Pattern EPs in endocrine orbitopathy

Wijngaarde, R.; Lith, G. H. M. Van

doi:10.1007/bf00141461

Cited by 23 publications

(24 citation statements)

References 5 publications

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“…25 The sug¬ gestion that the mechanism for cen¬ tral scotoma and acuity loss in thyroid eye disease may be ischemie,26 exacer¬ bated by pressure27 rather than de¬ myelinative, is consistent with this finding. Riemslag et al7 have reported delayed pattern reversal VEPs to both tran¬ sient and steady-state stimulation in optic neuritis.…”

supporting

confidence: 52%

Visual Evoked Potentials to Multiple Temporal Frequencies

Bobak

Friedman²,

Brigell³

et al. 1988

Arch Ophthalmol

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supporting

confidence: 52%

Visual Evoked Potentials to Multiple Temporal Frequencies

Bobak

Friedman²,

Brigell³

et al. 1988

Arch Ophthalmol

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“…It is thus imperative to confirm diagnosis early to avoid irreversible visual loss and unnecessary treatments in alternative causes 5 . Ancillary tests, for example optical coherence tomography 6 , orbital imaging 7 and electrophysiological studies (EPS), including visual evoked potential (VEP) and electroretinogram (ERG) were attempts to objectively assess the presence, predict the development and correlate with the severity of DON 8 – 23 . However, methodologies and results were heterogeneous across studies.…”

Section: Introductionmentioning

confidence: 99%

Electrophysiological Studies in Thyroid Associated Orbitopathy: A Systematic Review

Iao

Rong

Ling

et al. 2017

Sci Rep

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Dysthyroid optic neuropathy (DON) is the commonest cause of blindness in thyroid associated orbitopathy (TAO). While diagnosis remains clinical, objective tests for eyes with early or equivocal findings are lacking. Various electrophysiological studies (EPS) have been reported, yet the types and parameters useful for DON remain inconclusive. We performed a systematic literature search in MEDLINE, EMBASE and the Cochrane databases via the OVID platform up to August 20, 2017. 437 records were identified for screening and 16 original studies (1327 eyes, 787 patients) were eligible for review. Pattern visual evoked potential (pVEP) was the most frequently studied EPS. Eyes of TAO patients with DON showed delayed P100 latencies, decreased P100 amplitudes or delayed N75 latencies during pVEP, compared to those without or healthy controls. Due to study heterogeneity, no quantitative analysis was possible. This review highlights the most common type (pVEP) and useful parameters (P100 latency and amplitude) of EPS, and supports further research on them using standardized testing conditions.

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“…Clinically important ON can therefore be missed if not sought specifically (Neigel et al ., 1988). The diagnosis of ON is based on several parameters and its prevalence depends on which diagnostic criteria are chosen and how they are defined (Wijngaarde & van Lith, 1980; Kennerdell et al ., 1981; Trobe, 1981; Neigel et al ., 1988; Batch & Lepre, 1990; Setala et al ., 1992). Compression of the optic nerve by enlarged muscles in the posterior orbit probably accounts for most cases of ON (Trokel & Jakobiec, 1981; Feldon et al ., 1985; Hallin & Feldon, 1988b; Nugent et al ., 1990).…”

mentioning

confidence: 99%

Controversies in the clinical evaluation of active thyroid‐associated orbitopathy: use of a detailed protocol with comparative photographs for objective assessment

Dickinson¹,

Perros²

2001

Clinical Endocrinology

181

105

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SummaryDespite many learned publications over recent decades, the assessment of active thyroid-associated orbitopathy (TAO) remains difficult and controversial. There are no biochemical, immunological or imaging investigations which can identify active disease reliably, and clinical assessment is still of paramount importance. We therefore review the strengths and weaknesses of all methods of clinical assessment. A new atlas for clinical assessment of soft tissue signs has been developed, and its reproducibility assessed. It details a suggested protocol that could help standardize descriptions of TAO and allow more objective assessment of its activity and severity. This is relevant to general endocrinologists, who have a crucial role in the identification of patients who require ophthalmological assessment. Certain aspects are more relevant to ophthalmologists and endocrinologists who have a special clinical and research interest in TAO. Unless a reproducible system of assessment is devised and widely adopted, it will remain difficult to interpret research meaningfully, particularly if results appear to contradict.

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Pattern EPs in endocrine orbitopathy

Cited by 23 publications

References 5 publications

Visual Evoked Potentials to Multiple Temporal Frequencies

Visual Evoked Potentials to Multiple Temporal Frequencies

Electrophysiological Studies in Thyroid Associated Orbitopathy: A Systematic Review

Controversies in the clinical evaluation of active thyroid‐associated orbitopathy: use of a detailed protocol with comparative photographs for objective assessment

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