Patients With Functional Somatic Syndromes—Fibromyalgia, Irritable Bowel Syndrome, Chronic Headaches, and Chronic Low Back Pain—Have Lower Outcomes and Higher Opioid Usage and Cost After Shoulder and Elbow Surgery

Masood, Raisa; Mandalia, Krishna; Moverman, Michael A.; Puzzitiello, Richard N.; Pagani, Nicholas R.; Menendez, Mariano E.; Salzler, Matthew J.

doi:10.1016/j.arthro.2022.12.028

Cited by 6 publications

(2 citation statements)

References 50 publications

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“…Although there is a consensus to reduce and sometime eliminate the use of opioids because of the ongoing opioid crisis and the documented associated risk of opioid use disorder in surgical patients, [ 4 ] most patients undergoing TKA are still prescribed a limited amount of opioids for breakthrough pain because evidence shows that the use of opioids facilitates immediate functional recovery following TKA [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Use of Nanotechnology as an Alternative to Opioids for Post-operative Pain Management Following TKA

Chelly,

Plakseychuk,

Schott

2023

jocr

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Introduction: In response to the current opioid crisis, there is a great interest to develop non-pharmacologic approaches to post-operative pain management for patients undergoing total knee arthroplasty (TKA). Case Report: We report a case of a patient whose post-operative pain following TKA was managed using the newly designed NeuroCuple™ device, a patch based on the use of nanotechnology. The NeuroCuple™ device was placed above the knee by the patient at home. The use of the NeuroCuple™ device allowed the patient completely avoid the use of any opioids at home. Conclusion: Our report suggests that the use of the NeuroCuple™ device may represent an interesting alternative to opioids for the peri-operative management of pain following a primary, unilateral TKA. Keywords: Primary knee arthroplasty, peri-operative pain management, nanotechnology.

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Section: Discussionmentioning

confidence: 99%

Use of Nanotechnology as an Alternative to Opioids for Post-operative Pain Management Following TKA

Chelly,

Plakseychuk,

Schott

2023

jocr

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“…Classic fibromyalgia symptoms often begin after a triggering event and progressively accumulate without eliciting occurrence. Fibromyalgia often occurs in women who also have tension headaches, irritable bowel syndrome, anxiety, and depression [ 1 , 2 , 3 ]. Currently, there is no cure for fibromyalgia, medication can only manage the symptoms.…”

Section: Introductionmentioning

confidence: 99%

Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model

Liao,

Yen,

Hsiao

et al. 2024

IJMS

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Pain is an unpleasant sensory and emotional experience accompanied by tissue injury. Often, an individual’s experience can be influenced by different physiological, psychological, and social factors. Fibromyalgia, one of the most difficult-to-treat types of pain, is characterized by general muscle pain accompanied by obesity, fatigue, sleep, and memory and psychological concerns. Fibromyalgia increases nociceptive sensations via central sensitization in the brain and spinal cord level. We used intermittent cold stress to create a mouse fibromyalgia pain model via a von Frey test (day 0: 3.69 ± 0.14 g; day 5: 2.13 ± 0.12 g). Mechanical pain could be reversed by eicosapentaenoic acid (EPA) administration (day 0: 3.72 ± 0.14 g; day 5: 3.69 ± 0.13 g). A similar trend could also be observed for thermal hyperalgesia. The levels of elements in the transient receptor potential V1 (TRPV1) signaling pathway were increased in the ascending pain pathway, including the thalamus, medial prefrontal cortex, somatosensory cortex, anterior cingulate cortex, and cerebellum. EPA intake significantly attenuated this overexpression. A novel chemogenetics method was used to inhibit SSC and ACC activities, which presented an analgesic effect through the TRPV1 downstream pathway. The present results provide insights into the role of the TRPV1 signaling pathway for fibromyalgia and its potential as a clinical target.

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Fibromyalgia syndrome is an independent predictor of increased complications, revision, and cost of admission within 180 days of total shoulder arthroplasty

Moore,

Guareschi,

Rogalski

et al. 2024

Seminars in Arthroplasty: JSES

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Patients With Functional Somatic Syndromes—Fibromyalgia, Irritable Bowel Syndrome, Chronic Headaches, and Chronic Low Back Pain—Have Lower Outcomes and Higher Opioid Usage and Cost After Shoulder and Elbow Surgery

Cited by 6 publications

References 50 publications

Use of Nanotechnology as an Alternative to Opioids for Post-operative Pain Management Following TKA

Use of Nanotechnology as an Alternative to Opioids for Post-operative Pain Management Following TKA

Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model

Fibromyalgia syndrome is an independent predictor of increased complications, revision, and cost of admission within 180 days of total shoulder arthroplasty

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