Patients with functional bowel disorder have disaccharidase deficiency: A single-center study from Russia

Dbar, Saria R.; Akhmadullina, O V; Belostotskiy, Nikolai; Парфенов, А И; Bykova, S V; Bakharev, S. M.; Baulo, Elena V.; Babanova, Alexandra; Indeykina, L.Kh.; Кузьмина, Т. Н.; Kosacheva, Tatiana; Spasenov, Aleksey; Makarova, A A

doi:10.12998/wjcc.v9.i17.4178

Cited by 3 publications

(2 citation statements)

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“…In another study of 82 patients with a mix of functional diarrhea and constipation, a majority of patients expressed disaccharidase deficiency: 86.5% were lactase deficient, 48.7% were maltase deficient, 50% were sucrase deficient and 84.1% were gluco-amylase deficient [ 19 ]. Interestingly, 31.7% of these patients were deficient in all enzymes [ 20 ].…”

Section: Disaccharidase Deficiency In Adultsmentioning

confidence: 99%

Intestinal Disaccharidase Deficiency in Adults: Evaluation and Treatment

Viswanathan

Rao

2023

Curr Gastroenterol Rep

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Purpose of Review Disaccharidase deficiency in adults causes carbohydrate malabsorption, resulting in symptoms which significantly overlap with irritable bowel syndrome (IBS). This article discusses the diagnosis and treatment of disaccharidase deficiency within the context of recent literature. Recent Findings Disaccharidase deficiency in adults is more common than previously thought, which includes lactase, sucrase, maltase and isomaltase enzymes. Deficiency in disaccharidases, which are produced by the intestinal brush border, will interfere with the breakdown and absorption of carbohydrates and may result in abdominal pain, gas, bloating and diarrhea. Patients deficient in all 4 disaccharidases are known as having “pan-disaccharidase” deficiency, which has a distinct phenotype with more reported weight loss than patients deficient in one enzyme. IBS patients who do not respond to low FODMAP dietary restriction may have undiagnosed disaccharidase deficiency and may benefit from testing. Diagnostic testing methods are limited to duodenal biopsies, which is the gold standard, and breath testing. Dietary restriction and enzyme replacement therapy have been shown to be effective treatments in these patients. Summary Disaccharidase deficiency is an underdiagnosed condition in adults with chronic GI symptoms. Patients who do not respond to traditional treatment strategies for DBGI may benefit from testing for disaccharidase deficiency. Further studies delineating the distinctions between disaccharidase deficient patients and those with other motility disorders are needed.

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Section: Disaccharidase Deficiency In Adultsmentioning

confidence: 99%

Intestinal Disaccharidase Deficiency in Adults: Evaluation and Treatment

Viswanathan

Rao

2023

Curr Gastroenterol Rep

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“…These bacteria will break down and ferment lactose rapidly, producing large amounts of shortchain fatty acids and gas, which raises the osmotic pressure in the intestinal lumen, causing diarrhea [16]. Current research has found that functional dyspepsia, diarrheal irritable bowel syndrome, and AAD are associated with lactase deficiency [17][18][19]. Some lactase genecontaining bacteria (i.e.…”

Section: Introductionmentioning

confidence: 99%

Lactase bacteria in intestinal mucosa are associated with diarrhea caused by high-fat and high-protein diet

Zhou

Peng²,

Deng³

et al. 2022

BMC Microbiol

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Background Excessive fat and protein in food can cause diarrhea by disturbing the intestinal microecology. Lactase is a functional enzyme strongly associated with diarrhea, while lactase bacteria in the intestine are an important source of microbial lactase. Therefore, we reconnoiter the relationship between diarrhea induced by a high-fat and high-protein diet (HFHPD) and intestinal mucosal lactase bacteria from the perspective of functional genes. Result Operational Taxonomic Units (OTUs) were 23 and 31 in the normal group (NM) and model group (MD), respectively, and 11 of these were identical. The Chao1 and Observed specie indexes in the MD were higher than those in the NM, but this was not significant (P > 0.05). Meanwhile, the Principal coordinate analysis (PCoA) and Adonis test showed that the community structures of lactase bacteria in NM and MD were significantly different (P < 0.05). In taxonomic composition, lactase bacteria on the intestinal mucosa were sourced from Actinobacteria and Proteobacteria. Where Actinobacteria were higher in NM, and Proteobacteria were higher in MD. At the genus level, Bifidobacterium was the dominant genus (over 90% of the total). Compared to NM, the abundance of Bifidobacterium were lower in MD, while MD added sources for lactase bacteria of Rhizobium, Amycolatopsis, and Cedecea. Conclusions Our data demonstrate that HFHPD altered the community structure of lactase bacteria in the intestinal mucosa, decreased the abundance of the critical lactase bacteria, and promoted the occurrence of diarrhea.

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