Patients with Left Ventricular Thrombus Despite Normal Systolic Function

Left Ventricular Thrombus Formation in a Structurally and Functionally Normal Heart: A Case Report and Literature Review

“…1,2 In a case series of 31 patients, with a median age of 43 years and slight male predominance (58%), embolic complications made up the primary presenting conditions in about 27 (88%) patients, and febrile illness was present in only 3 patients. 3 Unlike our patient, most reported cases of LV thrombus with normal LV ejection fraction occurred secondary to medical conditions associated with greater risk of thrombosis formation, such as inflammatory conditions (rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases), blood dyscrasias (essential thrombocythemia, hyperaggregable platelets, protein C or S deficiency), or malignancies. [4][5][6] Similar to our patient, 2 case reports identified LV thrombus with no underlying cause.…”

“…Conversely, oral anticoagulation should be resumed if the thrombus persists. 11 However, as the literature has reported thrombi recurrence, individuals with normal LV systolic function and no identifiable cause require prolonged anticoagulation 3 ; we have advised our patient to take vitamin K antagonist with goal INR values of 2 to 2.5 and follow up closely to reassess the anticoagulation duration periodically.…”

“… 1 , 2 In a case series of 31 patients, with a median age of 43 years and slight male predominance (58%), embolic complications made up the primary presenting conditions in about 27 (88%) patients, and febrile illness was present in only 3 patients. 3 …”