3 , 78 , 79 ] In-depth evidence on the mental health effects of cancer screening can help advocate for interventions, as research suggests that social and healthcare professional support can reduce anxiety levels. [ 44 , 45 ] Specifically, carefully designed RCTs are needed to fully evaluate when screening is justifiable to complete a half-painted picture. RCTs can be strengthened by integrating validated mental health measures at baseline and longitudinally across groups.…”

Section: Discussionmentioning

confidence: 99%

“…The participants also reported feelings of isolation, increased uncertainty, and limited psychosocial support. [44] In summary, the mental health effects of receiving positive results of having a cancer precursor or risk factor seem more severe than those of less intensive screening. However, in general, negative effects seem most prominent in the days and weeks after the results and typically subside over time.…”

Section: Mental Health Effects Of Diagnostic Risk Factormentioning

confidence: 99%

“…The participants also reported feelings of isolation, increased uncertainty, and limited psychosocial support. [ 44 ]…”

Section: Evidence On the Mental Health Effects Of Cancer Screeningmentioning

confidence: 99%

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The half-painted picture: Reviewing the mental health impacts of cancer screening

et al. 2022

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Cancer screening is recommended for select cancers worldwide. Cancer screening has become increasingly effective and accessible and often increases overall survival. However, the mental health effects of cancer screening, such as its impact on depression, anxiety, and post-traumatic stress disorder, are largely unknown. Conflicting available literature indicates the negative, neutral, and positive mental health effects of cancer screening across cancer types. There are a limited number of randomized controlled trials measuring the mental health effects of cancer screening. Overall, the more negative and life-threatening the screening results, the greater the mental health effects. Screening for cancer without a known precursor, for example, due to family history, can have positive impacts such as decreased worry and increased quality of life. However, receiving a cancer diagnosis often has negative mental effects that increase with the life-threatening potential of malignancy. In this study, we review the existing literature and provide recommendations for future research to determine if and when cancer screening is the best practice.

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Section: Discussionmentioning

confidence: 99%

Section: Mental Health Effects Of Diagnostic Risk Factormentioning

confidence: 99%

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The half-painted picture: Reviewing the mental health impacts of cancer screening

et al. 2022

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“…These observations are similar to a qualitative study of patients with MGUS in Ireland, which found that an MGUS diagnosis can result in isolation and increased uncertainty. 14 This study had several strengths including the evaluation of both patient and providers' perspectives of MGUS, but it also has limitations. First, we recruited a relatively small number of patients, and the use of ResearchMatch and/or social media for recruitment may limit the generalizability of the results, as our participants may be more educated or engaged than typical patients.…”

Section: Discussionmentioning

confidence: 99%

“…13 A recent qualitative study from Ireland described the stress that patients with MGUS endured during diagnosis and follow-up appointments due to uncertainty about potential progression to multiple myeloma. 14 Patients also reported experiencing isolation, poor information-provision and increased uncertainty after MGUS diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Patient and providers-level drivers of healthcare utilization related to a diagnosis of a precancerous condition: monoclonal gammopathy of undetermined significance (MGUS)

Castañeda‐Avila

Mazor

Lapane

et al. 2022

Preprint

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Purpose Monoclonal gammopathy of undetermined significance (MGUS) is the precursor of multiple myeloma. This qualitative study described patient (n = 14) experiences and healthcare providers’ (n = 8) opinions and practices concerning care for patients with MGUS in the US. Methods Semi-structured, in-depth interviews were analyzed using thematic analysis. Results We identified six overarching themes related to the care pathway for patients with MGUS. (1) Process of MGUS diagnosis, (2) Providers’ explanations, (3) Patients’ understanding, (4) Impact of the diagnosis, (6) follow-up/management, and (6) factors influencing healthcare utilization. Patients demonstrated a basic understanding of MGUS. However, some patients felt anxiety around the diagnosis, which may affect other aspects of their lives. Non-hematologist providers report having less MGUS-specific knowledge. Older age, high-risk MGUS, and insurance/cost influenced healthcare utilization. Conclusion Patients with MGUS may have difficulty processing this premalignant diagnosis. Non-hematologist providers may have gaps in knowledge around specific care for patients with MGUS.

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Patient and provider-level drivers of healthcare utilization related to a diagnosis of a precancerous condition: monoclonal gammopathy of undetermined significance (MGUS)

Castañeda‐Avila

Mazor

Lapane

et al. 2023

Cancer Causes Control

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Patient's perspectives of living with a precancerous condition: Monoclonal gammopathy of undetermined significance (MGUS)

Cited by 10 publications

References 41 publications

The half-painted picture: Reviewing the mental health impacts of cancer screening

The half-painted picture: Reviewing the mental health impacts of cancer screening

Patient and providers-level drivers of healthcare utilization related to a diagnosis of a precancerous condition: monoclonal gammopathy of undetermined significance (MGUS)

Patient and provider-level drivers of healthcare utilization related to a diagnosis of a precancerous condition: monoclonal gammopathy of undetermined significance (MGUS)

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