Patient-specific Analysis of Periodontal and Peri-implant Microbiomes

Dabdoub, Shareef M; Tsigarida, Alexandra; Kumar, Purnima

doi:10.1177/0022034513504950

Cited by 172 publications

(216 citation statements)

References 28 publications

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“…interdental space, emerging evidence suggests that they could be microbiologically distinct from each other (Kumar et al 2012;Dabdoub et al 2013;Heuer et al 2012). By use of broad-range PCR techniques (Heuer et al 2012) and pyrosequencing (Kumar et al 2012;Dabdoub et al 2013) it was demonstrated that the peri-implant microbiome was distinct from the periodontal microbiome. Given the distinct topography and immunological characteristics of the implant compared to the tooth, the two ecosystems could be regarded divergent.…”

Section: Distinct Peri-implant Microfloramentioning

confidence: 99%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

108

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Biofilms are complex microbial communities that grow on various surfaces in nature. The oral micobiota tend to form polymicrobial biofilms, particularly on the hard mineralized surfaces of teeth, which may impact on oral health and disease. They can cause inflammation of the adjacent tooth-supporting (periodontal) tissues, leading to destructive periodontal disease and tooth loss. The emergence of osseointegrated dental implants as a restorative treatment option for replacing missing teeth has also brought along new artificial surfaces within the oral cavity, on which oral bacteria can form biofilms. As in the case of natural teeth, biofilms on implant surfaces may also trigger infection and cause inflammatory destruction of the peri-implant tissue (i.e. peri-implantitis). While there are strong similarities in the composition of the mixed microbial flora between periodontal and peri-implant infections, there are also a few distinctive differences. The immunological events underlying the pathogenesis of peri-implant infections are qualitatively similar, yet more extensive, compared to periodontal infections, resulting in a faster progression of tissue destruction. This chapter summarizes the current knowledge on the microbiology and immunology of peri-implant infections, including findings from the peri-implant crevicular fluid, the inflammatory exudate of the peri-implant tissue. Moreover, it discusses the diagnosis and current approaches for the treatment of oral infections.

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Section: Distinct Peri-implant Microfloramentioning

confidence: 99%

Peri-Implant Infections of Oral Biofilm Etiology

Belibasakis

Charalampakis

Bostancı

et al. 2014

Advances in Experimental Medicine and Biology

108

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“…However, several recent studies reported that the microbial composition of biofilm was more complex in peri-implant disease than in periodontal disease. The prevalence of periodontopathic bacteria is not high in peri-implantitis (26,27,46,47). Future studies may help to clarify these findings.…”

Section: Discussionmentioning

confidence: 92%

Prevalence and risk factors for peri-implant diseases in Japanese adult dental patients

et al. 2017

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We investigated the prevalences and risk factors for peri-implant diseases in Japanese adult dental patients attending a follow-up visit at dental hospitals or clinics as part of their maintenance program. This cross-sectional multicenter study enrolled patients with dental implants who attended regular check-ups as part of a periodontal maintenance program during the period from October 2012 through September 2013. Patients with implants with at least 3 years of loading time were included in the study. The condition of peri-implant tissue was examined and classified into the following categories: healthy, peri-implant mucositis, and peri-implantitis. Patients were also evaluated for implant risk factors. A total of 267 patients (110 men, 157 women; mean age: 62.5 ± 10.7 years) were analyzed. The prevalence of patient-based peri-implant mucositis was 33.3% (n = 89), and the prevalence of peri-implantitis was 9.7% (n = 26). Poor oral hygiene and a history of periodontitis were strong risk factors for peri-implant disease. The present prevalences were lower than those previously reported. The quality of periodontal therapy before and after implant installation and patient compliance and motivation, as indicated by plaque control level, appear to be important in maintaining peri-implant tissue health.

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“…Therefore, with regards to oral environment, Candida can participate not only in the pathogenesis of oral candidiasis [1], but also in endodontic, periodontal and peri-implant infections [26]. Clinically, it is suggested that eugenol could be used as an adjuvant substance to the control of C. albicans infection, especially in endodontic infection, as a component of zinc oxide pastes [27].…”

Section: Discussionmentioning

confidence: 99%

Antifungal Activity of Eugenol and its Association with Nystatin on Candida albicans

Silva

Santos

Cavalcanti

et al. 2017

Pesqui. bras. odontopediatria clín. integr.

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Objective: To evaluate the anti-Candida effect of eugenol and its antimicrobial interaction with nystatin. Material and Methods: The antimicrobial potential was assessed by microdilution technique (M27A3 reference method), by determining the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) against C. albicans (ATCC 90028). The possible action of eugenol on the fungal cell wall was evaluated with the assistance of the osmotic protector sorbitol (0.8 M). The antimicrobial interaction with nystatin was assessed through the checkerboard method. All tests were performed in triplicate. Results: All groups showed reductions in PI and GBI values and improvements in oral health knowledge, but IG1 and IG2 showed statistically significant differences in these variables compared to CG. Conclusion: The eugenol has antifungal activity against C. albicans and its mechanism of action is probably not related to damage to the fungal cell wall. Association between eugenol and nystatin was not found to be an advantageous possibility for growth inhibition of C. albican.

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Patient-specific Analysis of Periodontal and Peri-implant Microbiomes

Cited by 172 publications

References 28 publications

Peri-Implant Infections of Oral Biofilm Etiology

Peri-Implant Infections of Oral Biofilm Etiology

Prevalence and risk factors for peri-implant diseases in Japanese adult dental patients

Antifungal Activity of Eugenol and its Association with Nystatin on Candida albicans

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