Patients with papular urticaria have IgG antibodies to bedbug (Cimex lectularius) antigens

Abdel-Naser, Mohamed Badawy; Lotfy, Ranya Adel; Al-Sherbiny, Maged; Ali, Nematallah

doi:10.1007/s00436-005-0076-9

Cited by 34 publications

(18 citation statements)

References 20 publications

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“…Regardless of their vectorial capacity, bed bug infestations, actual or perceived, have many negative associations (Doggett et al, 2012;Goddard, 2010;Goddard and de Shazo, 2012;Hwang et al, 2005;Potter, 2005). Bed bug feeding leads to an allergic reaction that results in erythematous or papular urticaria-like dermatitis (Abdel-Naser et al, 2006;Doggett et al, 2012;Leverkus et al, 2006a;Scarupa and Economides, 2006;Stibich and Schwartz, 2001;Stucki and Ludwig, 2008). This reaction is likely due to protein components of bed bug saliva that are injected into the host during feeding (Francischetti et al, 2010;Valenzuela et al, 1996;Valenzuela et al, 1995).…”

Section: Bed Bugs and Public Healthmentioning

confidence: 90%

Mechanisms that contribute to the establishment and persistence of bed bug infestations

Benoit¹,

Attardo

2013

Terr Arthropod Rev

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Bed bugs have reestablished as pests over the last two decades after a period of near eradication throughout large portions of the world. The increasing frequency of bed bug infestations has prompted research into every facet of bed bug biology. Of particular interest is identification ofthe specific factors that allow bed bugs to be transported, to thrive within human dwellings and to survive pest control strategies. This review provides a synopsis ofthe biochemical, physiological and molecular mechanisms that contribute to the resurgence of bed bugs, with a focus upon the aspects that allow bed bugs to overcome the roadblocks preventing establishment and persistence in close proximity to humans. Topics discussed include dispersal, host avoidance, mating, chemical signaling, symbiosis, blood feeding, thermal tolerance, starvation resistance, dehydration resistance and pesticide resistance. These aspects of Cimex biology are explored within the context of the effect that these traits have upon transportation, establishment and eradication of bed bugs with an emphasis on the issues of pesticide resistance and population resurgence. In general, bed bugs are exceptional in their abihty to proliferate in close-proximity to humans. The emergence of recent adaptations such as pesticide resistance has exacerbated the already difficult task of eliminating bed bug infestations.

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Section: Bed Bugs and Public Healthmentioning

confidence: 90%

Mechanisms that contribute to the establishment and persistence of bed bug infestations

Benoit¹,

Attardo

2013

Terr Arthropod Rev

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“…Al igual que en este estudio, en otros se ha demostrado que en latitudes no tropicales se registraba una clara diferencia en la reacción de la IgE entre sanos y pacientes con hipersensibilidad (58,59). En contraste, en Egipto, otro país ubicado principalmente en el trópico, no se encontraron diferencias significativas entre el reconocimiento de la IgE de las bandas del extracto de pulga o del de mosquito (60). Según estos hallazgos, pueden existir otros factores determinantes en la patogenia de la enfermedad.…”

Section: Respuesta Humoralunclassified

Papular urticaria: A review of causal agents in Colombia

et al. 2016

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López: análisis bioinformático y datos experimentales inéditos Todos los autores contribuyeron en igual medida a la redacción del manuscrito. La urticaria papular es una enfermedad alérgica causada por la picadura de insectos, la cual predomina en el trópico. El objetivo de esta revisión fue profundizar en sus aspectos epidemiológicos e inmunológicos, particularmente con base en datos publicados en Latinoamérica. Se hizo una revisión no sistemática mediante la búsqueda electrónica de artículos sobre la epidemiología de la urticaria papular, las características entomológicas de los agentes causales y los mecanismos inmunológicos asociados. Según los diversos reportes de centros médicos de Latinoamérica la urticaria papular es frecuente; el único estudio de prevalencia publicado indica que afecta a una cuarta parte de los niños escolares de Bogotá. Hay información sobre la relación causal entre la exposición domiciliaria a la pulga, la pobreza y la urticaria papular en Bogotá, una ciudad representativa de las altitudes andinas. No hay estudios que indaguen directamente sobre los insectos causales en zonas cálidas, aunque se sospecha clínicamente de los mosquitos Aedes aegypti y Culex quinquefasciatus. En cuanto a su patogenia, se destaca la participación de mecanismos celulares que involucran las células colaboradoras Th2, lo cual explica que sea una condición de hipersensibilidad retardada. El papel de la inmunoglobulina E (IgE) en la urticaria papular no está tan claro. Se desconocen los antígenos derivados de los insectos que causan la enfermedad, aunque se plantea que existen moléculas comunes de reacción cruzada entre los insectos, tales como el alérgeno Cte f 2 en la pulga, y sus homólogos en los mosquitos. La urticaria papular es una condición frecuente en Latinoamérica que debe investigarse en profundidad. La caracterización inmunológica de los componentes moleculares que causan esta condición puede resolver interrogantes sobre su etiología y su patogenia. Urticaria papular y sus agentes causales en ColombiaPalabras clave: urticaria; insectos; Aedes; Culex; Ctenocephalides; hipersensibilidad. doi: http://dx.doi.org/10.7705/biomedica.v36i4.3258 Papular urticaria: A review of causal agents in ColombiaPapular urticaria is a chronic allergic reaction induced by insect bites, which is common in the tropics. The objective of this review was to deepen on epidemiological and immunological aspects of this disease, focused on data published in Latin American countries. We conducted a non-systematic review of the literature through electronic search on the epidemiology of papular urticaria, the entomological characteristics of the causative agents and associated immunological mechanisms. Several reports from medical centers suggest that papular urticaria is common in Latin America. Only one epidemiological survey designed to estimate prevalence of papular urticaria has been published, reporting that about a quarter of children under six years of age is affected by this condition in Bogotá. There is evidence on the ca...

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“…The absence of an antibody response against saliva from mosquitoes or Culicoides midges in the sera of children [176] or horses [177] living in Iceland (a country exempt from these two biting arthropods) and the appearance of an IgG antibody responses in animals or humans following exposure to haematophagous arthropod bites [144,177-179] are strong arguments suggesting that the acquisition of an antibody response against haematophagous arthropod saliva is exposure dependent.…”

Section: Salivary Proteins and Host Antibody Response: Immunological mentioning

confidence: 99%

Implication of haematophagous arthropod salivary proteins in host-vector interactions

et al. 2011

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The saliva of haematophagous arthropods contains an array of anti-haemostatic, anti-inflammatory and immunomodulatory molecules that contribute to the success of the blood meal. The saliva of haematophagous arthropods is also involved in the transmission and the establishment of pathogens in the host and in allergic responses. This survey provides a comprehensive overview of the pharmacological activity and immunogenic properties of the main salivary proteins characterised in various haematophagous arthropod species. The potential biological and epidemiological applications of these immunogenic salivary molecules will be discussed with an emphasis on their use as biomarkers of exposure to haematophagous arthropod bites or vaccine candidates that are liable to improve host protection against vector-borne diseases.

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Patients with papular urticaria have IgG antibodies to bedbug (Cimex lectularius) antigens

Cited by 34 publications

References 20 publications

Mechanisms that contribute to the establishment and persistence of bed bug infestations

Mechanisms that contribute to the establishment and persistence of bed bug infestations

Papular urticaria: A review of causal agents in Colombia

Implication of haematophagous arthropod salivary proteins in host-vector interactions

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