Patrón miliar en paciente con infección por el virus de la inmunodeficiencia humana y tratamiento tuberculostático

Cuadrado, J. del Pino; Casero, Miguel Ángel Racionero; Tejederas, J. R. Artacho; Avilés, J Colomina

doi:10.1016/s0014-2565(01)70799-0

Cited by 2 publications

(1 citation statement)

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“…The sole form of TB-related IRS observed in our study was lymph node enlargement, which was previously reported by other authors [14,15], although many of them also observed transient worsening of pulmonary infiltrates, pleural effusions, or miliary infiltrates [13,[16][17][18], which we did not detect.…”

Section: Discussionsupporting

confidence: 64%

Immune reconstitution syndrome in patients treated for HIV and tuberculosis in Rio de Janeiro

Serra¹,

Hadad²,

Orofino³

et al. 2007

Braz J Infect Dis

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examine cases of immune reconstitution syndrome (IRS) and its incidence rate in tuberculosis (TB)-human immunodeficiency virus (HIV) coinfected patients. The incidence rate (IR) was calculated using a Poisson regression. The confidence interval (CI) that was stipulated was 95%. IRS occurred in 10/84 HIV and TB-positive patients; nine of them were on highly active anti-retroviral therapy (HAART) during a mean of 61.7 (±59) days following the introduction of antiretrovirals. Lymph-node enlargement was the sole clinical manifestation. CD4 counts were <100 cells/mm 3 in 50% of the patients, at the time of TB diagnosis. All but two patients were treated with prednisone, and recovered from TB within a mean of 91 days (±30 days). One relapse of TB was observed, but there were no IRS-related deaths. The incidence rate was higher (IR=11.18; CI, 1.41-88.76) in patients that had superficial lymph node enlargement at the moment of TB diagnosis (not associated with TB), extrapulmonary TB (IR=1.97; CI, 0.44-8.79), were antiretroviral naive (IR=1.85; CI, 0.48-7.16), and CD4 counts <100 cells/mm 3 (IR=1.50; CI, 0.40-5.59), although with a wide CI. IRS was frequent in our sample, occurred more frequently in HIV-naive patients with lymph-node enlargement and extrapulmonary TB. No cases of new pulmonary lesions or worsening of pulmonary infiltrates were observed.

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