Patients with periodontitis and erectile dysfunction suffer a greater incidence of major adverse cardiovascular events: A prospective study in a Spanish population

Mesa, Francisco; Arrabal-Polo, Miguel Ángel; Magán‐Fernández, Antonio; Arrabal, Miguel; Martín, Amada; Muñoz, Ricardo; Rodríguez-Agurto, Alejandro; Bravo, Manuel

doi:10.1002/jper.21-0477

Cited by 5 publications

(3 citation statements)

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“…Based on prior investigations, erectile dysfunction is thought to be an early indicator of endothelial impairment. This also implies that its pathophysiological pathways may overlap with those involved in the development of certain cardiovascular diseases and that the presence of erectile dysfunction may raise the chance of developing cardiovascular diseases [20][21][22][23]. Therefore, a unified view of cardiovascular disease and erectile dysfunction helps us to better understand erectile dysfunction.…”

Section: Plos Onementioning

confidence: 99%

Dietary calcium, phosphorus, and potassium intake associated with erectile dysfunction in the National Health and Nutrition Examination Survey (NHANES) 2001 to 2004

Deng,

Ke,

Guo

2024

PLoS ONE

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Background Erectile dysfunction is now a common disorder of sexual function, and its relationship to dietary calcium, phosphorus, and potassium has not been well studied. We set out to determine if dietary intakes of calcium, phosphorus, and potassium are related to erectile dysfunction in U.S. men. Methods For this cross-sectional investigation, we used data from NHANES 2001–2004. To investigate the connection of dietary calcium, phosphorus, and potassium intake with erectile dysfunction, we employed multivariate logistic regression, smoothed curve fitting, and subgroup analysis. Results This cross-sectional study comprised 3,556 eligible male subjects in total, with a weighted mean age of 49.93±18.13 years. After controlling for race and age, the greatest tertile of calcium consumption was found to have a 34% lower risk of erectile dysfunction than the lowest tertile (OR = 0.66; 95% CI = 0.52–0.84; p = 0.0006). The risk of erectile dysfunction was found to be reduced by 33% (OR = 0.67; 95% CI = 0.52–0.87; p = 0.0024) for the highest tertile of phosphorus intake compared to the lowest tertile of phosphorus intake and by 35% (OR = 0.65; 95% CI = 0.50–0.83; p = 0.0006) for the highest tertile of potassium intake compared to the lowest tertile of potassium intake in the fully adjusted model. Conclusion Erectile dysfunction and dietary consumption of calcium, phosphorus, and potassium are inversely associated with the U.S. population. To confirm the accuracy of our findings, additional prospective studies are necessary. Furthermore, it is imperative to do further fundamental research at the molecular level to gain a deeper understanding of the underlying mechanisms.

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Section: Plos Onementioning

confidence: 99%

Dietary calcium, phosphorus, and potassium intake associated with erectile dysfunction in the National Health and Nutrition Examination Survey (NHANES) 2001 to 2004

Deng,

Ke,

Guo

2024

PLoS ONE

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“…Recently, a study evaluated the prevalence of periodontitis in patients with ED, observing that patients with ED showed a greater extent of moderate or severe chronic periodontitis than the control group [ 147 ]. A prospective study, also conducted by the same research group, observed that patients with periodontitis and ED showed a 3.7-fold increased risk of suffering major cardiovascular adverse events after a mean follow-up of 4.2 years [ 148 ]. In conclusion, the literature review suggests that preventive actions against periodontal disease in both men and women are justified in order to avoid problems such as infertility and preterm birth.…”

Section: Periodontal Health and Disease Infertility And Adverse Pregn...mentioning

confidence: 99%

Periodontal Health and Disease in the Context of Systemic Diseases

Isola

Santonocito

Lupi

et al. 2023

Mediators of Inflammation

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During recent years, considerable progress has been made in understanding the etiopathogenesis of periodontitis in its various forms and their interactions with the host. Furthermore, a number of reports have highlighted the importance of oral health and disease in systemic conditions, especially cardiovascular diseases and diabetes. In this regard, research has attempted to explain the role of periodontitis in promoting alteration in distant sites and organs. Recently, DNA sequencing studies have revealed how oral infections can occur in distant sites such as the colon, reproductive tissues, metabolic diseases, and atheromas. The objective of this review is to describe and update the emerging evidence and knowledge regarding the association between periodontitis and systemic disease and to analyse the evidence that has reported periodontitis as a risk factor for the development of various forms of systemic diseases in order to provide a better understanding of the possible shared etiopathogenetic pathways between periodontitis and the different forms of systemic diseases.

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“…However, a higher risk of heart disease (RR: 2.58, 95% CI: 2.20–.03) and cerebrovascular diseases (RR: 3.11, 95% CI: 2.42–3.98) were detected ( 126 ). Likewise, patients with periodontitis and erectile dysfunction presented a higher number of cardiovascular adverse events adjusted by age and previous cardiovascular disease ( 127 ).…”

Section: Association Of Periodontitis With Cvdsmentioning

confidence: 99%

Oral microbiome mediated inflammation, a potential inductor of vascular diseases: a comprehensive review

Gualtero,

Lafaurie,

Buitrago

et al. 2023

Front. Cardiovasc. Med.

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The dysbiosis of the oral microbiome and vascular translocation of the periodontopathic microorganism to peripheral blood can cause local and systemic extra-oral inflammation. Microorganisms associated with the subgingival biofilm are readily translocated to the peripheral circulation, generating bacteremia and endotoxemia, increasing the inflammation in the vascular endothelium and resulting in endothelial dysfunction. This review aimed to demonstrate how the dysbiosis of the oral microbiome and the translocation of oral pathogen-induced inflammation to peripheral blood may be linked to cardiovascular diseases (CVDs). The dysbiosis of the oral microbiome can regulate blood pressure and activate endothelial dysfunction. Similarly, the passage of periodontal microorganisms into the peripheral circulation and their virulence factors have been associated with a vascular compartment with a great capacity to activate endothelial cells, monocytes, macrophages, and plaquettes and increase interleukin and chemokine secretion, as well as oxidative stress. This inflammatory process is related to atherosclerosis, hypertension, thrombosis, and stroke. Therefore, oral diseases could be involved in CVDs via inflammation. The preclinic and clinical evidence suggests that periodontal disease increases the proinflammatory markers associated with endothelial dysfunction. Likewise, the evidence from clinical studies of periodontal treatment in the long term evidenced the reduction of these markers and improved overall health in patients with CVDs.

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Patients with periodontitis and erectile dysfunction suffer a greater incidence of major adverse cardiovascular events: A prospective study in a Spanish population

Cited by 5 publications

References 50 publications

Dietary calcium, phosphorus, and potassium intake associated with erectile dysfunction in the National Health and Nutrition Examination Survey (NHANES) 2001 to 2004

Dietary calcium, phosphorus, and potassium intake associated with erectile dysfunction in the National Health and Nutrition Examination Survey (NHANES) 2001 to 2004

Periodontal Health and Disease in the Context of Systemic Diseases

Oral microbiome mediated inflammation, a potential inductor of vascular diseases: a comprehensive review

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