Patient-specific Ti-6Al-4V lattice implants for critical-sized load-bearing bone defects reconstruction

Benady, Amit; Meyer, J. Sam; Golden, Eran; Dadia, Solomon; Levy, Galit Katarivas

doi:10.1016/j.matdes.2023.111605

Cited by 16 publications

(10 citation statements)

References 49 publications

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“…By closely resembling the mechanical properties of the surrounding bone, the implant can distribute mechanical forces more uniformly, enabling the bone to bear its intended load. This characteristic is vital in maintaining the structural integrity of the bone and preventing excessive bone resorption or weakening . Additionally, the absence of stress shielding effects facilitates optimal stress distribution, which promotes bone cell attachment and growth around the implant, potentially enhancing osseointegration .…”

Section: Discussionmentioning

confidence: 99%

“…This characteristic is vital in maintaining the structural integrity of the bone and preventing excessive bone resorption or weakening. 34 Additionally, the absence of stress shielding effects facilitates optimal stress distribution, which promotes bone cell attachment and growth around the implant, potentially enhancing osseointegration. 35 The axial compressive strength of human vertebral bone was reported as 2.270 ± 1.142 MPa.…”

Section: Discussionmentioning

confidence: 99%

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3D-Printed PEEK/Silicon Nitride Scaffolds with a Triply Periodic Minimal Surface Structure for Spinal Fusion Implants

Du,

Ronayne,

Lee

et al. 2023

ACS Appl. Bio Mater.

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The issue of spine-related disorders is a global healthcare concern that requires effective solutions to restore normal spine functioning. Spinal fusion implants have become a standard approach for this purpose, making it crucial to develop biomaterials and structures that possess high osteogenic capacities and exhibit mechanical properties and dynamic responses similar to those of the host bone. This study focused on the fabrication of 3D-printed polyether ether ketone/silicon nitride (PEEK/SiN) scaffolds with a triply periodic minimal surface (TPMS) structure, which offers several advantages, such as a large surface area and uniform stress distribution under load. The mechanical properties and dynamic response of PEEK/SiN scaffolds with varying porosities were evaluated through mechanical testing and finite element analysis. The scaffold with 30% porosity exhibited a compressive strength (34.56 ± 1.91 MPa) and elastic modulus (734 ± 64 MPa) similar to those of trabecular bone. In addition, the scaffold demonstrated favorable damping properties. The biological data revealed that incorporating silicon nitride into the PEEK scaffold stimulated osteogenic differentiation. In light of these findings, it can be inferred that PEEK/SiN TPMS scaffolds exhibit significant potential for use in bone tissue engineering and represent a promising option as candidates for spinal fusion implants.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

3D-Printed PEEK/Silicon Nitride Scaffolds with a Triply Periodic Minimal Surface Structure for Spinal Fusion Implants

Du,

Ronayne,

Lee

et al. 2023

ACS Appl. Bio Mater.

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“…Ti-6Al-4V implants have the potential to become the most effective method for regenerating significant bone defects, according to many results [21]. At the present time, total hip replacement stands as one of the most frequently conducted surgical procedures [22]. An approximated 15-20 years is the average lifespan of hip replacements or 75% by way of estimation.…”

Section: Intercalary Prosthesis Implant Materialsmentioning

confidence: 99%

Finite Element Analysis of New Designed Intercalary Prosthesis Implant (Ulna Bone)

Mustafa,

Shammari,

Augla

et al. 2024

alkej

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Implantation via an intercalary prosthetic method is a reliable solution for reconstructing a long defect in bones that has been damaged by severe disease or accidents. In the current study, using data from computed tomography (CT) scans, a novel costumed intercalary prosthesis design has been created. To achieve this purpose, the CT scan data of a patient in (DICOM) file format was converted into computer-aided design models and saved in stereolithography (STL) format using the 3D slicer (5.0.3) software. The STL files were loaded into Meshmixer software to design the models of the intercalary prosthesis. Finite element analysis (FEA) was applied to validate the strength of the prosthesis with impact, tensile testing, and torsional testing. According to the results of the impact tests, the highest recorded deformation was 8.8485e-002 m in the area where the implant body interfaces with the bone intramedullary canal, due to the high-stress (Von Mises Stress) value of 3.78 E9 PA. In the torsional loaded the highest deformation recorded was 1.3871e-008 m when the Von Mises stress reached 49006 PA, and with the application of the tensile test the largest deformation measured as 1.0458e-006 m at maximum Von Mises stress seen was recorded as 6.6012e+006 PA which caused that. A solid rod of Ti6Al4V alloy was selected. Finally, the analysis proved that the implant had enhanced mechanical properties. Based on the findings, it can be inferred that the prosthesis was successfully implanted, and a satisfactory result was obtained by using this design method.

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“…There are few clinical studies on the time it takes for bone to grow into porous Ti6Al4V constructs. A few studies reported that porous mandibular implants appeared to be stabilized in patients within three months [ 300 , 301 , 302 ]. In vivo, animal models suggest that this process could take up to 6 months [ 173 ].…”

Section: Challenges With the Clinical Application Of 3d-printed Mandi...mentioning

confidence: 99%

Titanium Alloy Implants with Lattice Structures for Mandibular Reconstruction

Hijazi,

Dixon,

Armstrong

et al. 2023

Materials

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In recent years, the field of mandibular reconstruction has made great strides in terms of hardware innovations and their clinical applications. There has been considerable interest in using computer-aided design, finite element modelling, and additive manufacturing techniques to build patient-specific surgical implants. Moreover, lattice implants can mimic mandibular bone’s mechanical and structural properties. This article reviews current approaches for mandibular reconstruction, their applications, and their drawbacks. Then, we discuss the potential of mandibular devices with lattice structures, their development and applications, and the challenges for their use in clinical settings.

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Patient-specific Ti-6Al-4V lattice implants for critical-sized load-bearing bone defects reconstruction

Cited by 16 publications

References 49 publications

3D-Printed PEEK/Silicon Nitride Scaffolds with a Triply Periodic Minimal Surface Structure for Spinal Fusion Implants

3D-Printed PEEK/Silicon Nitride Scaffolds with a Triply Periodic Minimal Surface Structure for Spinal Fusion Implants

Finite Element Analysis of New Designed Intercalary Prosthesis Implant (Ulna Bone)

Titanium Alloy Implants with Lattice Structures for Mandibular Reconstruction

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