Patients with tuberculosis in Bolivia: why do they die?

Ollé-Goig, Jaime E

doi:10.1590/s1020-49892000000800001

Cited by 11 publications

(5 citation statements)

References 15 publications

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“…16 A close examination of the characteristics of patients progressing to death revealed that mortality rates by gender and age groups found in the present study were corroborated in the literature. 14,17,20 Higher TB risk seen among the elderly was probably due their lower immunity, more diffi cult diagnosis of TB as well as to the fact that older cohorts were more exposed to infection in the past.…”

Section: Discussionsupporting

confidence: 88%

Perfil de pacientes que evoluem para óbito por tuberculose no município de São Paulo, 2002

et al. 2008

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RESULTS:Of all tuberculosis deaths identifi ed, 78% had pulmonary form. Tuberculosis diagnosis was made after death in 30% and in primary health care units in 14%. Of them, 44% had not started treatment; 49% were not notifi ed; and 76% were men. The median age was 51 years; 52% had up to four years of schooling; 4% were probably living in the streets. Mortality rate increased with age; it was 5.0/100,000 for the entire city, ranging between zero to 35 according to the district. Previous treatment was reported for 82 out of 232 patients, and of them, 41 defaulted treatment. Diabetes (16%), chronic obstructive pulmonary disease (19%), HIV infection (11%), smoking (71%), and alcohol abuse (64%) were also reported. CONCLUSIONS:Adult males over 50, migrants and living in lower Human Development Index districts were more likely to die of tuberculosis. Low schooling and comorbidities are relevant characteristics. Low involvement of primary care units in tuberculosis diagnosis and high underreporting of cases were also seen.

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Section: Discussionsupporting

confidence: 88%

Perfil de pacientes que evoluem para óbito por tuberculose no município de São Paulo, 2002

et al. 2008

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“…Of the 443 patients who were started on therapy, 16 died before completing therapy. This frequency (3.6%) compares favorably to that reported in other studies (4% in the Gambia [25], 15% in Bolivia [26], 25% in Malawi [27], and 28% in India [28]). However, in contrast to previous reports, we had a median of 833 days of follow-up after the completion of therapy, during which 21 additional patients (4.6%) died of TB, comparable with reports from the 1960s and 1970s (29).…”

Section: Discussionsupporting

confidence: 80%

Tuberculosis-Related Deaths within a Well-Functioning DOTS Control Program

García-García

Ponce-de-León

García-Sancho

et al. 2002

Emerg. Infect. Dis.

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To describe the molecular epidemiology of tuberculosis (TB)-related deaths in a well-managed program in a low-HIV area, we analyzed data from a cohort of 454 pulmonary TB patients recruited between March 1995 and October 2000 in southern Mexico. Patients who were sputum acid-fast bacillus smear positive underwent clinical and mycobacteriologic evaluation (isolation, identification, drug-susceptibility testing, and IS6110-based genotyping and spoligotyping) and received treatment from the local directly observed treatment strategy (DOTS) program. After an average of 2.3 years of follow-up, death was higher for clustered cases (28.6 vs. 7%, p=0.01). Cox analysis revealed that TB-related mortality hazard ratios included treatment default (8.9), multidrug resistance (5.7), recently transmitted TB (4.1), weight loss (3.9), and having less than 6 years of formal education (2). In this community, TB is associated with high mortality rates.

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“…As causas presumíveis sugeridas no presente trabalho concordam com outros estudos 28,29,30,31 que classificaram como óbito por TB aqueles com causa básica descritas como hemoptise; TB pulmonar progressiva sem insuficiência respiratória; TB meníngea; insuficiência respiratória sem outro motivo para tal; morte devido à resistência às medicações; efeitos adversos à medicação antiTB; uma combinação de infecção generalizada (sepse) com anemia, caquexia e morte súbita; embolia pulmonar; pneumonia; cor pulmonar.…”

Section: Discussionunclassified

Do que morrem os pacientes com tuberculose: causas múltiplas de morte de uma coorte de casos notificados e uma proposta de investigação de causas presumíveis

et al. 2015

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O objetivo deste trabalho foi analisar as causas múltiplas de morte de uma coorte de pacientes notificados com tuberculose (TB) e apresentar uma proposta de investigação de causas presumíveis. Realizou-se linkage probabilístico entre o Sistema de Informação de Agravos de Notificação (SINAN) 2006 e o Sistema de Informação sobre Mortalidade (SIM), 2006-2008. Ocorreram 825 mortes, das quais 23% por TB, 16% com TB e 61% sem menção da TB. Duzentos e quinze (42,7%) óbitos ocorreram antes do término do esquema básico de tratamento e não tinham menção da TB, cujo perfil foi distinto do padrão quando a TB era uma das causas associadas. A elevada frequência de doenças do aparelho respiratório, AIDS e causas mal definidas sugerem falha na qualidade da informação. Elaborou-se proposta de correção das causas associadas no SIM e de investigação de óbito com base na relação de causas presumíveis. De acordo com a proposta, 26 óbitos poderiam ter a causa básica modificada. Este estudo destaca a gravidade do quadro da TB e a importância do linkage para a vigilância da TB e melhoria das informações do SIM e do SINAN.

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Patients with tuberculosis in Bolivia: why do they die?

Cited by 11 publications

References 15 publications

Perfil de pacientes que evoluem para óbito por tuberculose no município de São Paulo, 2002

Perfil de pacientes que evoluem para óbito por tuberculose no município de São Paulo, 2002

Tuberculosis-Related Deaths within a Well-Functioning DOTS Control Program

Do que morrem os pacientes com tuberculose: causas múltiplas de morte de uma coorte de casos notificados e uma proposta de investigação de causas presumíveis

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