Background: Healthcare professionals are encouraged to promote concordance, a shared agreement about prescription and administration of medications, in their communication with patients. However, there is a paucity of research regarding the impact of communication about self-administered oral chemotherapy. The aim of this study was to examine the changing dynamics of communication through the patient journey from diagnosis of colorectal cancer to posttreatment of chemotherapy.Methods: Over 60 hours of observational data were digitally recorded from interactions between 15 healthcare professionals, eight patients with colorectal cancer prescribed capecitabine, and 11 family members over a 6-month period in outpatient departments within one hospital in the United Kingdom. Sixteen semi-structured interviews were conducted with patients during and after their treatment. Three focus groups were carried out with healthcare professionals. These data were analysed using thematic analysis.Results: The patient journey followed a path of four distinct phases: autocracy, physiological concordance, holistic concordance, and silence. Initially, communication was medicalised with patients occupying a passive role. As patients continued their journey, they took a more active role in their treatment discussion by leading consultations and sharing their priorities of care. At the end of treatment, patients felt isolated and unsupported when they were discharged from their oncology team.Conclusions: Communication about oral chemotherapy is not a static process; it evolves to take account of changing clinical requirements and growing patient confidence in dealing with their cancer. Different stages in the treatment journey indicate the need for different approaches to communication. KEYWORDS cancer, colorectal cancer, communication, ethnography, oncology, oral chemotherapy, patient education, patient experience, patient safety 1 | BACKGROUNDCancer is one of the leading causes of morbidity and mortality with more than 15 million new diagnoses each year. 1 Colorectal cancer is the third most common form of cancer, and its global burden is expected to increase by 60% to more than 2.2 million new cases and 1.1 million deaths by 2030. 2 Presently, the most common ways to treat colorectal cancer are surgery, radiotherapy, targeted therapy, chemotherapy, or a combination of these. 3 Over the past decade, administration of chemotherapy has changed with a growing number