Patients with chronic kidney disease have a poorer prognosis of coronavirus disease 2019 (COVID-19): an experience in New York City

Yamada, Takayuki; Mikami, Takahisa; Chopra, Nitin; Miyashita, Hirotaka; Chernyavsky, Svetlana; Miyashita, Satoshi

doi:10.1007/s11255-020-02494-y

Cited by 40 publications

(46 citation statements)

References 4 publications

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“… 9 13 14 Although there has been no data regarding the association between these two variables, CKD patients are reported to exhibit immunity dysfunction, which may be associated with more severe lung injury. 15 Advanced CKD might be associated with higher adverse outcomes than early-stage CKD. Dialysis patients may be prone to higher risk of adverse outcomes among CKD patients.…”

Section: Discussionmentioning

confidence: 99%

Association between Chronic Kidney Disease or Acute Kidney Injury and Clinical Outcomes in COVID-19 Patients

Kang

Kim

et al. 2020

J Korean Med Sci

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Section: Discussionmentioning

confidence: 99%

Association between Chronic Kidney Disease or Acute Kidney Injury and Clinical Outcomes in COVID-19 Patients

Kang

Kim

et al. 2020

J Korean Med Sci

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“…In a large cohort of patients in New York City, patients with CKD and either atrial fibrillation, heart failure, or ischemic heart disease had a higher mortality rate. [42]. In an Italian cohort, 94 patients on hemodialysis with COVID-19 who were managed as either inpatient or outpatient had mortality rates of 42% and 8%, respectively [43].…”

Section: Chronic Kidney Disease (Ckd) and End-stage Kidney Disease (Ementioning

confidence: 99%

COVID-19 and the kidney: what we think we know so far and what we don’t

et al. 2020

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The novel coronavirus disease infection (COVID-19) outbreak that was declared a global pandemic in March 2020 had led to an internationally variable but concerning incidence of COVID-associated acute kidney injury (AKI), with prevalence reported as high as 46% in large cohorts of hospitalized patients. Variability in AKI may be explained by differences in traditional risk factors for AKI, heterogeneity among patient cohorts, and differences in racial and ethnic groups. Further, AKI requiring kidney replacement therapies (KRT) has been associated with increased mortality. Proposed mechanisms of kidney injury include direct viral-induced tubular or glomerular injury, sepsis-associated AKI, and thrombotic disease. Kidney pathology include acute tubular injury, glomerular fibrin thrombi, pigmented tubular casts, and collapsing focal segmental glomerulosclerosis. "Viral-like" particles have been observed in renal samples at electron microscopy and viral RNA has been identified in both glomerular and tubular compartments of kidney specimens, but the link between viral presence and injury remain unclear. Though the link between AKI and poor outcomes is clear, prevalence and outcomes of COVID-19 in patients with chronic kidney disease and end stage kidney disease has not yet been reported. In patients on immunosuppression like those with kidney transplants or glomerular disease, COVID-19 has presented a management dilemma. Herein, we review the existing literature on kidney disease in COVID-19 and discuss what remains to be learned.

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“…Patients with kidney disease, especially those receiving chronic dialysis treatment have enhanced risk of severe COVID-19 infection-related complications and poor prognosis including higher risk of hospitalization, intensive-care unit admission, mechanical ventilation, and death. [1,2] In addition to these direct effects, the pandemic may have indirect effects on the psychosocial health of patients on in-center chronic hemodialysis (HD), even if they are not infected with COVID-19. These effects may be particularly overwhelming in a patient population that already has a disproportionately high burden of symptoms such as depression and anxiety.…”

Section: Introductionmentioning

confidence: 99%

Psychosocial Impact of COVID-19 Pandemic on Patients with End-Stage Kidney Disease on Hemodialysis

et al. 2020

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Background: The Coronavirus Disease 2019 (COVID-19) may have a negative effect on the mental and social health of patients with end-stage kidney disease on chronic in-center hemodialysis (HD), who have a high burden of psychological symptoms at baseline and unavoidable treatment-related COVID exposures. The goal of our study was to assess the impact of the COVID-19 pandemic on the psychosocial health of patients on chronic in-center HD. Methods: Participants enrolled in the ongoing Technology Assisted Collaborative Care (TĀCcare) trial in Western Pennsylvania and New Mexico were approached for participation in a phone survey in May 2020. Data on the pandemic's effect on participants' physical and mental health, symptoms (such as anxiety, mood, loneliness, sleep and stress), food and housing security was collected. Results: Surveys were completed by 49 participants (mean age 56 years, 53% males, 18% African American, 20% American Indian, 22% Hispanic). Almost 80% of participants reported being moderately-to-extremely worried about the pandemic's effect on their mental/emotional health and interpersonal relationships. More than 85% of the participants were worried about obtaining their dialysis treatments due to infection risk from close contact in the dialysis facility or during transportation. Despite this, 82% of participants reported being not at all/slightly interested in trying home dialysis as an alternative option. Overall, 27% of the participants had clinical levels of depressive symptoms but only 12% had anxiety meeting clinical criteria. About 33% of participants reported poor sleep quality over the last month. Perceived stress was high in about 30% of participants and 85% felt overwhelmed by difficulties with COVID-19, although 41% felt that things were fairly/very often going their way. Conclusions: Our study provides preliminary insights into the psychosocial distress caused by the COVID-19 pandemic among a diverse cohort of patients receiving chronic hemodialysis who are participating in an ongoing clinical trial.

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Patients with chronic kidney disease have a poorer prognosis of coronavirus disease 2019 (COVID-19): an experience in New York City

Cited by 40 publications

References 4 publications

Association between Chronic Kidney Disease or Acute Kidney Injury and Clinical Outcomes in COVID-19 Patients

Association between Chronic Kidney Disease or Acute Kidney Injury and Clinical Outcomes in COVID-19 Patients

COVID-19 and the kidney: what we think we know so far and what we don’t

Psychosocial Impact of COVID-19 Pandemic on Patients with End-Stage Kidney Disease on Hemodialysis

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