2014
DOI: 10.1016/j.bbmt.2013.11.009
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Patient, Virus, and Treatment-Related Risk Factors in Pediatric Adenovirus Infection after Stem Cell Transplantation: Results of a Routine Monitoring Program

Abstract: Human adenovirus (HAdV) infection after hematopoietic stem cell transplantation (HSCT) is associated with significant morbidity and mortality in children. The optimal surveillance and treatment strategies are under discussion. Here, we present data from 238 consecutive pediatric allogeneic HSCT recipients who underwent transplantation in a single center who were included in a prospective, weekly HAdV DNAemia monitoring program by quantitative PCR. HAdV loads >1000 copies/mL were detected in 15.5% of all patien… Show more

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Cited by 84 publications
(109 citation statements)
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“…7,8 Adenovirus-associated mortality was minimized in our cohort as has been in other studies with routine monitoring, and pre-emptive use of cidofovir with detection of adenoviremia. 8 Novel cellular therapy approaches have been developed to treat adenoviremia. 9 However they are limited by a turn-around time of several weeks.…”
Section: Discussionmentioning
confidence: 62%
See 1 more Smart Citation
“…7,8 Adenovirus-associated mortality was minimized in our cohort as has been in other studies with routine monitoring, and pre-emptive use of cidofovir with detection of adenoviremia. 8 Novel cellular therapy approaches have been developed to treat adenoviremia. 9 However they are limited by a turn-around time of several weeks.…”
Section: Discussionmentioning
confidence: 62%
“…Types A31, C1 and C2 have been noted to be predominant in pediatric HSCT patients. 2,7,8,17 Multiple serotypes including A31 have been detected by sequential analysis. Infection is most likely due to viral reactivation in the epithelial and lymphoid cells of the intestine rather than from exogenous spread.…”
Section: Discussionmentioning
confidence: 99%
“…The cutoff for positivity for EBV and ADV were PCR levels above these thresholds of detection. This was similar to cutoffs used in published studies [16,22]. Post-transplantation viremia was defined as very early (day 0–14), early viremia (day 15–98), and late viremia (day 99–180).…”
Section: Methodsmentioning
confidence: 85%
“…A number of studies have addressed the antiadenoviral effect of cidofovir, but results are highly variable, with treatment successes ranging from 24% to 98% [16][17][18][19][20][21][22]. The discrepancies in cidofovir's effectiveness might be related to the fact that HAdV viremia and cidofovir treatment generally occur during the critical phase of lymphocyte reconstitution after HSCT [4][5][6][7].…”
Section: Introductionmentioning
confidence: 99%