Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database

Mehta, Nehal N.; Azfar, Rahat S.; Shin, Daniel B.; Neimann, Andrea L.; Troxel, Andrea B.; Gelfand, Joel M.

doi:10.1093/eurheartj/ehp567

Cited by 608 publications

(589 citation statements)

References 45 publications

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“…Psoriasis is a common cutaneous inflammatory disorder in which the dermal microvasculature undergoes distinctive changes, including HEV formation, which facilitates trafficking of lymphocytes to the skin (253). There is an interesting correlation between Ang II-mediated activation of the immune system and hypertension (158,450) with the increased risk of hypertension and cardiovascular mortality in psoriasis patients that is associated with elevated levels of Ang II (253,285).…”

Section: High Endothelial Venulesmentioning

confidence: 99%

Reactive Oxygen Species in Inflammation and Tissue Injury

Mittal

Siddiqui

Tran

et al. 2014

Antioxidants & Redox Signaling

3,606

2,424

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Reactive oxygen species (ROS) are key signaling molecules that play an important role in the progression of inflammatory disorders. An enhanced ROS generation by polymorphonuclear neutrophils (PMNs) at the site of inflammation causes endothelial dysfunction and tissue injury. The vascular endothelium plays an important role in passage of macromolecules and inflammatory cells from the blood to tissue. Under the inflammatory conditions, oxidative stress produced by PMNs leads to the opening of inter-endothelial junctions and promotes the migration of inflammatory cells across the endothelial barrier. The migrated inflammatory cells not only help in the clearance of pathogens and foreign particles but also lead to tissue injury. The current review compiles the past and current research in the area of inflammation with particular emphasis on oxidative stress-mediated signaling mechanisms that are involved in inflammation and tissue injury. Antioxid. Redox Signal. 20, 1126-1167.

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Section: High Endothelial Venulesmentioning

confidence: 99%

Reactive Oxygen Species in Inflammation and Tissue Injury

Mittal

Siddiqui

Tran

et al. 2014

Antioxidants & Redox Signaling

3,606

2,424

View full text Add to dashboard Cite

show abstract

“…Psoriasis is an independent risk factor for MI, particularly in young patients with a severe form of the disease. Dyslipidaemia is correlated with an increased mortality from MI and stroke [58]. Epicardial fat tissue (EFT) plays an important role in CVD development via proinflammatory cytokines and adipokines which are synthesized in that tissue.…”

Section: Comorbidities Of Psoriasis Cardiovascular Diseasesmentioning

confidence: 99%

“…Consequently, it is possible to reduce the dosage of systemic therapy used thus far or terminate treatment altogether in over 20% of patients [65,66]. Dyslipidemia koreluje ze zwiększoną śmiertelnością z powodu MI i udaru [58]. Osierdziowa tkanka tłusz-czowa (epicardial fat tissue -EFT) odgrywa ważną rolę w rozwoju CVD poprzez syntetyzowane w niej cytokiny prozapalne i adipokiny.…”

Section: Obesityunclassified

The role of lipids in psoriasis

Baran¹,

Kiluk²,

Myśliwiec³

et al. 2017

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Psoriasis, affecting 2-4% of the world's population, is a chronic recurrent inflammatory skin disease. Its multifactorial aetiopathogenesis consists of, for example, abnormal epidermal proliferation, immune disturbances, and genetic, psychosomatic, environmental and hormonal factors. Psoriasis is also considered to be a systemic disorder closely associated with cardiovascular diseases, atherosclerosis, diabetes mellitus, obesity or metabolic syndrome. Lipids have a variety of biological functions. They participate not only in energy storage and expenditure or the formation of cell membranes, but also in inflammatory and metabolic signalling pathways. Disturbances in their homeostasis lead to the development of immunometabolic disorders, including psoriasis. Based on the available literature, this article presents selected molecular and clinical aspects involved in the multidirectional effect of lipids on psoriasis.streszczenie Łuszczyca, która występuje u 2-4% populacji na świecie, jest przewlekłą i nawrotową chorobą zapalną skóry. Na jej wieloczynnikową etiopatogenezę składają się m.in. nieprawidłowa proliferacja naskórka, zaburzenia immunologiczne, czynniki genetyczne, psychosomatyczne, środowiskowe i hormonalne. Łuszczyca jest również uznawana za schorzenie ogólnoustrojowe, związane z chorobami układu sercowo--naczyniowego, miażdżycą, cukrzycą, otyłością i zespołem metabolicznym. Lipidy pełnią wiele biologicznych funkcji, biorą udział nie tylko w magazynowaniu i wydatkowaniu energii, tworzeniu błon komórko-wych, lecz także w zapalnych i metabolicznych szlakach sygnałowych. Zaburzenia ich homeostazy powodują rozwój schorzeń immunometabolicznych, w tym łuszczycy. W niniejszej pracy przedstawiono na podstawie dostępnego piśmiennictwa wybrane aspekty molekularne i kliniczne wielokierunkowego wpływu lipidów na łuszczycę.

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“…Риск инфаркта миокарда, ассоциирован-ный с наличием псориаза, наиболее высокий у молодых пациентов с выраженным псориазом, уменьшается с воз-растом и остается повышенным даже после контроля традиционных сердечно-сосудистых факторов риска . Пациенты с тяжелым течением псориаза имеют выше риск инфаркта миокарда, чем у пациентов с мягким тече-нием псориаза, что подтверждает гипотезу, что более выраженная иммунная активность ассоциируется с более высоким риском инфаркта миокарда и сердечно-сосуди-стой смерти [185,186] .…”

Section: псориазunclassified