Pattern and interpretation of hepatitis B virus markers among pregnant women in North East Egypt

Kishk, Rania; Mandour, Mohamed; Elprince, Mohamed; Salem, Amany A.; Nemr, Nader; Eida, Mohammed; Ragheb, Mostafa

doi:10.1007/s42770-019-00174-3

Cited by 19 publications

(20 citation statements)

References 28 publications

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“…This nding is in line with the WHO intermediate classi cation of HBsAg prevalence, which is 2-7% [23]. Moreover, it is similar to other studies conducted previously in Bahir Dar 4.4%, Arba Minch 4.3%, Dessie 4.9%, and Egypt 5%, South Africa 4.5% [17,[24][25][26][27].…”

Section: Discussionsupporting

confidence: 90%

Hepatitis B and C viruses’ infection and associated factors among pregnant women in the Amhara region, Ethiopia: implications for prevention of vertical transmission.

Dagnew¹,

Million²,

Gizachew³

et al. 2020

Preprint

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Background Hepatitis virus infection is a major public health burden and silent killer disease in sub-Saharan Africa, including Ethiopia. Despite the recommendations of the World Health Organization, screening for hepatitis B virus (HBV) and hepatitis C virus (HCV) in pregnant women is not done routinely in public health institutions. Therefore, this study aimed to determine the burden of HBV and HCV and its associated factors among pregnant women in the Amhara region, Ethiopia. Methods A total of 1121 pregnant women were enrolled in the study. Data on sociodemographic and associated factors were collected using a structured questionnaire. Blood was collected from the pregnant women, and serum samples were tested for HBsAg and anti-hepatitis C virus antibody (anti-HCV) using ELISA. The status of HIV-infected pregnant women was collected from the records of their charts. SPSS version 20 was used for data analysis, and a binary logistic regression model was used to assess the relationship between factors associated with HBV and HCV infection. Results The seroprevalence of HBsAg and anti-HCV antibody were 4.6% and 1.6, respectively. The co-infection rate of HBV/HCV was 1.4% (1/69). Ten out of 52 HBV positive cases (19.2%) were co-infected with HIV. Only 20 (1.8%) pregnant women had the HBV vaccine. Interestingly, pregnant women with a history of multiple sexual partners (AOR = 3.2,95% CI,1.7–7.6), blood transfusion (AOR = 7.6,95% CI,2.9–16.9), family history of HBV (AOR = 3.5, 95% CI,1.7–7.6), being HIV-positive (AOR = 2.5, 95% CI,1-5.9), and tattooing (AOR = 2, 95% CI, 1-3.8) were significant predictors of HBV infection. Conclusions HBV and HCV infections were intermediate among pregnant women; risk factors were responsible for the majority of cases. Infants born from these infected mothers are at risk of infection. This calls for integration of HBV prevention into the PMTC of HIV. Thus, the provision of health education on HBV and HCV transmission, vaccination, and screening of all pregnant women routinely is essential for PMTCT.

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Section: Discussionsupporting

confidence: 90%

Hepatitis B and C viruses’ infection and associated factors among pregnant women in the Amhara region, Ethiopia: implications for prevention of vertical transmission.

Dagnew¹,

Million²,

Gizachew³

et al. 2020

Preprint

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show abstract

“…In the immune group following infection (30.3%), it is not exactly known when this infection had occurred. Infection after successful vaccination has been reported and usually results in reactivity to HBcAb and boosting the titer of HBsAb [45]. The e cacy of hepatitis B vaccination of HD patients in this study who were negative to HBcAb (62%) is comparable to 69% reported in a large meta-analysis study [46].…”

Section: Discussionsupporting

confidence: 67%

Liver Morbidity in Patients Negative for Overt HBV and HCV Undergoing Maintenance Hemodialysis: a Hospital-based Study

Alduraywish

Kishk

Omar

et al. 2020

Preprint

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Background: End-stage renal disease (ESRD) is an increasing health problem worldwide. Older age, diabetes and hypertension, acute kidney damage are among some of the factors that play a role in ESRD. This study aims at exploring liver morbidity (LM) among hemodialysis (HD) patients in an endemic country. Methods: The study included 142 patients aged 12 to 75 years; 53.5% were males. Data were retrieved from files and all participants were examined by abdominal ultrasonography and tested for liver functions and markers and viremia of HCV and HBV. Results: Three patterns of LM were found in 62 (43.7%); fatty in 30, fibrous in 19 and hepatitis in 13. The duration of renal impairment (p=0.02), duration of hemodialysis (p=0.011), and total dialysis sessions (p=0.007) were associated with LM. ALT and AST >40 IU/L levels were elevated in 9.9% and 9.2% of patients. All 14 patients with high ALT showed evidence of LM (p=0.017) compared to 4 of 13 patients with elevated AST (p<0.001). The ROC curve revealed ALT and AST cut-off points of 16.5 and 25.5 IU/L to discriminate LM. According to the new values, 58.5% and 40.1% of the studied participants had high ALT and AST. Conclusion: LM is common among EDKD patients undergoing hemodialysis despite the limited role of ALT and AST. The use of ultrasonography and the new lower levels of ALT and AST could improve the screening approach of LM.

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“…This study detected (82.4%) HBeAg negative and 33(17.6%) HBeAg positive [41]. However; in studies in Ismailia and Benha, all cases were HBeAg negative and HBeAb positive [20,21]. Reduction of HBeAg positivity in HBV infected ones in Egypt might be attributed to improve vaccination coverage [42].…”

Section: Discussionmentioning

confidence: 80%

Hepatitis B in Pregnant Females. A Cross Sectional Study in Nile Delta, Egypt

Elkadeem

Elnaggar

2021

Preprint

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Background &Aim:Hepatitis B infection is a worldwide health problem. Egypt classified as an area of intermediate endemicity. Hepatitis B has high materno-fetal transmission. The aim of this study was to assess hepatitis B virus infection in Egyptian pregnant females in Nile Delta as regards risk factors and magnitude of the problem.Methods:This cross sectional study was performed on 1948 pregnant females. Historical and sociodemographic data were collected through short simple questionnaire. They were screened for hepatitis B surface antigens. Positive ones were subjected to test hepatitis B e antigen and viral load by real time polymerase chain reaction.Results: Thirty patients (1.54%) were hepatitis B surface antigen positive. Only two of them (6.67%) were hepatitis B e antigen positive with high viral load. Others were hepatitis B e antigen negative and low viral load. Family history of hepatitis B, occupation, age more than 27 years, and history of surgical or dental procedures were significant risk factors associated with hepatitis B acquisition.Conclusion: Screening for hepatitis B is important as a part of antenatal care mainly in the presence of risk factors to follow up mother, and protect fetus so as to prevent wide spread of hepatitis B in Egypt.

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Pattern and interpretation of hepatitis B virus markers among pregnant women in North East Egypt

Cited by 19 publications

References 28 publications

Hepatitis B and C viruses’ infection and associated factors among pregnant women in the Amhara region, Ethiopia: implications for prevention of vertical transmission.

Hepatitis B and C viruses’ infection and associated factors among pregnant women in the Amhara region, Ethiopia: implications for prevention of vertical transmission.

Liver Morbidity in Patients Negative for Overt HBV and HCV Undergoing Maintenance Hemodialysis: a Hospital-based Study

Hepatitis B in Pregnant Females. A Cross Sectional Study in Nile Delta, Egypt

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Pattern and interpretation of hepatitis B virus markers among pregnant women in North East Egypt

Cited by 19 publications

References 28 publications

Hepatitis B and C viruses’ infection and associated factors among pregnant women in the Amhara region, Ethiopia: implications for prevention of vertical transmission.

Hepatitis B and C viruses’ infection and associated factors among pregnant women in the Amhara region, Ethiopia: implications for prevention of vertical transmission.

Liver Morbidity in Patients Negative for Overt HBV&nbsp;and HCV&nbsp;Undergoing Maintenance Hemodialysis: a Hospital-based Study

Hepatitis B in Pregnant Females. A Cross Sectional Study in Nile Delta, Egypt

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Liver Morbidity in Patients Negative for Overt HBV and HCV Undergoing Maintenance Hemodialysis: a Hospital-based Study