Patient with Metastatic Breast Cancer Achieves Stable Disease for 5 Years on  Graviola and Xeloda after Progressing on Multiple Lines of Therapy

Hansra, Damien Mikael; Silva, Orlando; Mehta, Ashwin; Ahn, Eugene

doi:10.4236/abcr.2014.33012

Cited by 37 publications

(29 citation statements)

References 15 publications

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Section: Resultsmentioning

confidence: 99%

“…As presented in Table , a range of human studies including RCTs ( n = 3), double‐blind RCT ( n = 1) and a case report ( n = 1) were conducted for a duration of one to nine months utilising an oral ethanolic leaf extract at a range of doses from 180 to 540 mg daily. One case report used dry A. muricata leaves boiled in water . These studies evaluated the pharmacological effects of an A. muricata leaf extract in people with diabetes ( n = 1), breast cancer ( n = 1) and colorectal cancer ( n = 3) .…”

Section: Resultsmentioning

confidence: 99%

“…[24] One in-vitro study also demonstrated that the constituents of A. muricata were not actively transported by p-glycoprotein. [46] As presented in Table 5, a range of human studies including RCTs (n = 3), [8,9,47] double-blind RCT (n = 1) [48] and a case report (n = 1) [49] were conducted for a duration of one to nine months utilising an oral ethanolic leaf extract at a range of doses from 180 to 540 mg daily. One case report used dry A. muricata leaves boiled in water.…”

Section: Chemopreventive Potentialmentioning

confidence: 99%

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The safety and tolerability of Annona muricata leaf extract: a systematic review

Chan

McLachlan

Hanrahan

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Annona muricata, also known as graviola, soursop and guanabana, has been widely utilised for the treatment of a range of cancers. The mechanism of action and the efficacy of A. muricata and its constituents in the treatment of cancer have been comprehensively reviewed. The aim of this systematic review was to summarise the available literature that reports on factors related to the safety and tolerability of A. muricata leaf extract and its acetogenins. Methods In‐vitro, preclinical animal studies and human studies of any design written in any language were included. Studies that evaluated A. muricata leaf extract and its constituents were searched through the databases Pubmed, Medline and Embase from inception to April 2019. The elaborated item 4 of Consolidated Standards of Reporting Trials statement and Animals in Research: Reporting In vivo Experiments guidelines were used to evaluate the quality of the studies. Key findings The results suggest that A. muricata and its constituents have hepatoprotective, neurotoxic, antinociceptive, anti‐ulcerative and chemopreventive effects. The dose and duration used in animal studies demonstrating toxicity may not directly translate into the effects in humans. Studies included in this review were judged to be of medium to high quality. Conclusions The overall outcome of the current review suggests that A. muricata has a favourable safety and tolerability profile. Future studies investigating its use in people diagnosed with a range of cancers are warranted.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Chemopreventive Potentialmentioning

confidence: 99%

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The safety and tolerability of Annona muricata leaf extract: a systematic review

Chan

McLachlan

Hanrahan

et al. 2020

Journal of Pharmacy and Pharmacology

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“…Aside from in vivo and in vitro studies, other isolated case reports have provided evidence for similar anti-cancer effects. Hansra et al report a case of a 66-year-old female with metastatic breast cancer who achieved stabilization of her disease for 5 years by consuming dried graviola leaves boiled in water once a day in conjunction with oral capecitabine [16].…”

Section: Other Evidencementioning

confidence: 99%

Graviola in Metastatic Ovarian Cancer: A Case Report of Sustained Disease Stability

Beale¹,

Syed²,

Pham³

2019

COR

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A B S T R A C TTreatments for metastatic ovarian cancer to date have been limited by advanced stages at diagnosis, drug toxicity and resistance. Cancer patients are also increasingly looking towards complementary and alternative therapies. Graviola (Annona muricata) has traditionally been used in many conditions including cancer, and both in vivo and in vitro studies have shown evidence of anti-cancer effects. We present a case of a patient with metastatic ovarian cancer who progressed through multiple lines of chemotherapy but had a response and sustained stability in Ca-125 levels whilst taking graviola tablets. Further clinical research is warranted to evaluate graviola's role in cancer therapy.

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“…Not only in vitro but also in vivo investigations are limited to anticancer examination of A. muricata. A reported case study of 66-year-old woman having metastatic breast cancer resulted in the stabilization of this disease by the consumption of the leaves boiled in water and Xeloda [130].…”

Section: Allium Sativummentioning

confidence: 99%

Ethnopharmacological Review of Natural Products in Cancer Prevention and Therapy

Ayoub

Mehta

Mishra

2018

Asian J Pharm Clin Res

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The World Health Organization reports that approximately 80% population from developing countries are facing complications from synthetic drugs used in maintaining their primary health-care needs. The chemotherapeutic strategies are very striking and have earned serious concern as potential means of controlling the incidence of this dreadful disease. However, the major problem in cancer is the long lasting toxicity of the well reputable chemical drugs. Since ancient times, medicinal plants have attracted enormous attention, to fight against various diseases with their broad-spectrum biological and therapeutic properties. Although plants, phytochemicals and their analogues have been confirmed to be safe and effective, having strong anticancer properties. A number of pharmaceutical agents with diverse chemical structures of natural origin from plants have been discovered as anticancer agents such as vincristine, vinblastine, podophyllotoxin, camptothecin, taxol, resveratrol, withaferin A, quercetin, and curcumin. Further modifications of these phytochemicals led to the development of numerous outstanding molecules such as drugs like topotecan, irinotecan, taxotere, etoposide, and teniposide. In this in-depth review, we meticulously investigated the selected medicinal plants for their anticancer properties. In particular, novel compounds from plants have beneficial effects on human health. Our observations suggest the preventive and therapeutic use of phytochemicals in managing various human malignancies.

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Patient with Metastatic Breast Cancer Achieves Stable Disease for 5 Years on Graviola and Xeloda after Progressing on Multiple Lines of Therapy

Cited by 37 publications

References 15 publications

The safety and tolerability of Annona muricata leaf extract: a systematic review

The safety and tolerability of Annona muricata leaf extract: a systematic review

Graviola in Metastatic Ovarian Cancer: A Case Report of Sustained Disease Stability

Ethnopharmacological Review of Natural Products in Cancer Prevention and Therapy

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