Objectives: The aim of this study is to identify outpatients’ experiences of patient safety, patient satisfaction levels, and examine the factors influencing on patients’ satisfaction. Methods: Data from the Survey on the Experience with Healthcare Service in 2021 were used for this secondary analysis. Data from 6,027 patients aged over 20 who experienced outpatient health services in hospitals or clinics were analyzed. Logistic regression analysis was carried out to explore as influential factors which are patient characteristics, health-related characteristics, and their experiences of patient safety. Results: Generally, the level of patient satisfaction was high as 90.6% of participants were satisfied with the received outpatient care. High patient satisfaction was related to gender (females), job (housewives), education level (below secondary education level) and perceived health status (good status). Besides, those who experience being educated the side effects related to the medications or no checking the safety facilities of medical institutions were more likely to satisfy with the outpatient care. Conclusions: It is revealed that demographic and health-related characteristics, and patient safety experiences affected patients’ satisfaction with outpatient health services. To improve overall patients’ satisfaction with outpatient care, it is needed to enhance nonclinical patient safety activities such as explaining medication related side effects for patients.