Patients with Acromegaly Presenting with Colon Cancer: A Case Series

Gordon, Murray B.; Nakhle, Samer; Ludlam, W.H.

doi:10.1155/2016/5156295

Cited by 10 publications

(8 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In some studies, colon polyps and/or cancer have been reported to occur more frequently in acromegaly than in the general population, although data from other studies have not supported this association [ 49 , 50 ]. There is general agreement, however, that early colonoscopy screening and regular surveillance is justified [ 38 , 49 , 51 – 54 ]. The Screening Guidelines for Colorectal Cancer and Polyps in Acromegaly [ 52 ] recommend regular colonoscopic screening, starting at 40 years of age, with frequency of repeat colonoscopy depending on findings at original screening and acromegaly activity.…”

Section: Discussionmentioning

confidence: 99%

Screening for comorbid conditions in patients enrolled in the SODA registry: a 2-year observational analysis

et al. 2018

Self Cite

View full text Add to dashboard Cite

PurposeThis 2-year analysis assessed frequency of comorbidities and comorbidity screening in the Somatuline® (lanreotide, LAN) Depot for Acromegaly (SODA) registry.MethodsPatient data collected included pituitary hormone deficiencies, sleep studies, echocardiograms, gallbladder sonographies, colonoscopies, and glycated hemoglobin (HbA1c) levels. Insulin-like growth factor-1 (IGF-1) and growth hormone levels in patients with (DM) and without (non-DM) diabetes mellitus were analyzed.ResultsThere were 241 patients enrolled. Pituitary hormone deficiencies were reported more frequently at enrollment in male (56.9%) vs female patients (32.0%; p < 0.001). TSH deficiency was the most common endocrine deficiency (69.8%), followed by gonadotropin deficiency (62.3%). Screening tests reported at enrollment: sleep studies in 29.9% (79.2% had sleep apnea), echocardiogram in 46.1% (46.8% abnormal), gallbladder sonography in 18.7% (17.8% had gallstones), and colonoscopy in 48.1% (35.3% had polyps). Follow-up studies were reported less frequently at 1 and 2 years. HbA1c data were reported in 30.8% and 41.2% after 1 and 2 years. HbA1c levels were similar at 1 and 2 years of LAN therapy among DM and non-DM patients with available data. Fewer DM vs non-DM patients achieved IGF-1 below upper limit of normal at Month 24 (58.3% vs 80.6%; p = 0.033).ConclusionsFewer than half of patients in SODA had screening results reported at enrollment for sleep apnea, cardiomyopathy, and colon polyps. Gallbladder imaging was reported in a minority of patients. Lower IGF-1 control rates were observed in DM vs non-DM patients at Month 24. These data suggest a need for better monitoring of comorbidities in US acromegaly patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Screening for comorbid conditions in patients enrolled in the SODA registry: a 2-year observational analysis

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…The incidence of colorectal cancer is a complex process that involves multiple factors. As the early clinical symptoms of colon cancer patients are not obvious, most patients are diagnosed at the advanced stage of colon cancer ( 10 ). The epigenetic changes also play a very important role in the incidence and development of colon cancer ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

Correlation between the methylation of APC gene promoter and colon cancer

Zhang

2017

Oncology Letters

View full text Add to dashboard Cite

The present study was planned to explore the correlation between the methylation of APC (adenomatous polyposis coli) and colon carcinogenesis. Colon cancer tissues and tumor-adjacent normal tissues of 60 colon cancer patients (who received surgical operation in our hospital from January 2012 to December 2014) were collected. SW1116 cells in human colon cancer tissues were selected for culturing. 5-aza-2c-deoxycytidine (5-aza-dC) was utilized as an inhibitor of the methylation for APC gene. Methylation specific PCR (MSP) was utilized for detection of APC methylation in SW1116 cells. The MTT and Transwell assays were performed to detect the effect of the methylation of APC gene on the proliferation and invasive abilities of SW1116 cells. The correlation between the methylation of APC gene and pathological parameters of colon cancer patients was analyzed. MSP results revealed that 41 cases (68.33%) showed methylation of APC gene in colon cancer tissues. No methylation of APC gene was found in tumor-adjacent normal tissues. 5-aza-dC was able to inhibit the methylation of APC gene in SW1116 cells. APC gene methylation was correlated with tumor size, differentiation degree, lymph node metastasis and Dukes staging. In conclusion, the levels of the methylation of APC in colon cancer tissues and SW1116 cells are relatively high. The methylation of APC promoted the proliferation and invasion abilities of SW1116 cells. Furthermore, methylation is correlated with a variety of clinicopathological features of colon cancer patients.

show abstract

“…Colon cancer is a malignant tumor with relatively higher incidence, and the incidence is on the increase annually in China due to the change in eating habits ( 11 ). Due to the absence of any obvious early clinical symptoms, many patients with colon cancer are usually diagnosed when the disease is already in late-stage and is already too late for surgical intervention ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

Treatment mechanism of matrine in combination with irinotecan for colon cancer

Duan

Deng

Da-bin³

et al. 2017

Oncology Letters

View full text Add to dashboard Cite

The inhibitory effect of matrine (MA) was studied in combination with irinotecan (CPT-11) on proliferation of human colon carcinoma cell line HT29. We also explored the mechanism of cell apoptosis induction in HT29. HT29 cells were treated with different concentrations of MA and CPT-11 alone and in combination. The growth inhibition in HT29 cells was evaluated using MTT assay. Apoptosis was detected using AV-PI double staining flow cytometry. Transmission electron microscopy was used to detect structural changes in cells. Topoisomerase (TOPO) I, Bax and Caspase-3 expression levels were evaluated using western blot analysis. MA and CPT-11 alone and in combination, inhibited the proliferation of HT29 cells, whereas the combination treatment exhibited higher inhibitory effect (P<0.01). This suggests the existence of synergistic cytotoxicity. Compared with each treatment alone, the combination treatment caused more significant damage to cell structure, and caused a significantly higher apoptosis rate (P<0.01). Additionally, the combination treatment increased TOPO I, Bax and Caspase-3 expression levels (P<0.01). In conclusion, MA in combination with CPT-11 synergistically inhibited HT29 cell proliferation and induced apoptosis in these cells. The mechanism may be related to upregulation of the TOPO I, Bax and Caspase-3 protein expression.

show abstract

Patients with Acromegaly Presenting with Colon Cancer: A Case Series

Cited by 10 publications

References 18 publications

Screening for comorbid conditions in patients enrolled in the SODA registry: a 2-year observational analysis

Screening for comorbid conditions in patients enrolled in the SODA registry: a 2-year observational analysis

Correlation between the methylation of APC gene promoter and colon cancer

Treatment mechanism of matrine in combination with irinotecan for colon cancer

Contact Info

Product

Resources

About