Patient-Specific Computer Simulation in TAVR With the Self-Expanding Evolut R Valve

Patient-Specific Computer Simulation to Predict Conduction Disturbance With Current-Generation Self-Expanding Transcatheter Heart Valves

“…40 Ideally, all patients would be considered for patient-specific computer simulation, as the usage of this technology has been demonstrated to alter procedural elements, such as target depth of implantation. 41 However, due to time and financial constraints, this technology might selectively be used for patients at high risk for conduction disturbance, such as those with pre-existing right bundle branch block (Figure 7), for patients with reduced left ventricular ejections, where permanent pacing may have deleterious long-term outcomes, or for patients with complex anatomy, such as bicuspid aortic valve. 37,[42][43][44] Furthermore, patient-specific computer simulation is just one of a number of potential precision medicine techniques that may be incorporated into transcatheter aortic valve implantation procedural planning, execution, and follow-up.…”

Oversizing of Self-Expanding Nitinol Vascular Stents – A Biomechanical Investigation in the Superficial Femoral Artery

“…In this context, simulation-based surgical planning could be used to predict potential complications due to the interaction of the device frame with a specific patient's anatomy. While personalized prediction models have already been developed for transcatheter aortic valve implantation to select the optimal device type and size (El Faquir et al, 2020;Gunning et al, 2014), only a few numerical models investigated the effects of oversizing for the treatment of femoral arteries (Gökgöl et al, 2015;Gökgöl et al, 2017). In addition to previous numerical studies on oversizing in SFAs, the computational framework here developed was supported through an experimental campaign that included standard benchmark tests (namely axial tension and radial compression) and was robustly validated with confined deployment in a mock vessel.…”

Transcatheter valvular therapies in patients with left ventricular assist devices

“…On the other hand, the accumulation of patient-specific data will be an opportunity to develop patient-specific simulation-based planning to help predict outcomes after THV interventions in this high-risk patient population. Promising computational models have already been applied to various branches of percutaneous cardiac procedures ( 127 – 129 ).…”