Patient with Down syndrome and implant therapy: a case report

Abstract

Patients with Down syndrome may not be cooperative during dental treatment and, in cases of complex treatment, it is necessary to use oral or inhaled sedation and/or general anesthesia, which represent safe and efficient treatment resources. There are few reports about oral rehabilitation with dental implants in patients with Down syndrome in the literature. This paper presents the case of a patient with Down syndrome and moderate mental retardation who suffered avulsion of the maxillary left central incisor after a fall, and was treated by means of a single dental implant with immediate load carried out under general anesthesia. After 4 years of follow up, there has been improvement in the sleep obstructive apnea syndrome due to the use of a tongue crib adapted for providing esthetics and preserving the implant placed.

Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction

“…Recently, some progress was achieved in targeting the mammalian ARS for the treatment of human diseases. Febrifugine derivatives, including halofuginone, target prolyl-tRNA synthetase, and many laboratories study them in connection with the possibility of treatment of cancer, fibrosis, and inflammatory diseases 31,32 . Threonyl-tRNA synthetase was identified as a target protein of anti-angiogenic borrelidin 33 , and a peptide fragment derived from tryptophanyl-tRNA synthetase is gaining interest as a possible anti-angiogenic agent 34 .…”

Is There Anything to Smile about? A Review of Oral Care for Individuals with Intellectual and Developmental Disabilities

“…While access to dental care services presents its own challenges, individuals with I/DD vary considerably in their abilities to cooperate in the dental setting and treatment is usually more difficult when services are obtained. Physical or cognitive challenges may make performance and participation in oral hygiene difficult, including various behaviors like biting down on the toothbrush, refusing to open wide, or at all [16, 25, 27, 28]. It is also possible that their carers may have difficulty understanding or lack the physical ability to perform personal oral health preventive practices.…”

“…Since the mid-1970s approximately two-thirds of individuals previously living in institutions were moved into the community. Researchers point out that access to dental care services was exacerbated by this deinstitutionalization movement, as once available services became unavailable in the new community locations [16, 27]. Further complicating the issue was the lack of dental providers trained to address the special needs of this population coupled with reimbursement or limited third-party support for complex services [16, 20, 29].…”

“…The study concludes that if oral health disparities and access issues are to be addressed for this particular group, future research needs to focus on developing best practices in educational efforts and dental programs [32]. A review of clinical services in the UK also supports the need for special programs and the need to develop a specialized workforce to serve the needs of the most vulnerable sectors of the community currently being provided by a relatively small number of socially committed dentists [27]. …”

“…Clearly people with I/DD have difficulty obtaining dental care, and even some believe that dental practices in the US actively discriminate against people with disabilities, likely because they have a disability that makes the health care professional uncomfortable [27, 32]. …”