Patient-specific computational fluid dynamic simulation of a bilateral bidirectional Glenn connection

Sun, Qiang; Wan, Dawei; Liu, Jinfen; Hong, Haifa; Liu, Yingzheng; Zhu, Ming

doi:10.1007/s11517-008-0376-1

Cited by 12 publications

(7 citation statements)

References 19 publications

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“…[36][37][38] Actually, material wall properties need the definition of a suitable description of the constitutive behavior, which strictly depends on patient features. [39][40][41] Glenn models are composed of veins and arteries with very different material wall properties, which are presently difficult to infer from clinical data.…”

Section: Discussionmentioning

confidence: 99%

Numerical Study of Bidirectional Glenn With Unilateral Pulmonary Artery Stenosis

Zhao

Liu

Ding

et al. 2014

J. Mech. Med. Biol.

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Purpose: Hypoplastic left heart syndrome (HLHS) is a congenital heart disease and is usually associated with pulmonary artery stenosis. The superior vena cava-to-pulmonary artery (bidirectional Glenn) shunt is used primarily as a staging procedure to the total cava-topulmonary connection for single-ventricle complex. When HLHS coexists with pulmonary artery stenosis, the surgeons then face a multiple problem. This leads to high demand of optimized structure of Glenn surgery. The objective of this article is to investigate the influence of various anastomotic structures and the direction of superior vena cava (SVC) in Glenn on hemodynamics under pulse inflow conditions and try to find an optimal structure of SVC in Glenn surgery with unilateral pulmonary artery stenosis.Method: First, 3D patient-specific models were constructed from medical images of a HLHS patient before any surgery by using the commercial software Mimics, and another software Free-form was used to deform the reconstructed models in the computer. Four 3D patient-specific Glenn models were constructed: model-1 (normal Glenn), model-2 (lean the SVC back to the stenotic pulmonary artery), model-3 (lean the SVC towards the stenotic pulmonary artery), model-4 (add patch at junction of the SVC toward stenosis at pulmonary artery). Second, a lumped parameter model (LPM) was established to predict boundary conditions for computational fluid dynamics (CFD). In addition, numerical simulations were conducted using CFD through the finite volume method. Finally, hemodynamic parameters were obtained and evaluated.Results: It was showed that model-4 have relatively balanced vena cava blood perfusion into the left pulmonary artery (LPA) and right pulmonary artery (RPA), this may be due to ‡ Corresponding author. . Downloaded from www.worldscientific.com by MONASH UNIVERSITY on 02/04/15. For personal use only.less helical flow and the patch at junction of the SVC. Near stenosis of pulmonary artery, model-4 performed with the higher wall shear stress (WSS), which would benefit endothelial cell function and gene expression. In addition, results showed that model-4 performed with the lower oscillatory shear index (OSI) and wall shear stress gradient (WSSG), which would decrease the opportunity of vascular intimal hyperplasia.Conclusion: It is benefited that surgeons adds patch at junction of the SVC towards stenosis at pulmonary artery. These results can impact the surgical design and planning of the Glenn surgery with unilateral pulmonary artery stenosis.

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Section: Discussionmentioning

confidence: 99%

Numerical Study of Bidirectional Glenn With Unilateral Pulmonary Artery Stenosis

Zhao

Liu

Ding

et al. 2014

J. Mech. Med. Biol.

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“…Although this approach has been applied to Glenn, Fontan procedure, as well as CoA surgery, the link between altered indices and different types of aortic deformation is still elusive. 9,10 The objective of this work is to quantify the hemodynamic changes with different vascular structures of post-operation CoA, which contributes to further understanding of the pathologic effect for abnormal hemodynamics and identifying patients that need further treatment in the follow-up.…”

Section: For Reprints Contact: Weda-h@weda-horgmentioning

confidence: 99%

Comparison of hemodynamics in post-operation coarctation of aorta patients with different aortic arch geometry

Ridderbos¹,

Qiao²,

Shen³

et al. 2019

JAH

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Individual aortic baroreceptors are sensitive to different ranges of blood pressures SCIENCE CHINA Life Sciences 57, 502 (2014); Seismic damage-cracking analysis of arch dams using different earthquake input mechanisms Science in China Series E-Technological Sciences 52, 518 (2009); High level HIV-1 DNA concentrations in brain tissues differentiate patients with post-HAART AIDS dementia complex or cardiovascular disease from those with AIDS Science in China Series C-Life Sciences 52, 651 (2009); Operation of silicon-germanium heterojunction bipolar transistors with different structures at deep cryogenic temperature Science Bulletin 64, 469 (2019);

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“…Earlier studies reconstructed simplified geometries, representing typical anatomies of patients with cavo-pulmonary connections (28–33). More recently, the use of tomographic medical imaging techniques, such as MR and CT, has joined the well-established ultrasound and angiography imaging techniques and has allowed more realistic 3D reconstructions of a specific patient's vessels (34–39). …”

Section: Univentricular Circulation Modelingmentioning

confidence: 99%

Computational fluid dynamics models and congenital heart diseases

Pennati¹

2013

Front. Pediatr.

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Mathematical modeling is a powerful tool to investigate hemodynamics of the circulatory system. With improving imaging techniques and detailed clinical investigations, it is now possible to construct patient-specific models of reconstructive surgeries for the treatment of congenital heart diseases. These models can help clinicians to better understand the hemodynamic behavior of different surgical options for a treated patient. This review outlines recent advances in mathematical modeling in congenital heart diseases, the discoveries and limitations these models present, and future directions that are on the horizon.

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Patient-specific computational fluid dynamic simulation of a bilateral bidirectional Glenn connection

Cited by 12 publications

References 19 publications

Numerical Study of Bidirectional Glenn With Unilateral Pulmonary Artery Stenosis

Numerical Study of Bidirectional Glenn With Unilateral Pulmonary Artery Stenosis

Comparison of hemodynamics in post-operation coarctation of aorta patients with different aortic arch geometry

Computational fluid dynamics models and congenital heart diseases

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