Patients with end-stage renal disease requiring hemodialysis benefit from percutaneous coronary intervention after non-ST-segment elevation myocardial infarction

Fu, Yuan; Sun, Hao; Zuo, Kun; Guo, Zongsheng; Xu, Li; Chen, Mulei; Wang, Lefeng

doi:10.1007/s11739-021-02921-7

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…7 Previous studies have mostly focused on in-hospital and short-term mortality after discharge in ESKD patients with AMI. [8][9][10] However, studies regarding the long-term survival rates are rare. One study evaluated the mortality rates for up to 5 years in ESKD patients suffering from AMI in 1998, and a high mortality rate was reported.…”

Section: Introductionmentioning

confidence: 99%

The impact of end-stage kidney disease on mortality in patients after acute myocardial infarction: A nationwide study

Chiang

Hung

Tai

et al. 2023

Journal of the Chinese Medical Association

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Background: This study aimed to evaluate the impact of end-stage kidney disease (ESKD) on mortality in patients with first-time acute myocardial infarction (AMI). Methods: This was a retrospective nationwide cohort study. Patients diagnosed with first-time AMI between January 1, 2000, and December 31, 2012, were included. All patients were followed-up until death or December 31, 2012, whichever occurred first. A one-to-one propensity score matching technique was used to match patients with ESKD to those without ESKD of similar sex, age, comorbidities, and coronary intervention (including percutaneous coronary intervention [PCI] and coronary artery bypass grafting [CABG]). Kaplan-Meier cumulative survival curves were constructed to compare AMI patients with and without ESKD. Results: A total of 186 112 patients were enrolled and 8056 patients with ESKD were identified. Propensity score matched 8056 patients without ESKD were included in the comparison. Overall, the 12-year mortality rate was significantly higher in patients with ESKD than in those without ESKD (log-rank p < 0.0001), including the sex, age, and PCI and CABG subgroups. In Cox proportional-hazard regression analysis, ESKD was an independent risk factor for mortality after patients suffered from first-time AMI (hazard ratio, 1.77; 95% CI, 1.70-1.84; p < 0.0001). A forest plot for subgroup analysis revealed that in AMI patients, ESKD had a higher impact on mortality in male; younger age; without comorbidities such as hypertension, diabetes mellitus, peripheral vascular disease, heart failure, cerebrovascular accident, and chronic obstructive pulmonary disease; and receiving PCI and CABG subgroups. Conclusion: ESKD significantly increases the mortality risk in patients with first-time AMI, including both sexes, different ages, and whether PCI or CABG was performed. In patients with AMI, ESKD has a high impact on mortality in male, younger age, without comorbidities, and those undergoing PCI and CABG.

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Section: Introductionmentioning

confidence: 99%

The impact of end-stage kidney disease on mortality in patients after acute myocardial infarction: A nationwide study

Chiang

Hung

Tai

et al. 2023

Journal of the Chinese Medical Association

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Role of Invasive Strategy for Non–ST-Elevation Myocardial Infarction in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Fong,

Low,

Chan

et al. 2023

The American Journal of Cardiology

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Impact of Chronic Kidney Disease on the Processes of Care and Long‐Term Mortality of Non–ST‐Segment–Elevation Myocardial Infarction: A Nationwide Cohort Study and Long‐Term Follow‐Up

Weight,

Moledina,

Ullah

et al. 2024

JAHA

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Background A growing population of patients with chronic kidney disease (CKD) presents with non–ST‐segment–elevation myocardial infarction, although little is known about their longer‐term mortality. Methods and Results Using the MINAP (Myocardial Ischaemia National Audit Project) registry, linked to Office for National Statistics mortality data, we analyzed 363 559 UK patients with non–ST‐segment–elevation myocardial infarction, with or without CKD. Cox regression models were fitted, adjusting for baseline demographics. Compared with patients without CKD, patients with CKD were less frequently prescribed P2Y12 inhibitors (89% versus 86%, P <0.001) less likely to undergo invasive angiography (67% versus 41%, P <0.001) or percutaneous coronary intervention (41% versus 25%, P <0.001), and were less often referred to cardiac rehabilitation (80% versus 66%, P <0.001). Following non–ST‐segment–elevation myocardial infarction, patients with CKD had higher risk of 30‐day (adjusted hazard ratio [HR], 1.24 [95% CI, 1.20–1.29], 1‐year 1.47 [95% CI, 1.44–1.51]) and 5‐year mortality 1.55 (95% CI, 1.53–1.58) than patients without CKD (all P <0.001). Risk of mortality over the entire study period was highest in CKD Stage 5 (HR, 2.98 [95% CI, 2.87–3.10]), even after excluding mortality ≤30 days (HR, 3.03 [95% CI, 2.90–3.17]) ( P <0.001). There was no significant difference in proportion of deaths attributable to cardiovascular disease at 30 days (CKD; 76% versus no CKD; 76%), or 1 ‐year (CKD; 62% versus no CKD; 62%). Conclusions Patients with CKD were significantly less likely to receive invasive investigation or undergo percutaneous coronary intervention and had significantly higher risk of short‐ and longer‐term mortality. Risk of mortality increased with reducing CKD stage. Cardiovascular disease was the main cause of mortality in patients with CKD, but at comparable rates to the general population with non–ST‐segment–elevation myocardial infarction.

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Patients with end-stage renal disease requiring hemodialysis benefit from percutaneous coronary intervention after non-ST-segment elevation myocardial infarction

Cited by 3 publications

References 34 publications

The impact of end-stage kidney disease on mortality in patients after acute myocardial infarction: A nationwide study

The impact of end-stage kidney disease on mortality in patients after acute myocardial infarction: A nationwide study

Role of Invasive Strategy for Non–ST-Elevation Myocardial Infarction in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis

Impact of Chronic Kidney Disease on the Processes of Care and Long‐Term Mortality of Non–ST‐Segment–Elevation Myocardial Infarction: A Nationwide Cohort Study and Long‐Term Follow‐Up

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