Patient Willingness to Use Digital Health Technologies: A Quantitative and Qualitative Survey in Patients with Cancer Cachexia

Tarachandani, Anil; Karahanoğlu, Fikret Işık; Messere, Andrew; Tarasenko, Lisa; LaRonde-Richard, Ann-Marie; Kessler, Nancy; Rossulek, Michelle; Plate, Hans; Mahoney, Kim; Santamaria, Mar

doi:10.2147/ppa.s396347

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Having to wear a device in the lumbar region for weeks or months may not be ideal for patients. On the other hand, wrist-worn devices have been shown to offer better compliance when compared with lumbar-worn devices due to ease and comfort of wear resulting in lower patient burden [34,35], and therefore may be preferred by patients [36]. Choosing the right sensor location based on cohort and study design to obtain the endpoints of interest while maintaining operational simplicity is critical for successful deployment in clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Can Gait Characteristics Be Represented by Physical Activity Measured with Wrist-Worn Accelerometers?

Lin,

Karahanoglu,

Psaltos

et al. 2023

Sensors

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Wearable accelerometers allow for continuous monitoring of function and behaviors in the participant’s naturalistic environment. Devices are typically worn in different body locations depending on the concept of interest and endpoint under investigation. The lumbar and wrist are commonly used locations: devices placed at the lumbar region enable the derivation of spatio-temporal characteristics of gait, while wrist-worn devices provide measurements of overall physical activity (PA). Deploying multiple devices in clinical trial settings leads to higher patient burden negatively impacting compliance and data quality and increases the operational complexity of the trial. In this work, we evaluated the joint information shared by features derived from the lumbar and wrist devices to assess whether gait characteristics can be adequately represented by PA measured with wrist-worn devices. Data collected at the Pfizer Innovation Research (PfIRe) Lab were used as a real data example, which had around 7 days of continuous at-home data from wrist- and lumbar-worn devices (GENEActiv) obtained from a group of healthy participants. The relationship between wrist- and lumbar-derived features was estimated using multiple statistical methods, including penalized regression, principal component regression, partial least square regression, and joint and individual variation explained (JIVE). By considering multilevel models, both between- and within-subject effects were taken into account. This work demonstrated that selected gait features, which are typically measured with lumbar-worn devices, can be represented by PA features measured with wrist-worn devices, which provides preliminary evidence to reduce the number of devices needed in clinical trials and to increase patients’ comfort. Moreover, the statistical methods used in this work provided an analytic framework to compare repeated measures collected from multiple data modalities.

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Section: Introductionmentioning

confidence: 99%

Can Gait Characteristics Be Represented by Physical Activity Measured with Wrist-Worn Accelerometers?

Lin,

Karahanoglu,

Psaltos

et al. 2023

Sensors

Self Cite

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“It gave me a sense of achievement and a sense of purpose”—a qualitative study of patient experiences of a virtually supervised exercise program for adults with advanced cancer and cachexia

Bland,

France-Ratcliffe,

Krishnasamy

et al. 2024

Support Care Cancer

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Patient and carer experiences of cancer cachexia and its management

Bowers,

Higginson,

Maddocks

2024

Current Opinion in Supportive &Amp; Palliative Care

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Purpose of review To explore the contributions of recent qualitative literature in progressing understanding of the experiences of cancer cachexia, and its management, from the perspectives of patients and unpaid/family carers. Recent findings Challenges with conducting everyday activities, maintaining independence, and continuing usual roles within the family are sources of distress. Patients and carers value individualization, flexibility, and carer involvement in physical activity/exercise interventions. In psychosocial/educational interventions that were positively perceived, the opportunity to talk about cachexia was appreciated, leading to improved health literacy, awareness about nutrition, and relationships with food. However, the general patient and carer experience around clinical acknowledgement and management of cachexia remains poor. Summary Eating-related distress and conflicts, lack of understanding about cachexia, and the visibility of weight loss remain recurring themes amongst literature on experiences of cancer cachexia. Studies exploring preferences for, and experiences of, interventions have primarily focused on physical activity or exercise. Psychosocial/educational and physical activity/exercise interventions are valued and perceived to alleviate some of the key quality of life issues amongst patients with cancer cachexia and their unpaid/family carers.

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Patient Willingness to Use Digital Health Technologies: A Quantitative and Qualitative Survey in Patients with Cancer Cachexia

Cited by 3 publications

References 37 publications

Can Gait Characteristics Be Represented by Physical Activity Measured with Wrist-Worn Accelerometers?

Can Gait Characteristics Be Represented by Physical Activity Measured with Wrist-Worn Accelerometers?

“It gave me a sense of achievement and a sense of purpose”—a qualitative study of patient experiences of a virtually supervised exercise program for adults with advanced cancer and cachexia

Patient and carer experiences of cancer cachexia and its management

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