The hospital is the optimal setting for conducting research on healthcare quality improvement and patient safety, and hospital medicine is an auspicious field for career growth. Integrating clinical practice with non-clinical activities, including education and scholarly endeavors, has the potential to enhance job satisfaction and mitigate the risk of burnout. As a hospitalist, it is imperative to establish a professional growth plan, and to identify and prioritize core values. This review discusses strategies for engaging in research, fostering career progression, and preventing burnout among hospitalists.