History is of one of the many disciplines that is considered as science, and which allows past events to be studied. This allows us to know about past facts, accompany their evolution, the origin of many concepts and terms, as well as errors and myths, allowing a comprehensive understanding of the present and learning to improve the future.The importance of history is such that it ends up determining the culture of many countries and also frames scientific disciplines. The great advances in knowledge of neurological function and its brain localization began in the nineteenth century. It is only recently that head injuries are classified by their neurological deficit rather than the type of skull fracture. This is not surprising, since most head injuries were treated by general surgeons who knew little about neurological examination. Although the illustrations in the early sixteenth century showed the anisocoria, this condition was not mentioned until three centuries later, when Jonathan Hutchinson first reported a dilated pupil on the same side as an intracranial clot, and pointed out that it was due to the compression of the third cranial nerve.