Patient-specific computer simulation for transcatheter cardiac interventions: what a clinician needs to know

Abstract

Patient-specific computer simulation consists of the assessment of the interaction of the device with the host based on the integration of the detailed geometric and biomechanical properties of the device and host. Hence, it allows the prediction of valve performance (efficacy) and complications (safety) and may consequently help the physician to select the valve/device that best fits the individual patient, thereby improving outcome. There is currently little awareness and information in clinical medicine on patient-specific computer simulation. In this paper, we describe the technical background and a number of illustrations to illustrate how patient-specific computer simulation may be used for catheter-based treatment planning of acquired heart disease.

Growing up with congenital heart disease: impact on the daily life quality from the perspective of a mother

“…Improved medical imaging techniques and supercomputers are among the factors that have promoted innovative investigations. For example, in-vitro and in-silico fluid dynamics models of blood circulation have been built, from the simplest to the most complex, and have proved their reliability as tools for the assessment of diseases 17,18 , the development of safe and effective prosthetic devices 19,20 , and the presurgical planning 21 . The belief of the author of this report, who has a more than tenyear"s experience in the cardiovascular fluid dynamics field, is that fluid dynamics modelling shows its full potential when applied to congenital heart defects, which often occur with complex and/or patient-specific configurations that require ad-hoc analysis and detailed description 22,23 .…”

Evolving Paradigm of Precision Medicine in Cardiovascular Disease.

“…The FEops HEARTguide integrates CT imaging with tissue and device characteristics to simulate device-host interactions and predict calcium displacement, device deformity, residual periprosthetic leak and occurrence of conduction abnormalities secondary to focal pressure phenomena in patients who undergo transcatheter aortic valve implantation (TAVI) for severe aortic stenosis. Computational modelling helps to identify and select the best device for a specific anatomy, whether it is in the coronary or structural heart space [62,63].…”

The history of transcatheter aortic valve implantation: The role and contribution of an early believer and adopter, the Netherlands

“…2 and 3. Beyond the analysis of outcomes and the underlying mechanisms in single, multicentre national and international initiatives and collaborations, research has been initiated to elucidate and predict the interaction between the device and host as well as the role of Artificial Intelligence in TAVI [26][27][28][29][30][31][32][33][34][35]. The clinical drive of innovation providing the best possible care to the individual patient and the scientific work (volume and content) of all Dutch medical professionals is an expression of the stimulating environment in which they have the pleasure to live and work.…”