Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin

Rosa, Joel Correa da; Malajian, Dana; Shemer, Avner; Rozenblit, Mariya; Dhingra, Nikhil; Czarnowicki, Tali; Khattri, Saakshi; Ungar, Benjamin; Finney, Robert; Xu, Hui; Zheng, Xiuzhong; Estrada, Yeriel; Peng, Xiangyu; Suárez‐Fariñas, Mayte; Krueger, James G.; Guttman‐Yassky, Emma

doi:10.1016/j.jaci.2014.11.017

Cited by 59 publications

(61 citation statements)

References 62 publications

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“…In particular, nickel, rubber, and fragrances were associated with decreased expression of genes involved in Th-1 and Th-2 inflammation and increased Th-17 and IL-23 skewing [133]. While more research is needed on this topic, these results suggest that common skin contactants in the environment may specifically upregulate inflammatory responses.…”

Section: Irritants and Pruritogensmentioning

confidence: 85%

“…Finally, cutaneous exposure to some common contact allergens may specifically affect expression of critical genes involved in different inflammatory pathways [133]. In particular, nickel, rubber, and fragrances were associated with decreased expression of genes involved in Th-1 and Th-2 inflammation and increased Th-17 and IL-23 skewing [133].…”

Section: Irritants and Pruritogensmentioning

confidence: 99%

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Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

278

225

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Introduction-The etiology of atopic dermatitis (AD) is multifactorial with interaction between genetics, immune and environmental factors.Areas covered-We review the role of prenatal exposures, irritants and pruritogens, pathogens, climate factors, including temperature, humidity, ultraviolet radiation, outdoor and indoor air pollutants, tobacco smoke exposure, water hardness, urban vs. rural living, diet, breastfeeding, probiotics and prebiotics on AD.Expert commentary-The increased global prevalence of AD cannot be attributed to genetics alone, suggesting that evolving environmental exposures may trigger and/or flare disease in predisposed individuals. There is a complex interplay between different environmental factors, including individual use of personal care products and exposure to climate, pollution, food and other exogenous factors. Understanding these complex risk factors is crucial to developing targeted interventions to prevent the disease in millions. Moreover, patients require counseling on optimal regimens for minimization of exposure to irritants and pruritogens and other harmful exposures.

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Section: Irritants and Pruritogensmentioning

confidence: 85%

Section: Irritants and Pruritogensmentioning

confidence: 99%

Environmental risk factors and their role in the management of atopic dermatitis

Kantor

Silverberg

2016

Expert Review of Clinical Immunology

278

225

View full text Add to dashboard Cite

show abstract

“…In some instances, similarities make it challenging to distinguish between the diseases. Previous approaches to characterize and differentiate these diseases focused on transcriptomic profiling of skin biopsies . While this increased our mechanistic understanding of each disease, the invasive nature of skin biopsies prevents it from being incorporated into routine clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Identification of unique proteomic signatures in allergic and non‐allergic skin disease

Wang¹,

Suárez‐Fariñas

Estrada

et al. 2017

Clin Experimental Allergy

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Summary Background Atopic dermatitis (AD), psoriasis (PS), and contact dermatitis (CD) are common skin diseases, characterized by barrier disruption and systemic inflammation, with unique epidermal signatures and common inflammatory pathways identified by transcriptomic profiling. This study profiled proteomic signatures in serum from subjects with AD, PS, and CD compared with healthy controls (HC). Objective Identify unique proteomic signatures to distinguish between inflammatory diseases with similar epidermal disruption and overlapping epithelial inflammation. Methods Sera from 20 subjects with moderate to severe AD, 10 subjects with CD, 12 subjects with moderate to severe PS, 10 subjects with both AD and CD, and 10 HC with no history of skin disease was analysed using high‐throughput proteomic analysis that detects expression of 1129 protein targets. Protein expression was compared between disease and HC, and across diseases for statistical significance (fold change≥1.5 and false discovery rate≤0.05), to identify unique proteomic signatures for each disease. Results Complement C5A anaphylatoxin (C5A), lipopolysaccharide binding protein (LBP), C‐reactive protein (CRP), ILT‐4, C‐C motif ligand 18 (PARC), and sialic acid‐binding Ig‐like lectin 14 (SIG14) were significantly modulated in all three diseases compared with HC. We identified unique signatures for AD (Immunoglobulin E (IgE), thymus‐ and activation‐regulated chemokine (TARC) and macrophage‐derived chemokine (MDC)), CD (10 proteins), and PS (kynureninase (KYNU)). Proteomic profiling in subjects with both AD and CD identified additional dysregulated proteins compared with subjects with either condition alone, indicating an exacerbated inflammation reaction. Conclusions and Clinical Relevance Unique sera proteomic signatures may distinguish between inflammatory skin diseases despite similar epidermal barrier disruption and epithelial inflammation. This may provide insight into disease pathogenesis, diagnosis, and therapeutic intervention in difficult‐to‐treat subjects.

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“…Overall, lower magnitude responses were observed and fewer immune genes were differentially expressed in the petrolatum-occluded AD group compared with those in subjects without AD. Attenuation of genomic responses in patients with AD has also been observed in biopsy specimens from positive patch test skin reactions to common allergens, such as nickel and fragrance, 72 suggesting an overall immune hyporesponsiveness in the setting of AD. It has been proposed that differential immune skewing and impaired T-cell priming in patients with AD can mitigate responses to certain cutaneous stimuli.…”

Section: Discussionmentioning

confidence: 94%

Petrolatum: Barrier repair and antimicrobial responses underlying this “inert” moisturizer

Czarnowicki

Malajian

Khattri

et al. 2016

Journal of Allergy and Clinical Immunology

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133

108

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Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin

Cited by 59 publications

References 62 publications

Environmental risk factors and their role in the management of atopic dermatitis

Environmental risk factors and their role in the management of atopic dermatitis

Identification of unique proteomic signatures in allergic and non‐allergic skin disease

Petrolatum: Barrier repair and antimicrobial responses underlying this “inert” moisturizer

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