2020
DOI: 10.1016/j.cell.2020.08.020
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Patrolling Alveolar Macrophages Conceal Bacteria from the Immune System to Maintain Homeostasis

Abstract: Highlights d AMs patrol and clean the alveolar spaces d AMs have directed movement toward inhaled bacteria d AM migration is crucial for bacterial clearance d AM migration is impaired during viral infection

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Cited by 220 publications
(190 citation statements)
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References 82 publications
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“…In uninfected PCLS, we observed generally one AMP for 2-3 alveoli (Fig S4, in good correlation with Neupane et al, [38]). After Mb infection, we observed several AMPs inside the same alveolus in 50% cases.…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…In uninfected PCLS, we observed generally one AMP for 2-3 alveoli (Fig S4, in good correlation with Neupane et al, [38]). After Mb infection, we observed several AMPs inside the same alveolus in 50% cases.…”
Section: Discussionsupporting
confidence: 90%
“…After infection with mycobacteria, ciliary activity of bronchial cells was maintained. AMP main function is to patroll the lung, crawling in and between alveoli, they sensed, chemotaxed, and phagocytosed debris or inhaled bacterial [38]. We observed increased numbers of AMPs in alveoli where Mb was present, indicating AMP mobility inside the tissue.…”
Section: Discussionmentioning
confidence: 67%
“…Over the last two decades, 2P-IVM studies have helped characterize the spatiotemporal dynamics of immune responses to viral, bacterial and parasitic infections, and uncovered unique in vivo behaviors such as pathogen dissemination by phagocytes (17,18), swarming responses by neutrophils to injurious insults (19)(20)(21), and bacterial reservoirs following infection (22). More recently, immune homeostasis functions of tissue-resident macrophages have been brought to light, such as their ability to rapidly sequester dead cells in the liver (23) and phagocytose inhaled bacteria in the lungs (24) in order to shield them from neutrophils and prevent further recruitment and tissue inflammation. While much focus has been placed on viral and bacterial infections, 2P-IVM studies on parasitic infections in vivo have been comparatively sparse.…”
Section: Two-photon Intravital Microscopy (2p-ivm): the Gold Standardmentioning
confidence: 99%
“…Alveolar MΦ play a central role in the immediate postnatal protection of the lung from infections. Importantly, alveolar MΦ exhibit a unique territorial behavior with on average three alveoli being surveilled by one AM ( Neupane et al, 2020 ). The cues for guiding alveolar MΦ function and distribution in an organ that undergoes a fourfold increase in weight in the first three weeks of life (in mice) are only partially understood.…”
Section: Introductionmentioning
confidence: 99%