Patient satisfaction and efficacy of switching from weekly bisphosphonates to monthly minodronate for treatment and prevention of glucocorticoid-induced osteoporosis in Japanese patients with systemic rheumatic diseases: a randomized, clinical trial

Tamechika, Shinya; Sasaki, Kaneshige; Hayami, Yoshihito; Ohmura, Shin-Ichiro; Maeda, Shinji; Iwagaitsu, Shiho; Naniwa, Taio

doi:10.1007/s11657-018-0451-7

Cited by 9 publications

(16 citation statements)

References 37 publications

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“…The majority of patients were female, and eight studies included solely females [ 22 , 25 – 28 , 30 , 32 ]. Seven studies were European [ 22 , 26 , 27 , 30 – 33 ], five studies North-American [ 24 , 25 , 29 , 34 , 35 ], two from Australia [ 21 , 28 ], and one from Japan [ 23 ]. Follow-up time varied from 6 to 24 months [ 21 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…Other interventions were conducted by trained coordinators ( n = 1) [ 35 ], medical secretaries ( n = 1) [ 22 ], pharmacists ( n = 1) [ 33 ], or a combination of physicians and allied healthcare workers ( n = 1) [ 36 ]. Four studies did not report by whom the intervention was conducted [ 23 , 25 , 30 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

“…Adherence was reported as initiation ( n = 1), implementation ( n = 9), and discontinuation ( n = 4). In two studies, the type of adherence was not described [ 23 , 24 ]. Initiation was described as initiation of osteoporosis treatment by primary care physician 12 months after a fragility fracture [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…Three studies evaluated the effect of alterations in drug regimen compared with usual care. Of these studies, two were RCTs and one was an observational study [ 23 , 32 , 33 ]. Adherence (not further defined) was the primary outcome in one study [ 23 ], while the two other studies focused on both implementation and discontinuation [ 32 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…Of these studies, two were RCTs and one was an observational study [ 23 , 32 , 33 ]. Adherence (not further defined) was the primary outcome in one study [ 23 ], while the two other studies focused on both implementation and discontinuation [ 32 , 33 ]. The studies concerned single-component interventions as either offering patients a choice of flexible dosing regimen [ 32 ] or switching to an alternative drug with longer dosing intervals [ 23 ], or multicomponent interventions of a combination of signaling of non-adherence, and offering alternative medication combined with counseling [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

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Interventions to improve adherence to anti-osteoporosis medications: an updated systematic review

et al. 2020

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Summary An earlier systematic review on interventions to improve adherence and persistence was updated. Fifteen studies investigating the effectiveness of patient education, drug regimen, monitoring and supervision, and interdisciplinary collaboration as a single or multi-component intervention were appraised. Multicomponent interventions with active patient involvement were more effective. Introduction This study was conducted to update a systematic literature review on interventions to improve adherence to anti-osteoporosis medications. Methods A systematic literature review was carried out in Medline (using PubMed), Embase (using Ovid), Cochrane Library, Current Controlled Trials, ClinicalTrials.gov , NHS Centre for Review and Dissemination, CINHAL, and PsycINFO to search for original studies that assessed interventions to improve adherence (comprising initiation, implementation, and discontinuation) and persistence to anti-osteoporosis medications among patients with osteoporosis, published between July 2012 and December 2018. Quality of included studies was assessed. Results Of 585 studies initially identified, 15 studies fulfilled the inclusion criteria of which 12 were randomized controlled trials. Interventions were classified as (1) patient education ( n = 9), (2) drug regimen ( n = 3), (3) monitoring and supervision ( n = 2), and (4) interdisciplinary collaboration ( n = 1). In most subtypes of interventions, mixed results on adherence (and persistence) were found. Multicomponent interventions based on patient education and counseling were the most effective interventions when aiming to increase adherence and/or persistence to osteoporosis medications. Conclusion This updated review suggests that patient education, monitoring and supervision, change in drug regimen, and interdisciplinary collaboration have mixed results on medication adherence and persistence, with more positive effects for multicomponent interventions with active patient involvement. Compared with the previous review, a shift towards more patient involvement, counseling and shared decision-making, was seen, suggesting that individualized solutions, based on collaboration between the patient and the healthcare provider, are needed to improve adherence and persistence to osteoporosis medications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Interventions to improve adherence to anti-osteoporosis medications: an updated systematic review

et al. 2020

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Utility of monthly minodronate for osteoporosis after gastrectomy: Prospective multicenter randomized controlled trials

Hirota

Takahashi

Saito

et al. 2021

Annals of Gastroent Surgery

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Supporting patients to get the best from their osteoporosis treatment: a rapid realist review of what works, for whom, and in what circumstance

Paskins

Babatunde²,

Sturrock³

et al. 2022

Osteoporos Int

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Systematic reviews that examine effectiveness of interventions to improve medicines optimisation do not explain how or why they work. This realist review identified that interventions which effectively optimise medicines use in osteoporosis include opportunities to address patients' perceptions of illness and treatment and/or support primary care clinician decision making. Introduction In people with osteoporosis, adherence to medicines is poorer than other diseases and patients report followup is lacking, and multiple unmet information needs. We conducted a rapid realist review to understand what contextual conditions and mechanisms enable interventions to support osteoporosis medication optimisation. Methods A primary search identified observational or interventional studies which aimed to improve medicines adherence or optimisation; a supplementary second search identified research of any design to gain additional insights on emerging findings. Extracted data was interrogated for patterns of context-mechanism-outcome configurations, further discussed in team meetings, informed by background literature and the Practicalities and Perception Approach as an underpinning conceptual framework. Results We identified 5 contextual timepoints for the person with osteoporosis (identifying a problem; starting medicine; continuing medicine) and the practitioner and healthcare system (making a diagnosis and giving a treatment recommendation; reviewing medicine). Interventions which support patient-informed decision making appear to influence long-term commitment to treatment. Supporting patients' practical ability to adhere (e.g. by lowering treatment burden and issuing reminders) only appears to be helpful, when combined with other approaches to address patient beliefs and concerns. However, few studies explicitly addressed patients' perceptions of illness and treatment. Supporting primary care clinician decision making and integration of primary and secondary care services also appears to be important, in improving rates of treatment initiation and adherence. Conclusions We identified a need for further research to identify a sustainable, integrated, patient-centred, and cost-and clinically effective model of long-term care for people with osteoporosis.

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Patient satisfaction and efficacy of switching from weekly bisphosphonates to monthly minodronate for treatment and prevention of glucocorticoid-induced osteoporosis in Japanese patients with systemic rheumatic diseases: a randomized, clinical trial

Abstract: Monthly minodronate is more acceptable and may be more effective than weekly alendronate or risedronate for prevention and treatment of bone loss in patients with systemic rheumatic diseases on glucocorticoid therapy.

Cited by 9 publications

References 37 publications

Interventions to improve adherence to anti-osteoporosis medications: an updated systematic review

Interventions to improve adherence to anti-osteoporosis medications: an updated systematic review

Utility of monthly minodronate for osteoporosis after gastrectomy: Prospective multicenter randomized controlled trials

Supporting patients to get the best from their osteoporosis treatment: a rapid realist review of what works, for whom, and in what circumstance

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