Patients with a History of Elevated Prostate-Specific Antigen Levels and Negative Transrectal US–guided Quadrant or Sextant Biopsy Results: Value of MR Imaging

Beyersdorff, Dirk; Taupitz, Matthias; Winkelmann, Bjoern; Fischer, Thomas; Lenk, S; Loening, Stefan A.; Hamm, Bernd

doi:10.1148/radiol.2243011553

Cited by 157 publications

(99 citation statements)

References 25 publications

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“…Comet-Battle et al 25 had similar results, with a sensitivity of 80% and specificity of 76% using sextant PB for correlation. Beyersdorff et al 26 exhibited that T2-weighed e-MRI has increased diagnostic performance with a sensitivity of 83%. Yuen et al 27 exhibited a sensitivity and specificity of 82.1 and 100%, with a PCa detection rate of 29.2%.…”

Section: Discussionmentioning

confidence: 99%

Prostate cancer detection using an extended prostate biopsy schema in combination with additional targeted cores from suspicious images in conventional and functional endorectal magnetic resonance imaging of the prostate

Engelhard

Zugor

et al. 2009

Prostate Cancer Prostatic Dis

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The purpose of this study is to report our method in detecting prostate cancer (PCa) using an 18-core transrectal ultrasound (TRUS) prostate biopsy (PB) schema, in combination with additional targeted cores from suspicious images in conventional (e-cMRI) and functional (e-fMRI) endorectal magnetic resonance imaging (e-MRI) of the prostate. From 2004 to 2008, 260 consecutive patients with a clinical suspicion of PCa underwent PB and were prospectively studied. e-cMRI and e-fMRI was performed in all patients before PB. The patients were divided into two groups (A and B) according to the results of their radiological findings (group A ¼ suspicious findings, group B ¼ non-suspicious findings). After the images were processed, an 18-core TRUS-guided PB was performed. When a patient exhibited a suspicious site on e-cMRI and e-fMRI images, three additional targeted PBs were obtained from that site. In group A, 17.5% of PCa was detected by the 18-core PB and 56.5% of PCa was detected by the targeted cores. The overall PCa detection rate (18 þ targeted cores) was 73.9%. The overall specificity was 73.9%. In group B, overall false-positive detection rate reached 19.2%, with the overall sensitivity being 80.8%. The method described above is not only practical but also a promising modality in PCa detection. As seen, PCa was optimally detected when combining the 18-core and targeted-core PB schema together. Non-suspicious images do not rule out the probability of PCa, thus justifying a PB in these patients as well.

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Section: Discussionmentioning

confidence: 99%

Prostate cancer detection using an extended prostate biopsy schema in combination with additional targeted cores from suspicious images in conventional and functional endorectal magnetic resonance imaging of the prostate

Engelhard

Zugor

et al. 2009

Prostate Cancer Prostatic Dis

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“…DCE-MRI and MRS were mentioned as techniques that could be useful for staging, therapy planning and for detecting recurrent disease. The 2006 RCR guidance is currently being updated under the Cancer Staging Proforma Reporting Project (CASPAR), 44 which is a pilot programme to test the design and utility of proforma-based reporting for a number of cancers. The CASPAR PC imaging proforma provides guidance on the use of T2-MRI, DW-MRI and DCE-MRI (Dr Gina Brown, Project Lead, 27 February 2012, personal communication).…”

Section: Current Service Costmentioning

confidence: 99%

The diagnostic accuracy and cost-effectiveness of magnetic resonance spectroscopy and enhanced magnetic resonance imaging techniques in aiding the localisation of prostate abnormalities for biopsy: a systematic review and economic evaluation

Mowatt

Scotland²,

Boachie³

et al. 2013

Health Technol Assess

117

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Declared competing interests of authors: ARP has received reporting fees from Nuada Medical Prostate Care for patients with prostate cancer who were scanned at their medical facilities. JR has received consultancy honoraria and payment for lectures, expert testimony and travel/accommodation/meetings expenses from GlaxoSmithKline, and consultancy honoraria, payment for lectures and travel/ accommodation/meetings expenses from Ipsen. TS has received payment for travel/accommodation/ meeting expenses from multiple sources and his institution has received payment from Siemens Healthcare for a research collaboration. Published May 2013 DOI: 10.3310/hta17200This report should be referenced as follows:Mowatt G, Scotland G, Boachie C, Cruickshank M, Ford JA, Fraser C, et al. The diagnostic accuracy and cost-effectiveness of magnetic resonance spectroscopy and enhanced magnetic resonance imaging techniques in aiding the localisation of prostate abnormalities for biopsy: a systematic review and economic evaluation. Health Technol Assess 2013;17(20). This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/). Health Technology Assessment is indexed and abstracted inEditorial contact: nihredit@southampton.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: www.hta.ac.uk/ This reportThe research reported in this issue of the journal was funded by the HTA programme as project number 09/146/01. The contractual start date was in August 2010. The draft report began editorial ...

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“…With a sensitivity of 53.3%, a specificity of 60%, and an accuracy rate of 55%, TRUS is limited in the detection of tumor recurrence during the follow-up of prostate cancer patients who have undergone EBRT. Beyersdorff et al have compared digital examination, TRUS, and MRI, and they have found that the sensitivity of MRI (83%) in the detection of prostate cancer is higher than that of digital examination (67%) and TRUS (57%) (5 than TRUS in the detection of prostate cancer but is less specific than TRUS (6). Although these studies were not conducted with patients who were not treated with EBRT, several studies have also reported and shown that TRUS is unreliable for the detection of cancer recurrence after EBRT (7-9).…”

Section: Discussionmentioning

confidence: 99%

The role of dynamic contrast enhanced MRI in the detection of recurrent prostate carcinoma after external beam radiotherapy-correlation with transrectal ultrasound and pathological findings

Kara

Akata²,

Akyol³

et al. 2009

Diagn Interv Radiol

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Patients with a History of Elevated Prostate-Specific Antigen Levels and Negative Transrectal US–guided Quadrant or Sextant Biopsy Results: Value of MR Imaging

Abstract: In this patient population, MR imaging has higher sensitivity for detection of prostate cancer than DRE or transrectal US.

Cited by 157 publications

References 25 publications

Prostate cancer detection using an extended prostate biopsy schema in combination with additional targeted cores from suspicious images in conventional and functional endorectal magnetic resonance imaging of the prostate

Prostate cancer detection using an extended prostate biopsy schema in combination with additional targeted cores from suspicious images in conventional and functional endorectal magnetic resonance imaging of the prostate

The diagnostic accuracy and cost-effectiveness of magnetic resonance spectroscopy and enhanced magnetic resonance imaging techniques in aiding the localisation of prostate abnormalities for biopsy: a systematic review and economic evaluation

The role of dynamic contrast enhanced MRI in the detection of recurrent prostate carcinoma after external beam radiotherapy-correlation with transrectal ultrasound and pathological findings

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