Patients with Fibromyalgia and Chronic Fatigue Syndrome show increased hsCRP compared to healthy controls

Groven, Nina; Fors, Egil Andreas; Reitan, Solveig Klæbo

doi:10.1016/j.bbi.2019.06.010

Cited by 37 publications

(32 citation statements)

References 40 publications

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“…Significant positive correlations were also noted with markers of oxidative stress and inflammatory cytokine interleukin (IL)-6 in patients with Major Depressive Disorder [68]. CRP and TNF-α have also been found to be significantly higher in individuals with fibromyalgia compared to healthy controls [69,70] and have been found to correlate positively with pain and fatigue [71]. The relationship between oxidative stress and inflammatory changes is complex with both mechanisms being interdependent.…”

Section: Discussionmentioning

confidence: 99%

Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis

et al. 2020

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Fibromyalgia syndrome (FMS) is characterised by chronic widespread pain alongside fatigue, poor sleep quality and numerous comorbidities. It is estimated to have a worldwide prevalence of 1.78%, with a predominance in females. Treatment interventions for fibromyalgia have limited success, leading to many patients seeking alternative forms of treatment, including modifications to their diet and lifestyle. The effectiveness of dietary changes in fibromyalgia has not been widely researched or evaluated. This systematic review identified twenty-two studies, including 18 randomised control trials (RCTs) and four cohort studies which were eligible for inclusion. In total these studies investigated 17 different nutritional interventions. Significant improvements in reported pain were observed for those following a vegan diet, as well as with the low fermentable oligo di-mono-saccharides and polyols (FODMAP) diets. Supplementation with Chlorella green algae, coenzyme Q10, acetyl-l-carnitine or a combination of vitamin C and E significantly improved measures of pain. Interpretation of these studies was limited due to the frequent poor quality of the study design, the wide heterogeneity between studies, the small sample size and a high degree of bias. Therefore, there is insufficient evidence to recommend any one particular nutritional intervention for the management of fibromyalgia and further research is needed.

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Section: Discussionmentioning

confidence: 99%

Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis

et al. 2020

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“…It is reported that the higher concentration of serum CRP is related to atherosclerosis [25] and it is predictive of future cerebrovascular disease and cardiovascular [9]. Some scholars reported that hs-CRP was increased compared with healthy controls in patients with chronic fatigue syndrome [14]. Additionally, a series of studies has already established the relationship between hs-CRP and some diseases such as coronary artery disease [26], hypertension [27], stroke [28] and cancer [15].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, a series of studies recently manifested that an increase of hs-CRP may predict clinical outcome, mortality and recurrent events in stroke patients [11][12][13]. Meanwhile, Groven et al reported that chronic fatigue syndrome is strongly associated with increased levels of hs-CRP compared with healthy controls [14]. Park et al indicated that cancer-related fatigue possibly mediated by physiological morbidity by higher levels of circulating hs-CRP [15].…”

Section: Introductionmentioning

confidence: 99%

Elevated plasma high‐sensitivity C‐reactive protein at admission predicts the occurrence of post‐stroke fatigue at 6 months after ischaemic stroke

Liu

Wang

et al. 2020

Euro J of Neurology

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Background and purpose Post‐stroke fatigue (PSF) is a common neuropsychiatric affective symptom occurring after stroke. Evidence indicates activated inflammatory pathways are involved in modulating the stroke and fatigue. High‐sensitivity C‐reactive protein (hs‐CRP) is one of the most sensitive indicators of inflammation. Our aim was to estimate the association between plasma hs‐CRP and PSF after acute ischaemic stroke. Methods In all, 212 acute ischaemic stroke patients were consecutively recruited within the first 14 days after stroke onset and followed up for 6 months. Plasma hs‐CRP levels were assayed by enzyme linked immunosorbent assay. Fatigue severity was assessed using the Fatigue Scale for Motor and Cognitive Functions. A score ≥ 43 is defined as PSF. Results Sixty‐eight stroke patients (32.1%) were diagnosed with PSF at 6 months’ follow‐up. In the patients with PSF, plasma hs‐CRP levels were significantly higher compared with those in non‐PSF patients (t = −8.524, P ≤ 0.001). In multivariate analyses, plasma levels of hs‐CRP were independently associated with PSF at 6 months (odds ratio 3.435, 95% confidence interval 2.222–5.309; P ≤ 0.001) after adjusting other recorded variables. Based on the receiver operating characteristic curve, the optimal cut‐off value of plasma hs‐CRP levels as an indicator for the prediction of PSF was projected to be 0.52 mg/dl, which yielded a sensitivity of 77.9% and a specificity of 74.3%, with the area under the curve 0.794 (95% confidence interval 0.725–0.864; P ≤ 0.001). Conclusion Elevated plasma hs‐CRP levels at admission were associated with PSF 6 months after stroke, suggesting that these alterations might predict the development of PSF in stroke patients.

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“…In IBD, for example, microbial dysbiosis is suspected to promote gut leakage and bacterial translocation which, in turn, induces an abnormal immune response and subsequently initiates a pro-inflammatory status [19,20]. Dysfunction of T-/B-cell memory and natural killer cells [21,22], chronic activation of innate antiviral signaling pathways (e.g., protein kinase R), different anti-oxidative (e.g., glutathione peroxidase, catalase) as well as increased inflammatory markers (e.g., C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α)) [17,23], and increased activation of nuclear factor kappa beta (NF-κB) [24,25] are frequently described pathways in fatigue [1,26,27]. Interleukin (IL)-6, in particular, has been linked to fatigue and is even called the “sleep factor”, which could thus partly explain the characteristic tiredness [28] (p. 207).…”

Section: Anti-inflammatory Dietary Strategiesmentioning

confidence: 99%

Anti-Inflammatory Diets and Fatigue

2019

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Accumulating data indicates a link between a pro-inflammatory status and occurrence of chronic disease-related fatigue. The questions are whether the observed inflammatory profile can be (a) improved by anti-inflammatory diets, and (b) if this improvement can in turn be translated into a significant fatigue reduction. The aim of this narrative review was to investigate the effect of anti-inflammatory nutrients, foods, and diets on inflammatory markers and fatigue in various patient populations. Next to observational and epidemiological studies, a total of 21 human trials have been evaluated in this work. Current available research is indicative, rather than evident, regarding the effectiveness of individuals’ use of single nutrients with anti-inflammatory and fatigue-reducing effects. In contrast, clinical studies demonstrate that a balanced diet with whole grains high in fibers, polyphenol-rich vegetables, and omega-3 fatty acid-rich foods might be able to improve disease-related fatigue symptoms. Nonetheless, further research is needed to clarify conflicting results in the literature and substantiate the promising results from human trials on fatigue.

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Patients with Fibromyalgia and Chronic Fatigue Syndrome show increased hsCRP compared to healthy controls

Cited by 37 publications

References 40 publications

Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis

Dietary Interventions in the Management of Fibromyalgia: A Systematic Review and Best-Evidence Synthesis

Elevated plasma high‐sensitivity C‐reactive protein at admission predicts the occurrence of post‐stroke fatigue at 6 months after ischaemic stroke

Anti-Inflammatory Diets and Fatigue

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