Patient selection for heart transplant: balancing risk

Mantha, Aditya; Lee, Ramon O.; Wolfson, A.M.

doi:10.1097/mot.0000000000000943

Cited by 8 publications

(4 citation statements)

References 69 publications

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“…Heart failure (HF) stands as a preeminent global health issue [1] , wherein Congestive Heart Failure (CHF) represents its most incapacitating manifestation, distinguished by the heart's incapacity to effectively circulate blood to sustain a life of well-being [2] . While heart transplantation remains the quintessential therapeutic approach for advancedstage CHF, its feasibility is confined by the dearth of suitable donors and potential contraindications [3] . Left Ventricular Assist Devices (LVADs) proffer an alternative remedy, serving as both a bridge to heart transplantation (BTT) and a modality of destination therapy (DT) for those ineligibles for transplantation [4] .…”

Section: Introductionmentioning

confidence: 99%

Intelligent embedded system for physiological control of ventricular assist devices in health 4.0 Background

Santos,

Barboza,

Leão

et al. 2023

IJAMB

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The use of Left Ventricular Assist Devices (LVADs) has proven to be an effective treatment option for Congestive Heart Failure (CHF) patients who are not eligible for heart transplantation. These devices can serve as a bridge to heart transplantation (BTT) or as destination therapy (DT). While LVADs operate at a constant flow, this can affect the patient's quality of life and survival rate. To address this issue, Health 4.0 (H4) has developed new technological resources to personalize control systems and integrate medical devices into treatment. In this effort, a Physiological Control of LVAD (PC-LVAD) system was implemented within the H4 platform, using an Intelligent Embedded System (IES). The IES was developed using the MyRIO® development platform and tools such as LabVIEW® FPGA and RT, Quartus II® EDA, and MATLAB®. To evaluate its performance, preliminary criteria were assessed in experimental tests, analyzing the Internet of Things (IoT) characterization and applying best practices for information security. The results of the experimental tests showed that the IES could store and transmitting data in real-time to a graphical interface, and the data were found to be consistent with external measuring instruments.

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Section: Introductionmentioning

confidence: 99%

Intelligent embedded system for physiological control of ventricular assist devices in health 4.0 Background

Santos,

Barboza,

Leão

et al. 2023

IJAMB

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“…B. Lunge, Leber etc. ), Virushepatitis, Sepsis mit positiver Blutkultur, Meningitis, Drogen- oder Alkoholabhängigkeit oder generell fehlende Adhärenz der zu transplantierenden Person sein 12 13 .…”

Section: Indikation Und Kontraindikationunclassified

Der lange Weg in ein Leben mit einem neuen Herz

Mannebach¹,

Rakowski²,

Brakhage³

et al. 2023

intensiv

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“…Heart failure (HF) stands as the most significant global health concern, with congestive heart failure (CHF) representing the most debilitating stage, characterized by the heart's incapacity to pump enough blood to sustain a healthy life [1]. While heart transplantation remains the gold standard for treating end-stage CHF, the limited number of available donors and potential contraindications constrain its effectiveness [2].…”

Section: Introductionmentioning

confidence: 99%

Embedded Cyber-physical System for Physiological Control of Ventricular Assist Devices

Santos,

Leao,

Barboza

et al. 2024

Preprint

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Left Ventricular Assist Devices (LVADs) serve as both a bridge to transplantation and a destination therapy for managing congestive heart failure (CHF). However, the existing control strategy's inability to automatically adapt to hemodynamic changes can significantly impact patient survival rates and quality of life. Researchers have proposed various approaches to achieve Physiological Control over LVADs (PC-LVAD). Despite promising results, implementing these strategies on computers faces limitations due to substantial differences in controller characteristics between computers and embedded systems. An embedded cyber-physical system (CPS) was proposed to address this challenge, integrating real-time data processing, reconfigurable architecture, and communication protocols based on Health 4.0 concepts. To evaluate this embedded CPS, a multi-objective PC-LVAD was utilized in a hybrid cardiovascular simulator with an implanted LVAD, testing symmetry between the original proposal of the PC-LVAD and the version running on the embedded CPS. The embedded CPS demonstrated comparable results to the control executed on a computer, maintaining mean arterial pressure and cardiac output at physiological levels, even amid variations in ejection fraction. Furthermore, the pump's rotational speed was dynamically adjusted based on simulated clinical conditions, and no aortic reflux to the ventricle occurred through the LVAD during testing. These outcomes affirm the embedded CPS's satisfactory control performance. However, additional testing is imperative to validate its enhanced physiological strategies in embedded CPS during in vivo experiments.

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Patient selection for heart transplant: balancing risk

Cited by 8 publications

References 69 publications

Intelligent embedded system for physiological control of ventricular assist devices in health 4.0 Background

Intelligent embedded system for physiological control of ventricular assist devices in health 4.0 Background

Der lange Weg in ein Leben mit einem neuen Herz

Embedded Cyber-physical System for Physiological Control of Ventricular Assist Devices

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