Patients With Parkinson’s Disease Have Poorer Function and More Flexion Contractures After Total Knee Arthroplasty

Goh, Graham S.; Zeng, Gerald Joseph; Tay, Darren Keng Jin; Lo, Ngai-Nung; Yeo, Seng-Jin; Liow, Ming Han Lincoln

doi:10.1016/j.arth.2020.11.016

Cited by 13 publications

(16 citation statements)

References 31 publications

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“…Goh et al have claimed that although patients with PD have relatively poorer knee function and QoL, they experience functional gains, and high satisfaction is achieved ( 14 ). In a comparative level 3 evidence study published in 2021, the rates of complications, mortality, and revision, as well as patient-reported outcomes and the satisfaction of patients with PD, were compared with those of a control group after unilateral primary TKA implantation ( 14 ). Patients with PD who underwent TKA were identified and matched 1:1 with a control group using propensity scores adjusting for age, sex, BMI, Charlson comorbidity index (CCI), baseline ROM, KSS, KSFS, Oxford Knee Score (OKS), and 36-item SF-12 MCS and PCS.…”

Section: The Impact Of Pd On Results Of Primary Tkamentioning

confidence: 99%

“…Although the patients with PD had relatively poorer knee function and QoL than in the control group, these patients experienced significant functional gains compared with their preoperative status. In addition, their satisfaction with the outcome of TKA was high ( 14 ).…”

Section: The Impact Of Pd On Results Of Primary Tkamentioning

confidence: 99%

“…The study of Kleiner et al demonstrated that the complication rate was not higher in patients with PD, suggesting that this group could be safely considered for TKA ( 17 ). The overall complication rate reported by Goh et al was 26.3% in the PD group and 10.5% in the control group ( P = 0.030) ( 14 ).…”

Section: Postoperative Complications Of Primary Tka In Patients With Pdmentioning

confidence: 92%

“…Although a direct comparison of mortality between studies is difficult to perform due to differences in demographics, such as age, sex, medical comorbidity, and ethnic differences, Rondon et al concluded in 2018 that mortality after TKA in patients with PD was higher than that of the general population ( 20 ). Goh et al found that the all-cause mortality was higher in the PD group (15.8% vs 5.3%, P = 0.067) ( 14 ). According to Baek et al ., the cumulative mortality rates in the PD group and in the control group were 31% (9/29) and 6.9% (4/58) ( P < 0.05), respectively, at the final follow-up ( 18 ).…”

Section: Mortality After Tka In Patients With Pdmentioning

confidence: 99%

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The impact of Parkinson’s disease on results of primary total knee arthroplasty

Rodríguez-Merchán

Kalbakdij-Sánchez²

2022

EFORT Open Reviews

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Parkinson’s disease (PD) is a common neurodegenerative disorder. When patients with PD undergo total knee arthroplasty (TKA) for knee osteoarthritis, poorer knee function and poorer quality of life are obtained than in matched cohorts (MCs). However, the degree of patient satisfaction is usually high. The mean length of stay is 6.5% longer in patients with PD than in MCs. Compared with MCs, patients with PD undergoing TKA have a 44% higher risk of complications. In patients with PD, the overall complication rate is 26.3% compared with 10.5% in MCs; the periprosthetic joint infection rate is 6.5% in patients with PD vs 1.7% in MCs; and the periprosthetic fracture rate is 2.1% in patients with PD vs 1.7% in MCs. The 90-day readmission rate is 16.29% in patients with PD vs 12.66% in MCs. More flexion contractures occur in patients with PD. The rate of medical complications is 4.21% in patients with PD vs 1.24% in MCs, and the rate of implant-related complications is 5.09% in patients with PD vs 3.15% in MCs. At 5.3 years’ mean follow-up, the need for revision surgery is 23.6%. The 10-year implant survival, taking revision of any of the components as an endpoint, is 89.7% in patients with PD vs 98.3% in MCs.

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Section: The Impact Of Pd On Results Of Primary Tkamentioning

confidence: 99%

Section: The Impact Of Pd On Results Of Primary Tkamentioning

confidence: 99%

Section: Postoperative Complications Of Primary Tka In Patients With Pdmentioning

confidence: 92%

Section: Mortality After Tka In Patients With Pdmentioning

confidence: 99%

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The impact of Parkinson’s disease on results of primary total knee arthroplasty

Rodríguez-Merchán

Kalbakdij-Sánchez²

2022

EFORT Open Reviews

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“…For example, the decrease of protein solubility may lead to the formation of insoluble aggregates. These aggregates may give rise to varieties of neurodegenerative diseases [4] , such as Alzheimer's Disease, Amyotrophic Lateral Sclerosis and Parkinson's Disease, which have a serious effect on human cognitive functions and behavior [5][6][7] . In addition, the sickness rate of cataract may be increased markedly along with the added number of insoluble proteins in the lens [8] .…”

Section: Introductionmentioning

confidence: 99%

Research on protein solubility prediction based on ensemble learning and feature fusion

2022

AJCIS

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Protein solubility is one of the momentous properties of a protein that can effectively participate in and inhibit the physiological and biochemical processes of cancer cells in the human body. Therefore, understanding the solubility of proteins may be significant to find the mechanism of diseases caused by the solubility of proteins. In this paper, to improve the protein solubility prediction performance and address the inadequacy of existing protein solubility prediction methods that more feature information about protein sequences is difficult to be obtained. A protein solubility prediction model named EL-FFsol is proposed, which is based on the CatBoost ensemble learning framework and multiple feature fusion of protein sequences. First of all, protein sequence features were introduced to build fusion representation, including the Physicochemical Properties, One-hot Feature Encoding, Amino Acid Composition and Statistical Features. Additionally, the CatBoost was employed to construct an ensemble learning model to predict protein solubility. Finally, EL-FFsol was tested on the benchmark dataset to predict the solubility of proteins. In terms of accuracy, matthews correlation coefficient, sensitivity, specificity, area under ROC curve and area under P-R curve, 0.5480, 0.6630, 0.8729, 0.8540 and 0.8440 performances. Compared with the DeepSOL and DDcCNN, the matthews correlation coefficient was increased by 1.68% and 0.79%, the area under ROC curve was increased by 1.60% and 2.20% and the area under P-R curve was increased by 1.70% and 2.40%, respectively.

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Considerations for Arthroplasty in Secondary Arthritis: Sickle Cell Disease, Paget’s Disease, Parkinson’s Disease, Post-traumatic Arthritis, Previous Septic Arthritis, and Chronic Neurological Disorders

Tandogan,

Kayaalp

2024

Fast Track Surgery in Hip and Knee Arthroplasty

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Patients With Parkinson’s Disease Have Poorer Function and More Flexion Contractures After Total Knee Arthroplasty

Cited by 13 publications

References 31 publications

The impact of Parkinson’s disease on results of primary total knee arthroplasty

The impact of Parkinson’s disease on results of primary total knee arthroplasty

Research on protein solubility prediction based on ensemble learning and feature fusion

Considerations for Arthroplasty in Secondary Arthritis: Sickle Cell Disease, Paget’s Disease, Parkinson’s Disease, Post-traumatic Arthritis, Previous Septic Arthritis, and Chronic Neurological Disorders

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