Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplementation with antioxidants and essential fatty acids

Galbis-Estrada, Carmen; Pinazo-Durán, María Dolores; Cantu-Dibildox, Jorge; Marco-Ramírez, Carla; Díaz-Llópis, Manuel; Benítez-del-Castillo, Javier

doi:10.2147/cia.s43191

Cited by 33 publications

(40 citation statements)

References 49 publications

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“…Significantly increased levels of cytokines/chemokines have been detected in the tear fluid and conjunctiva of people with DED compared to normal eyes 46–50. Certain cytokines, such as interleukin 6, may induce cells to produce other compounds that play a role in the development of inflammation, such as prostaglandins, enzymes, and ROS 51. Tsubota et al52 recently suggested a new approach to the aging process and DED through controlling levels of calories and/or ROS in order to prevent DED.…”

Section: Oxidative Stress-related Ocular Pathologiesmentioning

confidence: 99%

Oxidative stress and its downstream signaling in aging eyes

Pinazo-Durán¹,

Gallego-Pinazo²,

García-Medina³

et al. 2014

CIA

Self Cite

109

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BackgroundOxidative stress (OS) and its biomarkers are the biochemical end point of the imbalance between reactive oxygen species (ROS) production and the ability of the antioxidant (AOX) biological systems to fight against oxidative injury.ObjectiveWe reviewed the role of OS and its downstream signaling in aging eyes.MethodsA search of the literature and current knowledge on the physiological and pathological mechanisms of OS were revisited in relation to the eyes and the aging process. Most prevalent ocular diseases have been analyzed herein in relation to OS and nutraceutic supplements, such as dry-eye disorders, glaucoma, age-related macular degeneration, and diabetic retinopathy.ResultsClinical, biochemical, and molecular data from anterior and posterior eye segment diseases point to OS as the common pathogenic mechanism in the majority of these ocular disorders, many of which are pathologies causing visual impairment, blindness, and subsequent loss of life quality. Studies with nutraceutic supplements in aging eye-related pathologies have also been reviewed.ConclusionOS, nutritional status, and nutraceutic supplements have to be considered within the standards of care of older ophthalmologic patients. OS biomarkers and surrogate end points may help in managing the aging population with ocular diseases.

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Section: Oxidative Stress-related Ocular Pathologiesmentioning

confidence: 99%

Oxidative stress and its downstream signaling in aging eyes

Pinazo-Durán¹,

Gallego-Pinazo²,

García-Medina³

et al. 2014

CIA

Self Cite

109

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“…Therefore, any alteration of the tear film may have direct consequences on the ocular surface integrity leading to pathological condition such as dry eye [ 7 , 8 ]. However, at the same time, any changes on the composition of the conjunctival sac fluid might have a potential as clinical biomarker to monitor the onset-evolution of ocular surface diseases [ 9 – 11 ] and the response to pharmacological and/or surgical interventions [ 12 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy

Tisato

Perri

Rimondi

et al. 2015

Mediators of Inflammation

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Photorefractive keratectomy (PRK) represents a therapeutic option to remodel corneal stroma and to compensate refractive errors, which involves inflammatory and/or regenerative processes. In this context, the modulation of cytokines/chemokines in the conjunctival sac fluid and their role in the maintenance of the corneal microenvironment during the healing process upon refractive procedures has not been deeply investigated. In this study, serial samples of conjunctival sac fluid of patients (n = 25) undergoing PRK were harvested before and at different time points after surgery. The levels of 29 cytokines/chemokines/growth factors involved in inflammatory/immune processes were measured with a multiplex array system. The results have firstly highlighted the different pattern of cytokine expression between the microenvironment at the anterior surface of the eye and the systemic circulation. More importantly, the kinetic of modulation of cytokines/chemokines at the conjunctival level following PRK revealed that while the majority of cytokines/chemokines showed a significant decrease, MCP-1 emerged in light of its pronounced and significant increase soon after PRK and during the follow-up. This methodological approach has highlighted the role of MCP-1 in the healing process following PRK and has shown a potential for the identification of expression/modulation of soluble factors for biomarker profiling in ocular surface diseases.

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“…In a randomized, double-blind trial of 45 patients with dry eye syndrome assigned to two capsules/day of omega-3 (each containing 180 mg eicosapentaenoic acid and 120 mg DHA) (n=33) or placebo (n=31) for 30 days, consumption of omega-3 fatty acids was associated with a decrease in the rate of tear evaporation, an improvement in dry eye symptoms, and an increase in tear secretion 14. In a study of patients on long-term treatment with antihypertensive eye drops with glaucoma and dry eye disorders, in which the oral supplement was Brudysec 1.5 g (the same as used in our patients), the main signs and symptoms of dry eye were significantly improved after 3 months of treatment as compared to unsupplemented patients 17. In a study by Oleñik et al22 in which the effect of Brudysec 1.5 g for 3 months was assessed in the treatment of dysfunction of the meibomian gland, the mean OSDI, tear breakup time, lid margin inflammation, and meibomian gland expression showed significant improvement from baseline values.…”

Section: Discussionmentioning

confidence: 55%

“…This study has been preceded by three other clinical trials 15,17,22. These clinical trials included limited samples of patients suffering OSD due to dry eye.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study

Oleñik

2014

OPTH

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BackgroundWe assessed the effectiveness and tolerability of a dietary supplement based on the combination of omega-3 essential fatty acids and antioxidants on dry eye-related symptoms.MethodsA total of 905 patients (72% women, median age 60 years) with dry eye syndrome and using artificial tears to relieve symptoms participated in an open-label prospective intervention study. They were recruited during a routine ophthalmological appointment. Patients were instructed to take three capsules/day of the nutraceutical formulation (Brudysec® 1.5 g) for 12 weeks. Dry eye symptoms (categorized as 0, none; 1, mild; 2, moderate; and 3, severe) included scratchy and stinging sensation in the eyes, eye redness, grittiness, painful eyes, tired eyes, grating sensation, and blurry vision.ResultsThe mean intensity of dry eye symptoms varied from 1.1 (± standard deviation [SD] 0.9) for painful eyes to 2.0 (0.9) for grittiness, with a mean value of 11.9 (4.8) for all symptoms together. At week 12, all individual symptoms improved significantly (P<0.001). The mean value for all symptoms together decreased from a mean value of 11.9 (± SD 4.8) at baseline to 6.8 (± SD 4.5) after 12 weeks of treatment (P<0.001). There was a decrease in the percentage of patients in which dry eye symptoms predominated nearly all the time (53.5% versus 34.1%). A total of 68.1% of patients reported better tolerance to contact lenses after treatment. The mean number of daily instillations of artificial tears also decreased significantly (3.8 [± SD 1.6] versus 3.3 [± SD 1.6], P<0.001). A total of 634 patients (70.1%) did not report any adverse events. In the remaining patients with adverse events, the most frequent was fish-tasting regurgitation in 13.5% of cases, followed by nausea in 4.9%, diarrhea in 1.3%, and vomiting in 0.3%.ConclusionDietary supplementation with a combination of omega-3 essential fatty acids and antioxidants was an effective treatment for dry eye.

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Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplementation with antioxidants and essential fatty acids

Cited by 33 publications

References 49 publications

Oxidative stress and its downstream signaling in aging eyes

Oxidative stress and its downstream signaling in aging eyes

Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy

Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study

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