“…Lifestyle modification focused on weight reduction, increased physical activity, and dietary change is advised as first-line therapy in a number of medical disorders, yet the success rate of enduring changes is exceedingly low, particularly when long-term outcome is considered [41,42]. A major difficulty is represented by the prolonged effort that is required, with frequent discouragement and frustration when unavoidable drawbacks occur [41]. A clinical state of demoralization may emerge during treatment of conditions such as type 2 diabetes and overweight/obesity [42,53,54], and the successful clinician is the one who recognizes and alleviates demoralization while treating the patient.…”