Patients with hypogeusia show changes in expression of T2R taste receptor genes in their tongues

Onoda, Keiko; Hirai, Ryoji; Takao, Kyoichi; Kokubun, Shinichiro; Ikeda, Minoru

doi:10.1002/lary.22368

Cited by 18 publications

(16 citation statements)

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“…Onoda et al32 previously investigated the expression frequency of TAS2Rs with the reverse transcriptase‐polymerase chain reaction (RT‐PCR) in taste‐disorder patients' samples obtained from foliate papillae. Using this technique, which has been patented in the United States,33 we showed that the TAS2R had a low expression frequency in the patients with taste disorders caused by zinc deficiency.…”

Section: Introductionmentioning

confidence: 99%

“…Here, to determine whether or not TAS2Rs and ENaC genes are expressed on the tongue in rats and assess how zinc affects expression of these genes, we investigated the changes in the expression of these genes by zinc deficiency and the effects of zinc on TAS2Rs expression frequency in rat tongue circumvallate papilla using the same method as that of Onoda et al32…”

Section: Introductionmentioning

confidence: 99%

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Effects of zinc deficiency and supplementation on gene expression of bitter taste receptors (TAS2Rs) on the tongue in rats

Sekine¹,

Takao²,

Yoshinaga³

et al. 2012

The Laryngoscope

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of zinc deficiency and supplementation on gene expression of bitter taste receptors (TAS2Rs) on the tongue in rats

Sekine¹,

Takao²,

Yoshinaga³

et al. 2012

The Laryngoscope

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“…[3][4][5][6][7] Type III taste cells are thought to be concerned in taste signal transduction. 8) Homeostasis of this taste-sensing system is important for maintenance of the physiological condition, especially the nutrition status. Onoda et al 9) reported decreased T2R expression in the tongue tissues of patients with hypogeusia, suggesting that altered expression levels of taste receptors may be a determinant of taste sensitivity.…”

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confidence: 99%

Oxaliplatin Alters Expression of T1R2 Receptor and Sensitivity to Sweet Taste in Rats

Ohishi

Nishida

Yamanaka

et al. 2016

Biological & Pharmaceutical Bulletin

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As one of the adverse effects of oxaliplatin, a key agent in colon cancer chemotherapy, a taste disorder is a severe issue in a clinical situation because it decreases the quality of life of patients. However, there is little information on the mechanism underlying the oxaliplatin-induced taste disorder. Here, we examined the molecular and behavioral characteristics of the oxaliplatin-induced taste disorder in rats. Oxaliplatin (4-16 mg/kg) was administered to Sprague-Dawley (SD) rats intraperitoneally for 2 d. Expression levels of mRNA and protein of taste receptors in circumvallate papillae (CP) were measured by real-time quantitative polymerase chain reaction (PCR) and immunohistochemistry, respectively. Taste sensitivity was assessed by their behavioral change using a brief-access test. Morphological change of the taste buds in CP was evaluated by hematoxyline-eosin (HE) staining, and the number of taste cells in taste buds was counted by immunohistochemical analysis. Among taste receptors, the expression levels of mRNA and protein of T1R2, a sweet taste receptor subunit, were increased transiently in CP of oxaliplatin-administered rats on day 7. In a brief-access test, the lick ratio was decreased in oxaliplatin-administered rats on day 7 and the alteration was recovered to the control level on day 14. There was no detectable alteration in the morphology of taste buds, number of taste cells or plasma zinc level in oxaliplatin-administered rats. These results suggest that decreased sensitivity to sweet taste in oxaliplatin-administered rats is due, at least in part, to increased expression of T1R2, while these alterations are reversible.

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“…Os receptores relacionados à sensação do amargo são da família T2R. A expressão de genes relacionados a esses receptores pode estar diminuída em pacientes com hipogeusia (Onoda et al, 2011).…”

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“…A redução da sensação do sabor amargo foi associada a maior perda de peso em pacientes sob quimioterapia para carcinoma pulmonar de pequenas células (Ovesen et al, 1991). A hipogeusia do sabor amargo parece estar associada a menor expressão de genes T2R, relacionados a identificação desse sabor em uma ampla gama de substâncias, incluindo toxinas bacterianas (Onoda et al, 2011). Uma das explicações para essas alterações é a ação de citocinas pró-inflamatórias nos receptores dos botões gustativos relacionados ao sabor amargo.…”

Section: Variáveis Clínicas E Despapilaçãounclassified

Análise das alterações de paladar durante o transplante de célulastronco hematopoiéticas

Ferreira¹

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Ferreira MH. Analysis of taste alterations during hematopoietic cell transplantation [dissertation]. São Paulo: Universidade de São Paulo, Faculdade de Odontologia; 2018. Versão Corrigida.Taste changes during hematopoietic cell transplantation (HCT) are often described after the end of transplantation, however little is known about which flavors and what type of perception changes are experienced by patients during transplantation. The aim of this study was to characterize the taste alterations and taste buds atrophy present in the period of neutropenia of HCT, as well as to verify if there is association between these alterations and clinical variables related to transplant and oral mucosal toxicity. The impact of taste and oral mucosal changes on patients' quality of life was also evaluated. We selected 52 patients undergoing autologous and allogenic HCT, who underwent taste acuity tests prior to conditioning and during neutropenia. Patients were also submitted to oroscopy for evaluation of oral mucositis and taste buds atrophy. An investigation was also conducted on xerostomia and taste changes. It was carried out an acuity test in the perception of sweet, bitter, sour and salty flavors, offered in solutions containing low and high concentrations of substances stimulating these flavors. Quality of life was assessed by the EORTC questionnaire QLQ-C30 and QLQ-H & N35. It was found that 46.1% of the patients exhibited taste alterations before the conditioning of the HCT, but that this frequency increased to 90.5% during neutropenia (c2 test, p = 0.042). The most common alteration was the hypogeusia of the strongest concentrations, especially bitter. High frequency of patients (72.0%) were detected with taste buds atrophy in the period of neutropenia, but this taste buds atrophy was not associated with alterations in the perception of each type of taste. There was no association between changes in taste and type of transplant, type of conditioning, and variables related to toxicity in the oral cavity and in the gastrointestinal tract. There was a significant association between taste buds atrophy and oral mucositis duration ≥8 days (OR = 5.62, 95% CI = 0.98-60.30, p = 0.039). Salivary and taste changes significantly reduced quality of life during neutropenia compared to the pre-condition period. It was concluded that taste alterations are already present before HCT, but there is an increase in the frequency of these alterations, mainly hypogeusia. The tongue taste buds atrophy occurred after conditioning, and was associated with a longer duration of oral mucositis. The impact of salivary and taste changes on patient quality of life during neutropenia is high and should be minimized through the adoption of more comprehensive strategies that include maintenance of oral mucosal integrity.

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Patients with hypogeusia show changes in expression of T2R taste receptor genes in their tongues

Abstract: Our results suggest that decreased expression of taste-associated genes may be involved in hypogeusia in humans. In addition, the evaluation of taste receptor gene expression may be useful clinically for an objective diagnosis of hypogeusia or to evaluate the severity of the disorder.

Cited by 18 publications

References 24 publications

Effects of zinc deficiency and supplementation on gene expression of bitter taste receptors (TAS2Rs) on the tongue in rats

Effects of zinc deficiency and supplementation on gene expression of bitter taste receptors (TAS2Rs) on the tongue in rats

Oxaliplatin Alters Expression of T1R2 Receptor and Sensitivity to Sweet Taste in Rats

Análise das alterações de paladar durante o transplante de célulastronco hematopoiéticas

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