Patients with Ankylosing Spondylitis Have Evidence of Left Ventricular Asynchrony

Kırış, Abdülkadir; Karkucak, Murat; Karaman, Kayıhan; Kırış, Gülhanım; Çapkın, Erhan; Gökmen, Ferhat; Kutlu, Merih; Çelık, Şükrü; Ayar, Ahmet

doi:10.1111/j.1540-8175.2012.01665.x

Cited by 9 publications

(2 citation statements)

References 41 publications

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“… 5 Involvement of myocardium also reported, yet is not frequently encountered and remains less well recognized. 6 , 7 Recently presence of left ventricular asynchrony has been shown in patients with ankylosing spondylitis. 6 Cardiac involvement occurs more frequently in long-standing disease however they can precede skeletal symptoms.…”

Section: Discussionmentioning

confidence: 99%

“… 6 , 7 Recently presence of left ventricular asynchrony has been shown in patients with ankylosing spondylitis. 6 Cardiac involvement occurs more frequently in long-standing disease however they can precede skeletal symptoms. 7 The prevalence of dilated cardiomyopathy in patients with ankylosing spondylitis is under-reported because it symptoms such as dyspnea on exertion may be attributed to the underlying disease.…”

Section: Discussionmentioning

confidence: 99%

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Left ventricular non-compaction in a patient with ankylosing spondylitis

Toufan¹,

Pourafkari²,

Nader³

2016

J Cardiovasc Thorac Res

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A 58 years old male with a long-standing history of HLA-B27 positive ankylosing spondylitis presented with increasing fatigue and dyspnea on exertion. He had left ventricular dysfunction and enlargement, flail right coronary leaflet of aortic valve with severe eccentric aortic insufficiency along with left ventricular non-compaction in echocardiography. The most common cardiac manifestations of ankylosing spondylitis are aortic insufficiency and conduction disturbances. Involvement of myocardium, in the form of dilated cardiomyopathy and restrictive cardiomyopathy, has also been reported. This case presents a very rare association of ankylosing spondylitis with non-compaction cardiomyopathy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Left ventricular non-compaction in a patient with ankylosing spondylitis

Toufan¹,

Pourafkari²,

Nader³

2016

J Cardiovasc Thorac Res

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Cardiovascular and Cerebrovascular Diseases in Ankylosing Spondylitis: Current Insights

2012

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Patients with ankylosing spondylitis (AS) suffer from an increased cardiovascular (CV) risk. The evidence for increased atherosclerotic disease is nowadays convincing, while the precise contribution of the so-called AS-specific (related) cardiac manifestations toward the increased CV risk still needs to be determined. Such studies should be performed in the near future, since they might have clinical consequences-for example, mandatory echocardiographic screening of AS patients. There appears to be a clear contribution of the "traditional" CV risk factors, as well as the underlying chronic inflammatory process, to the increased atherosclerotic risk in AS. Furthermore, there is accumulating evidence for an etiological role of inflammation in the AS-related cardiac manifestations. Nowadays, CV risk management appears necessary for AS patients, and this should consist of, on the one hand, assessment and treatment, if necessary, of the "traditional" CV risk factors, and, on the other hand, effective suppression of the inflammatory process.

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Left ventricular synchronicity is impaired in patients with active acromegaly

et al. 2012

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Acromegaly is associated with a variety of cardiovascular disturbances such as left ventricular hypertrophy, diastolic cardiac dysfunction, and hypertension. Left ventricular (LV) dyssynchrony means the impairment of synchronicity and is defined as the loss of the simultaneous peak contraction of corresponding cardiac segments. The objective of this study was to investigate whether acromegalic patients have left ventricular dyssynchrony. Dyssynchrony was evaluated in 30 patients with active acromegaly and 30 controls. All the patients and controls were subjected to a tissue synchronization imaging. The time to regional peak systolic tissue velocity (Ts) in LV by the six-basal-six-mid-segmental model was measured on ejection phase TSI images and four TSI parameters of systolic dyssynchrony were computed. All TSI parameters of LV dyssynchrony increased in patients with acromegaly compared to the controls: the standard deviation (SD) of the 12 LV segments Ts (43.5 ± 13.5 vs 26.2 ± 12.5, p < 0.001); the maximal difference in Ts between any 2 of the 12 LV segments (133.3 ± 38 vs 84.6 ± 37.6, p < 0.001); the SD of the 6 basal LV segments (41.1 ± 15.9 vs 25.4 ± 14.8, p = 0.001); and the maximal difference in Ts between any 2 of the 6 basal LV segments (102.6 ± 37.5 vs 65.2 ± 36.9, p = 0.001). In addition, there were significant relationships between the levels of growth hormone/insulin-like growth factor-1 and Ts-SD-12. LV synchronicity has been impaired in patients with acromegaly. Left ventricular dyssynchrony is associated with disease activity and it may contribute to the harmful cardiovascular effects of acromegaly.

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Patients with Ankylosing Spondylitis Have Evidence of Left Ventricular Asynchrony

Abstract: TSI showed presence of LV systolic asynchrony in patients with AS which may account for the cardiovascular complications of AS.

Cited by 9 publications

References 41 publications

Left ventricular non-compaction in a patient with ankylosing spondylitis

Left ventricular non-compaction in a patient with ankylosing spondylitis

Cardiovascular and Cerebrovascular Diseases in Ankylosing Spondylitis: Current Insights

Left ventricular synchronicity is impaired in patients with active acromegaly

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